Immune checkpoint molecules: “new” kids on the block of skin photoimmunology

Emri, 2018, Ultraviolet radiation-mediated development of cutaneous melanoma: an update, J Photochem Photobiol B Biol, 185, 169, 10.1016/j.jphotobiol.2018.06.005 Anna, 2007, Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma, Expert Rev Dermatol, 2, 451, 10.1586/17469872.2.4.451 Kripke, 2013, Reflections on the field of photoimmunology, J Investig Dermatol, 133, 27, 10.1038/jid.2012.234 Halliday, 2012, The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: implications for autoimmunity, J Dermatol Sci, 66, 176, 10.1016/j.jdermsci.2011.12.009 Swann, 2007, Immune surveillance of tumors, J Clin Investig, 117, 1137, 10.1172/JCI31405 Matthews, 2010, A UVB wavelength dependency for local suppression of recall immunity in humans demonstrates a peak at 300 nm, J Investig Dermatol, 130, 1680, 10.1038/jid.2010.27 Matthews, 2010, Wavelength dependency for UVA-induced suppression of recall immunity in humans, J Dermatol Sci, 59, 192, 10.1016/j.jdermsci.2010.07.005 Norval, 2011, The consequences of UV-induced immunosuppression for human health, Photochem Photobiol, 87, 965, 10.1111/j.1751-1097.2011.00969.x Fukunaga, 2010, Langerhans cells serve as immunoregulatory cells by activating NKT cells, J Immunol, 185, 4633, 10.4049/jimmunol.1000246 Toichi, 2008, Skin-infiltrating monocytes/macrophages migrate to draining lymph nodes and produce IL-10 after contact sensitizer exposure to UV-irradiated skin, J Investig Dermatol, 128, 2705, 10.1038/jid.2008.137 Hart, 1998, Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice, J Exp Med, 187, 2045, 10.1084/jem.187.12.2045 Byrne, 2008, Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression, J Immunol, 180, 4648, 10.4049/jimmunol.180.7.4648 Hart, 2011, Modulation of the immune system by UV radiation: more than just the effects of vitamin D?, Nat Rev Immunol, 11, 584, 10.1038/nri3045 Darvin, 2018, Immune checkpoint inhibitors: recent progress and potential biomarkers, Exp Mol Med, 50, 1, 10.1038/s12276-018-0191-1 Boussiotis, 2016, Molecular and biochemical aspects of the PD-1 checkpoint pathway, N Engl J Med, 375, 1767, 10.1056/NEJMra1514296 Zaidi, 2011, Interferon-gamma links ultraviolet radiation to melanomagenesis in mice, Nature, 469, 548, 10.1038/nature09666 Krummel, 1995, CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation, J Exp Med, 182, 459, 10.1084/jem.182.2.459 Syn, 2017, De-novo and acquired resistance to immune checkpoint targeting, Lancet Oncol, 18, e731, 10.1016/S1470-2045(17)30607-1 Mo, 2018, Interferon-gamma signaling in melanocytes and melanoma cells regulates expression of CTLA-4, Cancer Res, 78, 436, 10.1158/0008-5472.CAN-17-1615 Wang, 2019, Upregulation of PD-L1 via HMGB1-activated IRF3 and NF-kappaB contributes to UV radiation-induced immune suppression, Cancer Res, 79, 2909, 10.1158/0008-5472.CAN-18-3134 Oppenheim, 2005, Alarmins: chemotactic activators of immune responses, Curr Opin Immunol, 17, 359, 10.1016/j.coi.2005.06.002 Pomerantz, 1999, NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase, EMBO J, 18, 6694, 10.1093/emboj/18.23.6694 Tojima, 2000, NAK is an IkappaB kinase-activating kinase, Nature, 404, 778, 10.1038/35008109 Bouillez, 2017, MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small-cell lung cancer, Oncogene, 36, 4037, 10.1038/onc.2017.47 Xue, 2017, Type Igamma phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-kappaB, Oncotarget, 8, 42414, 10.18632/oncotarget.17123 Peng, 2015, Chemotherapy induces programmed cell death-ligand 1 overexpression via the nuclear factor-kappaB to foster an immunosuppressive tumor microenvironment in ovarian cancer, Cancer Res, 75, 5034, 10.1158/0008-5472.CAN-14-3098 Wietek, 2003, Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa, J Biol Chem, 278, 50923, 10.1074/jbc.M308135200 Zhu, 2018, Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy, Oncogene, 37, 4941, 10.1038/s41388-018-0314-0 Ullrich, 2012, The immunologic revolution: photoimmunology, J Investig Dermatol, 132, 896, 10.1038/jid.2011.405 Ortner, 2016, Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis, Oncoimmunology, 6, 10.1080/2162402X.2016.1260215 Steerenberg, 1997, Natural killer cell activity during UVR-induced skin tumor formation in the Skh hairless mouse, Photochem Photobiol, 65, 150, 10.1111/j.1751-1097.1997.tb01891.x Barry, 2018, A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments, Nat Med, 24, 1178, 10.1038/s41591-018-0085-8 Bottcher, 2018, NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell, 172, 1022, 10.1016/j.cell.2018.01.004