Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum

Annunziato, 2007, Phenotypic and functional features of human Th17 cells, J. Exp. Med., 204, 1849, 10.1084/jem.20070663 Anthony, 2007, Protective immune mechanisms in helminth infection, Nat. Rev. Immunol., 7, 975, 10.1038/nri2199 Anthony, 2006, Memory Th2 cells induce alternatively activated macrophages to mediate protection against nematode parasites, Nat. Med., 12, 955, 10.1038/nm1451 Artis, 2006, New weapons in the war on worms: identification of putative mechanisms of immune-mediated expulsion of gastrointestinal nematodes, Int. J. Parasitol., 36, 723, 10.1016/j.ijpara.2006.02.011 Artis, 1999, Trichuris muris: host intestinal epithelial cell hyperproliferation during chronic infection is regulated by interferon, Exp. Parasitol., 92, 144, 10.1006/expr.1999.4407 Bailey, 1993, Specific immunological unresponsiveness following active primary responses to proteins in the weaning diet of piglets, Int. Arch. Allergy Immunol., 101, 266, 10.1159/000236456 Barington, 1992, A simplification of the enzyme-linked immunospot technique. Increased sensitivity for cells secreting IgG antibodies to Haemophilus influenza type b capsular polysaccharide, J. Immunol. Methods, 156, 191, 10.1016/0022-1759(92)90025-O Beer, 1973, Studies on the biology of the life-cycle of Trichuris suis Schrank, 1788, Parasitology, 67, 253, 10.1017/S0031182000046497 Beskow, 2003, Outdoor pig production in the Northern part of Sweden. Aspects on health and productivity, Svensk Veterinartidning, 55, 11 Bethony, 2006, Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm, Lancet, 367, 1521, 10.1016/S0140-6736(06)68653-4 Christensen, 1987, Heterologous antagonistic and synergistic interactions between helminths and between helminths and protozoans in concurrent experimental infections of mammalian hosts, Parasitol. Res., 73, 387, 10.1007/BF00538196 Cliffe, 2005, Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion, Science, 308, 1463, 10.1126/science.1108661 Colwell, 1973, Prolongation of egg production of Nippostrongylus brasiliensis in mice concurrently infected with Nematospiroides dubius, J. Parasitol., 59, 216, 10.2307/3278613 Cox, 2001, Concomitant infections, parasites and immune responses, Parasitology, 122, S23, 10.1017/S003118200001698X Crawley, 2003, Control of immunoglobulin isotype production by porcine B-cells cultured with cytokines, Vet. Immunol. Immunopathol., 91, 141, 10.1016/S0165-2427(02)00293-3 De’Broski, 2009, Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection, J. Exp. Med., 206, 2947, 10.1084/jem.20091268 Diaz, 2005, Use of ELISPOT and ELISA to evaluate IFN-γ, IL-10 and IL-4 responses in conventional pigs, Vet. Immunol. Immunopathol., 106, 107, 10.1016/j.vetimm.2005.01.005 Else, 2005, Have gastrointestinal nematodes outwitted the immune system?, Parasite Immunol., 27, 407, 10.1111/j.1365-3024.2005.00788.x Figueiredo, 2010, Infect. Immun., 78, 3160, 10.1128/IAI.01228-09 Finkelman, 1999, The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections, Curr. Opin. Immunol., 11, 420, 10.1016/S0952-7915(99)80070-3 Frontera, 2007, Concurrent infection with Trichinella spiralis and other helminths in pigs, Vet. Parasitol., 146, 50, 10.1016/j.vetpar.2007.02.013 Haugegaard, 2010, Prevalence of nematodes in Danish industrialized sow farms with loose housed sows in dynamic groups, Vet. Parasitol., 168, 156, 10.1016/j.vetpar.2009.10.009 Hill, 1993, Trichuris suis: a zinc metalloprotease from culture fluids of adult parasites, Exp. Parasitol., 77, 170, 10.1006/expr.1993.1074 Jenkins, 1970, A morphological and histochemical study of Trichuris suis (Schrank, 1788) with special reference to the host–parasite relationship, Parasitology, 61, 357, 10.1017/S0031182000041202 Kotlán, 1948, Studies on the life-history and pathological significance of Oesophagostomum spp. of the domestic pig, Acta Vet. Hung., 1, 14 Kringel, 2006, Trichuris suis population dynamics following a primary experimental infection, Vet. Parasitol., 139, 132, 10.1016/j.vetpar.2006.03.002 Kringel, 2007, Trichuris suis excretory/secretory antigen-specific antibodies in serum from single-inoculated pigs, Parasite Immunol., 29, 327, 10.1111/j.1365-3024.2007.00943.x Kringel, 2006, A time course study of immunological responses in Trichuris suis infected pigs demonstrates induction of a local type 2 response associated with worm burden, Int. J. Parasitol., 36, 915, 10.1016/j.ijpara.2006.04.008 Larsen, 1997, Serological assays for the identification of Oesophagostomum dentatum infections in pigs, Res. Vet. Sci., 63, 5, 10.1016/S0034-5288(97)90150-8 Li, 2012, Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis, Infect. Immun., 80, 2150, 10.1128/IAI.00141-12 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method, Methods, 25, 402, 10.1006/meth.2001.1262 Luna, 1968, Luna's stain for eosinophils Maizels, 2004, Helminth parasites – masters of regulation, Immunol. Rev., 201, 89, 10.1111/j.0105-2896.2004.00191.x Maizels, 2003, Immune regulation by helminth parasites: cellular and molecular mechanisms, Nat. Rev. Immunol., 3, 733, 10.1038/nri1183 Miquel, 2005, Host immune reactions and worm kinetics during the expulsion of Ascaris suum in pigs, Parasite Immunol., 27, 79, 10.1111/j.1365-3024.2005.00752.x Morimoto, 2006, Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut, J. Immunol., 176, 491, 10.4049/jimmunol.176.1.491 Nejsum, 2009, Population dynamics of Trichuris suis in trickle-infected pigs, Parasitology, 136, 691, 10.1017/S0031182009005976 Petersen, 2014, Parasite population dynamics in pigs infected with Trichuris suis and Oesophagostomum dentatum, Vet. Parasitol., 199, 73, 10.1016/j.vetpar.2013.09.030 Petkevicius, 2003, The effect of inulin and sugar beet fibre on Oesophagostomum dentatum infection in pigs, Parasitology, 127, 61, 10.1017/S0031182003003251 Pit, 2001, Parasite-specific antibody and cellular immune responses in humans infected with Necator americanus and Oesophagostomum bifurcum, Parasitol. Res., 87, 722, 10.1007/s004360100419 Powers, 1960, Experimental infections of swine with Trichuris suis, Am. J. Vet. Res., March, 262 Roepstorff, 1987, Resistance of Oesophagostomum spp. in pigs to pyrantel citrate, Vet. Parasitol., 24, 229, 10.1016/0304-4017(87)90044-6 Roepstorff, 1996, Experimental Oesophagostomum dentatum infections in the pig: worm populations resulting from trickle infections with three dose levels of larvae, Int. J. Parasitol., 26, 399, 10.1016/0020-7519(96)00006-9 Roepstorff, 1997, Transmission dynamics of helminth parasites of pigs on continuous pasture: Ascaris suum and Trichuris suis, Int. J. Parasitol., 27, 563, 10.1016/S0020-7519(97)00022-2 Steenhard, 2007, Parasite-specific IL-4 responses in Ascaris suum and Trichuris suis-infected pigs evaluated by ELISPOT, Parasite Immunol., 29, 535, 10.1111/j.1365-3024.2007.00975.x Stewart, 2006 Supali, 2010, Polyparasitism and its impact on the immune system, Int. J. Parasitol., 40, 1171, 10.1016/j.ijpara.2010.05.003 Tilney, 2005, Adaptation of a nematode parasite to living within the mammalian epithelium, J. Exp. Zool., 303A, 927, 10.1002/jez.a.214 Urban, 2000, Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism, J. Immunol., 164, 2046, 10.4049/jimmunol.164.4.2046 van Riet, 2007, Chronic helminth infections induce immunomodulation: consequences and mechanisms, Immunobiology, 212, 475, 10.1016/j.imbio.2007.03.009 Wu, 2012, Worm burden-dependent disruption of the porcine colon microbiota by Trichuris suis infection, PLoS One, 7, e35470, 10.1371/journal.pone.0035470 Zhao, 2008, Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages, Gastroenterol, 135, 217, 10.1053/j.gastro.2008.03.077