Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review

1. Jonas WB. Alternative medicine . J Fam Pract. 1997;45(1): 34-37 .

10.1089/acm.1995.1.245

10.1097/00042737-199612000-00018

4. Prittenger J. Herbal treatments find their way into mainstream America . Wisconsin Med J. 1997;96(3): 30-31 .

10.1001/jama.279.19.1548

6. Johnston B. One-third of nation's adults use herbal remedies: market estimated at $3.24 billion . HerbalGram. 1997;40: 552 .

7. Brevoort P. The US botanical market: an overview . HerbalGram. 1996;36: 49-57 .

10.1001/jama.280.18.1569

10.1056/NEJM199301283280406

10.1016/S0277-9536(96)00257-2

10.2165/00002018-199717050-00006

12. Brevoort P. The booming US botanical market: a new overview . HerbalGram. 1998;44: 33-46 .

10.1006/phrs.1997.0132

14. Harrison P. Herbal medicine takes root in Germany . CMAJ. 1998;158(5): 637-639 .

15. Mahady GB, Parrot J, Lee C, Yun GS, Dan A. Botanical dietary supplement use in peri- and postmenopausal women . Meno-pause. 2003;10(1): 65-72 .

16. Bernstein BJ, Grasso T. Prevalence of complementary and alternative medicine use in cancer patients . Oncology (Huntingt). 2001;15(10): 1267-1272 .

17. Wolf H. Can orally applied immunomodulators improve local defense? In: Masahi KN, ed. Immunotherapy of Infections. New York: Marcel Dekker ; 1994:351-355.

10.1016/S0944-7113(96)80020-1

19. Schulz V, Hansel R, Tyler VE. Agents that increase resistance to diseases. In: Rational Phytotherapy. New York: Springer-Verlag ; 1998:269-285.

10.1128/CDLI.1.2.125-133.1994

10.1016/S0031-3955(16)38810-1

10.1177/153473540200100314

10.1002/cncr.11353

24. Buche J. Alternative Cancer Therapies; 2000. Available at:http://seasilver.threadnet.com/Preventorium/thesis.htm

25. Kruzel T. Cancer of the Prostate—A Naturopathic Perspective; N.D. Available at: http://aanp.net/Library/articles.lay/ProstateCancerTK.html

26. Keeshan MD. Cancer: An Overview of Nutritional and Holistic Approaches to Its Treatment; 1997. Available at: http://www.notdoctors.com/cancview.html

27. Pan MJ. Cancer Treatment With Fu Zheng Pei Ben Principle. Fujian, China: Fujian Science and Technology Publishing House ; 1987.

10.1093/ajhp/56.2.121

29. Tarleton A. Echinacea Juice for Immune Stimulation—Assessment of Risks and Benefits. Austin, Tex: American Botanical Council . HerbClip No. 100874; December 17, 1997.

30. Bauer R. Echinacea: biological effects and active principles. In: Lawson LD, Bauer R, eds. Phytomedicines of Europe: Chemistry and Biological Activity. Washington, DC: American Chemical Society ; 1998:140-157.

31. Bauer R, Wagner H. Echinacea: Handbuch fur Arzte, Apotheker und andere Naturwissenschaftler. Stuttgart, Germany: Wissenschaftliche Verlagsgesellschaft ; 1990.

32. Tyler VE. Phytomedicines in Western Europe: their potential impact on herbal medicine in the United States . HerbalGram. 1994;30: 24-31 .

10.1016/0378-8741(91)90122-T

10.1016/S0944-7113(11)80072-3

35. Dorsch W. Clinical application of extracts from Echinacea purpurea or Echinacea pallida. Critical evaluation of controlled clinical studies . Z Arztl Fortbild Jena. 1996;90: 117-122 .

36. Roesler J, Steinmuller C, Kinderlen A, et al. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans . Int J Immunopharmac. 1991;1 (1)3: 27-38 .

10.1016/S0162-3109(96)00125-7

38. Eichler F, Krueger GR. Effects of non-specific immunostimulants (Echinacin, isoprinosine and thymus factors) on the infection and antigen expression in herpesvirus-6 exposed human lymphoid cells . In Vivo. 1994;8: 565-575 .

39. Lersch C, Zeuner M, Bauer A, et al. Stimulation of the immune response in outpatients with hepatocellular carcinomas by low doses of cyclophosphamide (LDCY), Echinacea purpurea extracts (Echinacin) and thymostimulin . Arch Geschwulsforschung. 1990;60: 379-383 .

10.3109/07357909209024793

41. Reuss D. The treatment of primary chronic polyarthritis with Echinacin . Rheumatology. 1996;5: 29-32 .

42. Viehmann P. Erfahrungen mit einer Echinacea-haltigen Hautsalbe . Erfahrungsheilk. 1978;27: 353-358 .

43. Gunning K, Steele P. Echinacea for the prevention of upper respiratory tract infections . J Fam Pract. 1999;48(2): 93 .

44. Bauer VR, Jurcic K, Puhlmann J, Wagner H. Immunologic in vivo and in vitro studies on Echinacea extracts . Arzneimittelforschung. 1988;38: 276-281 .

45. Wildfeuer A, Mayerhofer D. The effects of plant preparations on cellular functions in body defense . Arzneimittelforschung. 1994;44: 361-366 .

46. Couch JF, Giltner LT. An experimental study of Echinacea therapy . J Agric Res. 1920;20: 63-84 .

47. Osowski S, Rostock M, Bartsch HH, Massing U. Pharmaceutical comparability of different therapeutic Echinacea preparations . Forsch Komplementarmed Klass Naurheilkd. 2000;7(6): 294-300 .

48. Rininger JA, Kickner S, Chigurupati P, McLean A, Franck Z. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells . J Leukoc Biol. 2000;68(4): 503-510 .

49. Coeugniet EG, Elek E. Immunomodulation with Viscum album and Echinacea purpurea extracts . Onkologie. 1987;10(suppl 3): 27-33 .

50. Bauer R. Echinacea drugs—effects and active ingredients . Zeitschrift fur Arztliche Fortbildung (Jena). 1996;90(2): 111-115 .

10.1093/jnci/81.9.669

10.1128/IAI.46.3.845-849.1984

10.1016/S0192-0561(97)00061-1

10.1002/(SICI)1098-2825(1996)10:6<441::AID-JCLA22>3.0.CO;2-W

10.1111/j.2042-7158.1987.tb03182.x

10.1016/S0031-6989(88)80848-8

10.1089/107555301300328115

10.1055/s-2002-36339

10.1016/S0165-2478(99)00085-1

10.1081/IPH-100107340

10.1055/s-2002-34397

10.1211/002235702760345464

10.1078/0944-7113-00105

10.1089/acm.1995.1.145

65. Fugh-Berman A. Homeopathy. In: Alternative Medicine: What Works. Tucson, Ariz: Odonian Press ; 1996:126-138.

10.1016/S0140-6736(86)90410-1

10.1016/S0140-6736(97)02293-9

68. Alibeu JP, Jobert J. Aconite in homeopathic relief of post-operative pain and agitation in children . Pediatrie. 1990;45(7-8): 465-466 .

69. Jacobs J, Jimenez LM, Gloyd SS, Gale JL, Crothers D. Treatment of acute childhood diarrhea with homeopathic medicine: a randomized clinical trial in Nicaragua . Pediatrics. 1994;93(5): 719-725 .

70. Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial . Altern Med Rev. 2002;7(2): 138-149 .

10.1097/00002371-200209000-00005

72. Lersch C, Gain T, Lorenz R, Classen M. Chemoimmunotherapy of malignancies of the gastrointestinal tract . Immunitat und Infektion. 1994;22(2): 58-59 .

10.1258/0956462011916947

10.1002/ptr.888

75. Bauer R. Echinacea: biological effects and active principles. In: Lawson LD, Bauer R, eds. Phytomedicines of Europe: Chemistry and Biological Activity. Washington, DC: American Chemical Society ; 1998:140-157.

76. Braunig B, Knick E. Therapeutische Erfahrungen mit Echinacea pallidae bei grippalen Infekten . Naturheilpraxis. 1993;1: 72-75 .

77. Braunig B, Dorn M, Knick E. Echinacea purpurea radix: Zur Starkung der korpereigenen Abwehr bei grippalen Infekten . Zeitsch Phytotherapie. 1992;13: 7-13 .

78. Scaglione F, Lund B. Efficacy in the treatment of the common cold of a preparation containing echinacea extract . Int J Immunother. 1995;11: 163-166 .

79. Schoneberger D. Influence of the immunostimulating effects of the pressed juice on the duration of density of the common cold. Results of a double-blind clinical trial . Forum Immunologie. 1992;2: 18-22 .

80. Hoheisel O, Sandberg M, Bertram S, Bulitta M, Schafer M. Echinagard treatment shortens the course of the common cold: a double-blind placebo-controlled clinical trial . Eur J Clin Res. 1997;9: 261-268 .

10.1016/S0944-7113(99)80027-0

82. Vorberg G, Schneider B. Pflanzliches Immunstimulans verkurzt grippalen Infeckt. Doppelblindstudie belegt die Steigerung der unspezifischen Infektabwehr . Arztliche Forsch. 1989;36: 3-8 .

83. Dorn M. Milerung grippaler Effeckt durch ein pflanzliches Immunstimulans . Nutur Ganzheitsmedizin. 1989;2: 314-319 .

10.1089/10755530050120691

10.1185/03007999909114094

86. Schulten B, Bulitta M, Ballering-Bruhl B, Koster U, Schafer M Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomized, double-blind clinical trial . Arzneimittelforschung. 2001;51(7): 563-568 .

87. Vorberg G. Bei Erkaltung unspezifische Immunabwehr stimulieran: Doppelblindstudie zeigt: Das bewahrte Phytotherapeutikum. Esberitox verkurzt die Symptommatik . Arztliche Praxis. 1984;36: 97-98 .

88. Reitz HD. Immunmodulatoren mit pflanzlichen Wirkstoffen: eine wissenschafliche Studie am Beispiel Esberitox N . Notabene Med. 1990;20: 362-366 .

89. Galea S, Thacker K. Double-blind prospective trial investigating the effectiveness of a commonly prescribed herbal remedy in altering the duration, severity and symptoms of the common cold. Unpublished manuscript, 1996.

10.7326/0003-4819-137-12-200212170-00006

91. Forth H, Beuscher N. Beeinflussing der Hafigkeit banaler Erkaltungsinfekte furch Esberitox . Zeitsch Allgemeinmedizin. 1981;57: 2272-2275 .

92. Schmidt U, Albrech TM, Schenk N. Pflankliches Immunstimulans senket Haufigkeit grippaler Infekte: Plazebokontrollierte Doppel blindstudie mit einem kombineierten Echinacea-Praparat mit 646 Studenten der Kolner Universitat . Natur Ganzheitsmedizin. 1990;3: 277-281 .

10.1016/S0002-9343(98)00406-9

10.1001/archfami.7.6.541

95. Schoneberger D. Einflub der immunstimulierenden Wirkung von Prebsaft aus Herba echinacea purpurea auf Verlauf und Schweregrad von Erkaltungskrankheiten. Ergebnisse einer Doppelblindstudie . Forum Immunologie. 1992;2: 18-22 .

10.1128/AAC.44.6.1708-1709.2000

10.1592/phco.20.7.690.35173

98. Ness AR, Khaw KT, Bingham S, Day NE. Vitamin C status and respiratory function . Eur J Clin Nutr. 1996;50(9): 573-579 .

10.1139/y98-038

100. Schmidt K. Interaction of antioxidative micronutrients with host defense mechanisms. A critical review . Int J Vitamin Nutr Res. 1997;67(5): 307-311 .

10.1079/PNS19990012

10.1093/ageing/20.3.169

103. Delafuente JC, Prendergast JM, Modigh A. Immunologic modulation by vitamin C in the elderly . Int J Immunopharmacol. 1986;8(2): 205-211 .

10.1016/S0272-2712(18)30723-6

10.1055/s-2007-972864

106. Peters-Futre EM. Vitamin C, neutrophil function, and upper respiratory tract infection risk in distance runners: the missing link . Exercise Immunol Rev. 1997; 3: 32-52 .

107. Grimble RF. Effect of antioxidative vitamins on immune function with clinical applications . Int J Vitamin Nutr Res. 1997;67(5): 312-320 .

10.1093/ajcn/63.6.994

10.1093/ajcn/66.2.464S

10.1093/ajcn/66.2.459S

10.1093/ajcn/66.2.459S

111. Barrett B, Locken K, Maberry R, et al. The Wisconsin Upper Respiratory Symptom Survey (WURSS): a new research instrument for assessing the common cold . J Fam Pract. 2002;51(3): 265 .

10.1078/094471103321648692

113. Barrett B. Echinacea: a safety review . HerbalGram. 2003;57: 36-39 .

10.1016/S1081-1206(10)63591-0

10.1021/tx025559m

10.1001/archinte.163.6.699

10.2165/00003495-200161150-00002

10.1016/0378-8741(92)90057-X

119. Wilkie A, Cordess C. Ginseng—a root just like a carrot? J R Soc Med. 1994;87(10): 594-595 .

10.1007/BF01221390

10.1016/S0140-6736(94)91322-6

122. Anonymous. Herbal roulette . Consumer Reports. 1995; 60(11): 698-705 .

10.1016/S0140-6736(94)92007-9

124. Hall T, Lu, ZZ, Yat PN, et al. Evaluation of consistency of standardized Asian ginseng products in the Ginseng Evaluation Program . HerbalGram. 2001;52: 31-45 .

125. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin, Heidelberg: Springer-Verlag ; 1992:711-737.

126. Sticher O. Biochemical, pharmaceutical and medical perspectives on ginseng. In: Lawson LD, Bauer R, eds. Phytomedicines of Europe: Chemistry and Biological Activity. Oxford University Press: American Chemical Society ; 1998:221-240.

10.1016/0891-5849(95)02020-9

128. Hansson M, Asea A, Ersson U, Hermodsson S, Hellstrand K. Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites . J Immunol. 1996;156(1): 42-47 .

129. Brune M, Hansson M, Mellqvist UH, Hermodsson S, Hellstrand K. NK cell-mediated killing of AML blasts: role of histamine, monocytes and reactive oxygen metabolites . Eur J Haematol. 1996;57(4): 312-319 .

10.1002/eji.1830260620

10.1093/jn/126.suppl_10.2611S

10.1093/jn/120.9.1096

133. Anderson R, van Antwerpen VL. Vitamins in the maintenance of optimum immune functions and in the prevention of phagocyte-mediated tissue damage and carcinogenesis . Bibliotheca Nutr Diet. 1995;52: 66-74 .

134. Krinsky N. Effects of carotenoids in cellular and animal systems . Am J Clin Nutr. 1991;53: 2385-2465 .

135. Lee YS, Chung IS, Lee IR, Kim KH, Hong WS, Yun YS. Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng . Anticancer Res. 1997; 17(1A): 323-331 .

10.3109/08923979609007111

137. Luo YM, Cheng XJ, Yuan WX. Effects of ginseng root saponins and ginsenoside Rb1 on immunity in cold water swim stress mice and rats . Acta Pharmacol Sin. 1993;14(5): 401-404 .

10.3109/08923979009019672

10.1007/BF01972376

10.1142/S0192415X82000087

10.1159/000233470

10.1016/S0009-8981(02)00343-1

143. Gupta S, Agarwal SS, Epstein LB, Fernandez G, Good RA. Panax ginseng: a new mitogen and interferon inducer . Clin Res. 1980;504A: 28-32 .

144. Ha TU, Lee JH, Kim SH. Effect of Panax ginseng on the graft-versus-host reaction, production of leukocyte migration inhibitory factor and expulsion of adult Trichinella spiralis in mice . J Kor Soc Microbiol. 1986;21: 132-144 .

10.1111/j.1699-0463.1997.tb00591.x

10.1128/CDLI.5.6.882-887.1998

10.1089/107555302760253658

10.1016/S0165-2427(02)00264-7

10.1016/S0165-2427(02)00269-6

10.1016/S0264-410X(02)00518-2

10.1046/j.1439-0450.2001.00470.x

152. Yun YS, Moon HS, Oh YR, Jo SK, Kim YJ, Yun TK. Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene . Cancer Detect Prev. 1987;1(suppl): 301-309 .

10.1007/BF01972376

10.1006/bbrc.1994.1644

155. Liu M, Zhang JT. Studies on the mechanisms of immunoregulatory effects of ginsenoside Rg1 in aged rats . Acta Pharmacol Sin. 1996;31(2): 95-100 .

156. Liu M, Zhang JT. Immunoregulatory effects of ginsenoside Rg1 in aged rats . Acta Pharmacol Sin. 1995;30(11): 818-823 .

157. Niu YP, Jin JM, Gao RL, Xie GL, Chen XH. Effects of ginsenosides Rg1 and Rb1 on proliferation of human marrow granulocyte-macrophage progenitor cells . Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2001;9(2): 178-180 .

10.1007/s002280050674

10.2165/00007256-200029020-00004

10.1016/0047-6374(95)01618-A

10.1093/ajcn/70.4.536

10.1016/0306-9877(92)90191-E

163. Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F. Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer . Drugs Exper Clin Res. 1990; 16(10): 537-542 .

164. Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardized Ginseng extract G115 of potentiating vaccination against the influenza syndrome and protection against the common cold . Drugs Exper Clin Res. 1996;22(2): 65-72 .

165. Stevenson H, Tsang KY. Tumor immunology. In: Virella G, ed. Introduction to Medical Immunology. 3rd ed. New York: Marcel Dekker ; 1993:497-515.

166. Kopreski MS. Interactions between chemotherapeutic drugs and biologic agents. In: Chabner BA, Long DL, eds. Cancer Chemotherapy and Biotherapy. 2nd ed. Philadelphia: Lippincott-Raven ; 1996:765-785.

10.1016/S0378-8741(97)00133-5

168. Lin SY, Liu LM, Wu LC. Effects of Shenmai injection on immune function in cancer patients after chemotherapy . Chung-Kuo Chung Hsi i Chieh Ho Tsa Chih. 1995;15(8): 451-453 .

169. Zee-Cheng RK. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs . Methods Find Exp Clin Pharmacol. 1992; 14(9): 725-736 .

170. Shen RN, Lu L, Jia XQ, Wong ML, Kaiser HE. Naturin: a potent bio-immunomodifier in experimental studies and clinical trials . In Vivo. 1996;10(2): 201-209 .

171. Xie FY, Zeng ZF, Huang HY. Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radio-therapy and ginseng polysaccharide injection . Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(5): 332-334 .

172. Suh SO, Kroh M, Kim NR, Joh YG, Cho MY. Effects of red ginseng upon postoperative immunity and survival in patients with Stage III gastric cancer . Am J Chin Med. 2002;30(4): 482-494 .

10.1211/0022357011777882

174. Vereshchagen IA. Treatment of dysentery in children with combination of monomycin and eleutherococcus . Antibiotiki (Moscow). 1978;23: 633 .

175. Bohn B, Nebe CT, Birr C. Flow-cytometric studies with eleutherococcus senticosus extract as an immunomodulatory agent . Arzneimittelforschung. 1987;37(10): 1193-1196 .

10.1177/1534735403251167

177. Beinfeield H, Korngold E. The cauldron of Chinese herbs. In: Between Heaven and Earth. New York: Ballantine ; 1991:265-321.

178. Bensky D, Gamble A. Chinese Herbal Medicine: Materia Medica. Rev ed. Seattle, Wash: Eastland Press ; 1993.

179. Yu RC, Guan CF, Zhang JH. Immune function of cancer patients with spleen-deficiency syndrome . Chin J Modern Dev Tradit Med. 1990;10(9): 535-537, 516 .

180. Sun Y, Hersh EM, Lee SL, McLaughlin M, Loo TL, Mavligit GM. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses . J Biol Response Mod. 1983;2(3): 227-237 .

181. Li XY. Immunomodulating Chinese herbal medicines . Memorias do Instituto Oswaldo Cruz. 1991;86 (suppl 2): 159-164 .

182. Miller AL. Botanical influences on cardiovascular disease . Alt Med Rev. 1998;3(6): 422-431 .

183. Sun Y, Hong WJ, Deng J. 10-year follow-up study of cancer patients with fu-zheng therapy . Chin J Modern Dev Tradit Med. 1987;7(12): 712-714, 707 .

184. Zhang XQ, Liu SJ, Pan XY. Clinical study on treatment of chemo- or radiotherapy induced leukopenia with fu-zheng compound . Chung-Kuo Chung Hsi i Chieh Ho Tsa Chih. 1996;16(1): 27-28 .

185. Hong YH. Oriental Materia Medica: A Concise Guide. Long Beach, Calif: Oriental Healing Arts Institute ; 1986.

186. Wang D, Shen W, Tian Y, Sun Z, Jiang C, Yuan S. Protective effect of active components extracted from radix Astragali on human erythrocyte membrane damages caused by reactive oxygen species . China J Chin Mat Med. 1996;21(12): 746-748, 763 .

10.1016/S0192-0561(97)00076-3

188. Peng T, Riesemann H, Kandolf R. The inhibitory effect of Astragalus membranaceus on coxsackie B3 virus RNA replication . Chin Med Sci J. 1995;10: 146-150 .

189. Yuan WL, Chen HZ, Yang YZ, et al. Effect of astragalus membranaceus on electric activities of cultured rat beating heart cells infected with Coxsackie B-2 virus . Chin Med J. 1990;103(3): 177-182 .

190. Guo Q, Peng TQ, Yang YZ. Effect of Astragalus membranaceus on Ca 2+ influx and coxsackie virus B3 replication in cultured neonatal rat heart cells . Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995;15: 483-485 .

191. Wang RT, Shan BE, Li QX. Extracorporeal experimental study on immuno-modulatory activity of Astragalus memhranaceus extract . Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(6): 453-456 .

192. Wang Y, Qian XJ, Hadley HR, Lau BH. Phytochemicals potentiate interleukin-2 generated lymphokine-activated killer cell cytotoxicity against murine renal cell carcinoma . Mol Biother. 1992;4: 143-146 .

193. Chu DT, Lin JR, Wong W. The in vitro potentiation of LAK cell cytotoxicity in cancer and AIDS patients induced by F3-a fractionated extract of Astragalus membranaceus . Chung Hua Chung Liu Tsa Chih. 1994;16: 167-171 .

194. Chu DT, Lepe-Zuniga J, Wong WL, LaPushin R, Mavligit GM. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2 . J Clin Lab Immunol. 1988;26(4): 183-187 .

10.1089/cbr.1994.9.153

10.1016/S0022-5347(17)37830-8

197. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs: II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo . J Clin Lab Immunol. 1988;25(3): 125-129 .

10.1016/0162-3109(90)90038-G

199. Jin R, Wan LL, Mitsuishi T. Effects of shi-ka-ron and Chinese herbs in mice treated with anti-tumor agent mitomycin C . Chung-Kuo Chung Hsi i Chieh Ho Tsa Chih. 1995;15(2): 101-103 .

200. Khoo KS, Ang PT. Extract of Astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression . Singapore Med J. 1995;36(4): 387-390 .

201. Zhao KW, Kong HY. Effect of Astragalan on secretion of tumor necrosis factor in human peripheral mononuclear cells . Chung Kuo Hsi I Chieh Ho Tsa Chih. 1993;13: 263-265 .

10.1002/1097-0142(19830701)52:1<70::AID-CNCR2820520114>3.0.CO;2-S

203. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs: I. Immune restoration of local xenogeneic graft-versus-host reaction in cancer patients by fractionated Astragalus membranaceus in vitro . J Clin Lab Immunol. 1988;25(3): 119-123 .

204. Hou YD, Ma GL, Wu SH, Li YY, Li HT. Effect of Radix Astragali seu Hedysari on the interferon system . Chin Med J. 1981; 94(1): 35-40 .

205. Anonymous. Immunity parameters and blood CAMP changes in normal persons after ingestion of radix astragali . Natl Med J China. 1979;59: 31-34 .

206. Cha RJ, Zeng DW, Chang QS. Non-surgical treatment of small cell lung cancer with chemo-radio-immunotherapy and traditional Chinese medicine . Chung Hua Nei Ko Tsa Chih. 1994;33: 462-466 .

207. Duan P, Wang ZM. Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor . Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(7): 515-517 .

208. Li NQ. Clinical and experimental study on shen-qi injection with chemotherapy in the treatment of malignant tumor of digestive tract . Zhonggou Zhong Xi Yi Jie Ha Za Zhi. 1992; 12(10): 588-592 .

209. Huang ZQ, Qin NP, Ye W. Effect of Astragalus membranaceus on T-lymphocyte subsets in patients with viral myocarditis . Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995;15: 328-330 .

210. Yang YZ, Jin PY, Guo Q, et al. Effect of Astragalus membranaceus on natural killer cell activity and induction of alpha- and gamma- interferon in patients with coxsackie B viral myocarditis . Chung-Hua I Hsheh Tsa Chih. (English ed) 1990; 103(4): 304-307 .

211. Zhao XZ. Effects of Astragalus membranaceus and Tripterygium hypoglanucum on natural killer cell activity of peripheral blood mononuclear cells in systemic lupus erythematous . Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1992;12: 679-671 .

212. Woo WS, Lee EB, Change I. Biological evaluation of Korean medicinal plants: II . Yakhak Hoe Chi. 1977;21: 177-183 .

213. Lim DY. A study on the hypotensive action of Astragali Radix water extract in the rabbit . Yakhak Hoe Chi. 23: 69-80 .

214. Li Y, Liu XJ, Zhao LB, Xue SZ. Study on the antidotal effect against intoxication of dimethoate with extract from Astragalus membranaceus in guinea pig . Gongye Weisheng Yu Zhiyebing. 1994; 20: 331-334 .

215. Yuan WL, Chen HZ, Yang YZ, Yang XY, Lin YS, Jin PY. Effect of Astragalus membranaceus on electric activities of cultured rat beating heart cells infected with Coxsackie B-2 virus . Chung-Hua Hsueh Tsa Chih. (English ed) 1990;103: 177-182 .

216. Zhou JY, Fan Y, Kong JL, Wu DZ, Hu ZB. Effects of components isolated from Astragalus membranaceus on cardiac function injured by myocardial ischemia reperfusion in rats . Zhongguo Zhongyao Zazhi. 2000;25: 300-302 .

217. Song MJ, Kim H. Inhibitory effect of herbal medicines on rota-virus infection . Korean J Pharmacognosy. 1998;29: 125-128 .

218. Beinfeield H, Korngold E. Philosophy in the East: the doctor as gardener. In: Between Heaven and Earth. New York: Ballantine ; 1991:29-47.

10.1093/ajcn/66.6.1303

10.1016/0192-0561(94)90059-0

10.1021/jf0014157

222. Herberman RB. Multiple functions of natural killer cells, including immunoregulation as well as resistance to tumor growth . Concepts Immunopathol. 1985;1: 96-132 .

10.1006/meth.1996.0044

10.1007/BF00049480

10.1016/S0301-472X(01)00696-8

226. Rosenberg AS, Brown AE. Infection in the cancer patient . Disease-A-Month. 1993;39(7): 505-569 .

10.1177/030006059001800302

10.1067/mtc.2001.113026

10.1002/(SICI)1097-0142(19970201)79:3<474::AID-CNCR8>3.0.CO;2-I

10.1007/BF00682700

10.1016/S0022-5347(17)39854-3

10.1111/j.1572-0241.2001.03535.x

10.1089/cbr.1996.11.355

234. Orsi AJ, Tax AW, Nuamah I, Barsevick A, McCorkle R. Natural killer cells over time in patients with colorectal cancer . Cancer Pract. 1996;4(5): 252-257 .

10.1016/0960-7404(94)90036-1

10.1016/0192-0561(86)90010-X

10.1097/00000542-199509000-00008

10.1159/000054906

10.1016/0041-008X(87)90079-2

10.1006/enrs.1999.3968

10.1007/BF02884961

10.1200/JCO.1987.5.3.348

10.1080/08964289.1991.9935161