Immune Aging and Rheumatoid Arthritis

Rheumatic Disease Clinics of North America - Tập 36 Số 2 - Trang 297-310 - 2010
Jörg J. Goronzy1, Lan Shao1, Cornelia M. Weyand1
1Division of Immunology and Rheumatology, Department of Medicine, Stanford University, 269 West Campus Drive, Stanford, CA 94305-5166, USA

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Kokkonen, 2010, Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis, Arthritis Rheum, 62, 383

Weyand, 1997, Pathogenesis of rheumatoid arthritis, Med Clin North Am, 81, 29, 10.1016/S0025-7125(05)70504-6

Goronzy, 2009, Developments in the scientific understanding of rheumatoid arthritis, Arthritis Res Ther, 11, 249, 10.1186/ar2758

Doran, 2002, Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period, Arthritis Rheum, 46, 625, 10.1002/art.509

Goronzy, 2005, Rheumatoid arthritis, Immunol Rev, 204, 55, 10.1111/j.0105-2896.2005.00245.x

Larbi, 2008, Immune receptor signaling, aging and autoimmunity, Adv Exp Med Biol, 640, 312, 10.1007/978-0-387-09789-3_21

Weyand, 2003, Giant-cell arteritis and polymyalgia rheumatica, Ann Intern Med, 139, 505

Weyand, 2003, Medium- and large-vessel vasculitis, N Engl J Med, 349, 160, 10.1056/NEJMra022694

Moulias, 1984, Age-related increase in autoantibodies, Lancet, 1, 1128, 10.1016/S0140-6736(84)92547-9

Grubeck-Loebenstein, 2002, The aging of the immune system, Adv Immunol, 80, 243, 10.1016/S0065-2776(02)80017-7

Weng, 2006, Aging of the immune system: how much can the adaptive immune system adapt?, Immunity, 24, 495, 10.1016/j.immuni.2006.05.001

Targonski, 2007, Immunosenescence: role and measurement in influenza vaccine response among the elderly, Vaccine, 25, 3066, 10.1016/j.vaccine.2007.01.025

Jefferson, 2005, Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review, Lancet, 366, 1165, 10.1016/S0140-6736(05)67339-4

Nichol, 2007, Effectiveness of influenza vaccine in the community-dwelling elderly, N Engl J Med, 357, 1373, 10.1056/NEJMoa070844

Donahue, 1995, The incidence of herpes zoster, Arch Intern Med, 155, 1605, 10.1001/archinte.155.15.1605

Arvin, 2005, Aging, immunity, and the varicella-zoster virus, N Engl J Med, 352, 2266, 10.1056/NEJMp058091

Thompson, 2003, Mortality associated with influenza and respiratory syncytial virus in the United States, JAMA, 289, 179, 10.1001/jama.289.2.179

Looney, 2001, Hepatitis B immunization of healthy elderly adults: relationship between naive CD4 + T-cells and primary immune response and evaluation of GM-CSF as an adjuvant, J Clin Immunol, 21, 30, 10.1023/A:1006736931381

Goronzy, 2005, T-cell development and receptor diversity during aging, Curr Opin Immunol, 17, 468, 10.1016/j.coi.2005.07.020

Naylor, 2005, The influence of age on T-cell generation and TCR diversity, J Immunol, 174, 7446, 10.4049/jimmunol.174.11.7446

Gomez, 2005, The aging innate immune system, Curr Opin Immunol, 17, 457, 10.1016/j.coi.2005.07.013

Niessner, 2010, Dendritic cells in atherosclerotic disease, Clin Immunol, 134, 25, 10.1016/j.clim.2009.05.006

Weyand, 2008, T-cells in arteritis and atherosclerosis, Curr Opin Lipidol, 19, 469, 10.1097/MOL.0b013e32830bfdc2

Hakim, 2005, Age-dependent incidence, time course, and consequences of thymic renewal in adults, J Clin Invest, 115, 930, 10.1172/JCI200522492

Czesnikiewicz-Guzik, 2008, T-cell subset-specific susceptibility to aging, Clin Immunol, 127, 107, 10.1016/j.clim.2007.12.002

Nikolich-Zugich, 2008, Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections, Nat Rev Immunol, 8, 512, 10.1038/nri2318

Hodes, 2002, Telomeres in T- and B-cells, Nat Rev Immunol, 2, 699, 10.1038/nri890

Jendro, 1995, Emergence of oligoclonal T-cell populations following therapeutic T-cell depletion in rheumatoid arthritis, Arthritis Rheum, 38, 1242, 10.1002/art.1780380912

Brett, 1996, Repopulation of blood lymphocyte sub-populations in rheumatoid arthritis patients treated with the depleting humanized monoclonal antibody, CAMPATH-1H, Immunology, 88, 13, 10.1046/j.1365-2567.1996.d01-650.x

Lorenzi, 2008, Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes, Arthritis Rheum, 58, 370, 10.1002/art.23122

Jones, 2009, IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H), J Clin Invest, 119, 2052

Koetz, 2000, T-cell homeostasis in patients with rheumatoid arthritis, Proc Natl Acad Sci U S A, 97, 9203, 10.1073/pnas.97.16.9203

Kong, 1999, T-cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T-cell pool, Proc Natl Acad Sci U S A, 96, 1536, 10.1073/pnas.96.4.1536

Douek, 1998, Changes in thymic function with age and during the treatment of HIV infection, Nature, 396, 690, 10.1038/25374

van den Dool, 2006, The effects of age, thymectomy, and HIV Infection on alpha and beta TCR excision circles in naive T-cells, J Immunol, 177, 4391, 10.4049/jimmunol.177.7.4391

Ponchel, 2002, Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis, Blood, 100, 4550, 10.1182/blood-2002-03-0671

Hazenberg, 2000, Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T-cell population in HIV-1 infection, Nat Med, 6, 1036, 10.1038/79549

Hazenberg, 2003, Thymic output: a bad TREC record, Nat Immunol, 4, 97, 10.1038/ni0203-97

Andrews, 2009, Telomeres and immunological diseases of aging, Gerontology

Vallejo, 1998, Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene specific nuclear factor binding activity, J Biol Chem, 273, 8119, 10.1074/jbc.273.14.8119

Effros, 2005, The role of CD8 + T-cell replicative senescence in human aging, Immunol Rev, 205, 147, 10.1111/j.0105-2896.2005.00259.x

Schmidt, 1996, CD4 + CD7-CD28-T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity, J Clin Invest, 97, 2027, 10.1172/JCI118638

Schmidt, 1996, The repertoire of CD4 + CD28-T cells in rheumatoid arthritis, Mol Med, 2, 608, 10.1007/BF03401644

Wagner, 1998, Perturbation of the T-cell repertoire in rheumatoid arthritis, Proc Natl Acad Sci U S A, 95, 14447, 10.1073/pnas.95.24.14447

Thewissen, 2007, Analyses of immunosenescent markers in patients with autoimmune disease, Clin Immunol, 123, 209, 10.1016/j.clim.2007.01.005

Schönland, 2003, Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages, Proc Natl Acad Sci U S A, 100, 13471, 10.1073/pnas.2233561100

Shao, 2009, Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis, J Exp Med, 206, 1435, 10.1084/jem.20082251

Goronzy, 2004, Prognostic markers of radiographic progression in early rheumatoid arthritis, Arthritis Rheum, 50, 43, 10.1002/art.11445

Martens, 1997, Expansion of unusual CD4 + T-cells in severe rheumatoid arthritis, Arthritis Rheum, 40, 1106, 10.1002/art.1780400615

Bryl, 2001, Down-regulation of CD28 expression by TNF-alpha, J Immunol, 167, 3231, 10.4049/jimmunol.167.6.3231

Bryl, 2005, Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis, Arthritis Rheum, 52, 2996, 10.1002/art.21353

Warrington, 2003, CD28 loss in senescent CD4 + T-cells: reversal by interleukin-12 stimulation, Blood, 101, 3543, 10.1182/blood-2002-08-2574

Chapman, 1996, CD11b+CD28-CD4+ human T-cells: activation requirements and association with HLA-DR alleles, J Immunol, 157, 4771, 10.4049/jimmunol.157.11.4771

Waase, 1996, Oligoclonal T-cell proliferation in patients with rheumatoid arthritis and their unaffected siblings, Arthritis Rheum, 39, 904, 10.1002/art.1780390606

van Leeuwen, 2004, Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T-cell subset after recovery of primary cytomegalovirus infection, J Immunol, 173, 1834, 10.4049/jimmunol.173.3.1834

Palm, 2008, How shelterin protects mammalian telomeres, Annu Rev Genet, 42, 301, 10.1146/annurev.genet.41.110306.130350

Weyand, 2009, Rejuvenating the immune system in rheumatoid arthritis, Nat Rev Rheumatol, 5, 583, 10.1038/nrrheum.2009.180

Fujii, 2009, Telomerase insufficiency in rheumatoid arthritis, Proc Natl Acad Sci U S A, 106, 4360, 10.1073/pnas.0811332106

Colmegna, 2008, Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis, Arthritis Rheum, 58, 990, 10.1002/art.23287

Lavin, 2005, Atm and cellular response to DNA damage, Adv Exp Med Biol, 570, 457, 10.1007/1-4020-3764-3_16

King, 2004, Homeostatic expansion of T-cells during immune insufficiency generates autoimmunity, Cell, 117, 265, 10.1016/S0092-8674(04)00335-6

Crisa, 1992, Autoimmune diabetes mellitus in the BB rat, Diabetes Metab Rev, 8, 4, 10.1002/dmr.5610080104

Glant, 2003, Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics, Crit Rev Immunol, 23, 199, 10.1615/CritRevImmunol.v23.i3.20

Goronzy, 2003, Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity—catalysts of autoimmunity and chronic inflammation, Arthritis Res Ther, 5, 225, 10.1186/ar974

Goronzy, 2001, Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis, Trends Immunol, 22, 251, 10.1016/S1471-4906(00)01841-X

Cope, 2008, T-cells in rheumatoid arthritis, Arthritis Res Ther, 10, S1, 10.1186/ar2412

Singh, 2008, Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis, J Immunol, 180, 1971, 10.4049/jimmunol.180.3.1971

Sawai, 2005, T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis, Arthritis Rheum, 52, 1392, 10.1002/art.21140

Davila, 2005, Cell-based immunotherapy with suppressor CD8 + T-cells in rheumatoid arthritis, J Immunol, 174, 7292, 10.4049/jimmunol.174.11.7292

Sawai, 2007, Fractalkine mediates T-cell dependent proliferation of synovial fibroblasts in rheumatoid arthritis, Arthritis Rheum, 56, 3215, 10.1002/art.22919

Goronzy, 2005, Costimulatory pathways in rheumatoid synovitis and T-cell senescence, Ann N Y Acad Sci, 1062, 182, 10.1196/annals.1358.022

Singh, 2009, ERK-dependent T-cell receptor threshold calibration in rheumatoid arthritis, J Immunol, 183, 8258, 10.4049/jimmunol.0901784

Warrington, 2005, Rheumatoid arthritis is an independent risk factor for multivessel coronary artery disease: a case control study, Arthritis Res Ther, 7, R984, 10.1186/ar1775

Crowson, 2010, Could accelerated aging explain the excess mortality in patients with seropositive rheumatoid arthritis?, Arthritis Rheum, 62, 378

Liuzzo, 1999, Perturbation of the T-cell repertoire in patients with unstable angina, Circulation, 100, 2135, 10.1161/01.CIR.100.21.2135

Liuzzo, 2001, Molecular fingerprint of interferon-gamma signaling in unstable angina, Circulation, 103, 1509, 10.1161/01.CIR.103.11.1509

Nakajima, 2002, T-cell mediated lysis of endothelial cells in acute coronary syndromes, Circulation, 105, 570, 10.1161/hc0502.103348

Niessner, 2006, Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha, Circulation, 114, 2482, 10.1161/CIRCULATIONAHA.106.642801

Sato, 2006, TRAIL-expressing T-cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque, J Exp Med, 203, 239, 10.1084/jem.20051062

Pryshchep, 2006, T-cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome, Circ Res, 98, 1168, 10.1161/01.RES.0000220649.10013.5c

Liuzzo, 2000, Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes, Circulation, 101, 2883, 10.1161/01.CIR.101.25.2883

Pryshchep, 2010, Insufficient deactivation of the protein tyrosine kinase Lck amplifies T-cell responsiveness in acute coronary syndrome, Circ Res, 106, 769, 10.1161/CIRCRESAHA.109.206052

Pasceri, 1999, A tale of two diseases: atherosclerosis and rheumatoid arthritis, Circulation, 100, 2124, 10.1161/01.CIR.100.21.2124