Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats

Yohei Hamaue1,2, Jiro Nakano3, Yuki Sekino1, Sayaka Chuganji3, J. Sakamoto4, Tsuyoshi Yoshimura1, Tomoki Origuchi1, Minoru Okita1
1Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
2Department of Rehabilitation, Juzenkai Hospital, Nagasaki, Japan
3Unit of Physical and Occupational Therapy Sciences, Nagasaki University Graduate School of Biochemical Sciences, Nagasaki, Japan
4Department of Rehabilitation, Nagasaki University Hospital, Nagasaki, Japan

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Okita M, Yoshimura T, Nakano J, Motomura M, Eguchi K (2004) Effects of reduced joint mobility on sarcomere length, collagen fibril arrangement in the endomysium, and hyaluronan in rat soleus muscle. J Muscle Res Cell Motil 25:159–166

Terkelsen AJ, Bach FW, Jensen TS (2008) Experimental forearm immobilization in humans induces cold and mechanical hyperalgesia. Anesthesiology 109:297–307

Ushida T, Willis WD (2001) Changes in dorsal horn neuronal responses in an experimental wrist contracture model. J Orthop Sci 6:46–52

Nishigami T, Osako Y, Tanaka K, Yuri K, Kawasaki M, Ikemoto T, McLaughlin M, Ishida K, Tani T, Ushida T (2009) Changes in calcitonin gene-related peptide expression following joint immobilization in rats. Neurosci Lett 454:97–100

Neumann S, Doubell TP, Leslie T, Woolf CJ (1996) Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature 384:360–364

Nitzan-Luques A, Devor M, Tal M (2011) Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain. Pain 152:2413–2426

Bennett AD, Chastain KM, Hulsebosch CE (2000) Alleviation of mechanical and thermal allodynia by CGRP (8–37) in a rodent model of chronic central pain. Pain 86:163–175

Sun RQ, Lawand NB, Willis WD (2003) The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin. Pain 104:201–208

Sun RQ, Tu YJ, Lawand NB, Yan JY, Lin Q, Willis WD (2004) Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization. J Neurophysiol 92:2859–2866

Kangrga I, Randic M (1990) Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice. J Neurosci 10:2026–2038

Ohmichi Y, Sato J, Ohmichi M, Sakurai H, Yoshimoto T, Morimoto A, Hashimoto T, Eguchi K, Nishihara M, Arai YC, Ohishi H, Asamoto K, Ushida T, Nakano T, Kumazawa T (2011) Two-week cast immobilization induced chronic widespread hyperalgesia in rats. Eur J Pain 16:338–348

Coderre TJ, Katz J, Vaccarino AL, Melzack R (1993) Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52:259–285

Nakano J, Sekino Y, Hamaue Y, Sakamoto J, Yoshimura T, Origuchi T, Okita M (2012) Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats. Physiol Res 61:643–647

Koganezawa T, Ishikawa T, Fujita Y, Yamashita T, Tajima T, Honda M, Nakayama K (2006) Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats. Br J Pharmacol 148:579–586

Molander C, Xu Q, Grant G (1984) The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J Comp Neurol 230:133–141

Guo TZ, Offley SC, Boyd EA, Jacobs CR, Kingery WS (2004) Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I. Pain 108:95–107

Petrat F, Ronn T, de Groot H (2011) Protection by pyruvate infusion in a rat model of severe intestinal ischemia–reperfusion injury. J Surg Res 167:e93–e101

Coderre TJ, Bennett GJ (2010) A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology. Pain Med 11:1224–1238

Birklein F, Weber M, Neundorfer B (2000) Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia? Neurology 55:1213–1215

Xu X, Wang P, Zou X, Li D, Fang L, Lin Q (2009) Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation. J Neurosci Res 87:482–494

Hao JX, Kupers RC, Xu XJ (2004) Response characteristics of spinal cord dorsal horn neurons in chronic allodynic rats after spinal cord injury. J Neurophysiol 92:1391–1399

Weng HR, Cordella JV, Dougherty PM (2003) Changes in sensory processing in the spinal dorsal horn accompany vincristine-induced hyperalgesia and allodynia. Pain 103:131–138

Yu Y, Lundeberg T, Yu LC (2002) Role of calcitonin gene-related peptide and its antagonist on the evoked discharge frequency of wide dynamic range neurons in the dorsal horn of the spinal cord in rats. Regul Pept 103:23–27

Yan Y, Yu LC (2004) Involvement of opioid receptors in the CGRP8-37-induced inhibition of the activity of wide-dynamic-range neurons in the spinal dorsal horn of rats. J Neurosci Res 77:148–152

Casey GP, Paul D, Gould HJ 3rd (2010) Insulin is essential for the recovery from allodynia induced by complete Freund’s adjuvant. Pain Med 11:1401–1410

Guo A, Vulchanova L, Wang J, Li X, Elde R (1999) Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11:946–958

Chen Y, Willcockson HH, Valtschanoff JG (2008) Increased expression of CGRP in sensory afferents of arthritic mice—effect of genetic deletion of the vanilloid receptor TRPV1. Neuropeptides 42:551–556

Fernihough J, Gentry C, Bevan S, Winter J (2005) Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Neurosci Lett 388:75–80

Hullugundi SK, Ferrari MD, van den Maagdenberg AM, Nistri A (2013) The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1). PLoS One 8:e60677

Kingery WS (2010) Role of neuropeptide, cytokine, and growth factor signaling in complex regional pain syndrome. Pain Med 11:1239–1250

Imbe H, Murakami S, Okamoto K, Iwai-Liao Y, Senba E (2004) The effects of acute and chronic restraint stress on activation of ERK in the rostral ventromedial medulla and locus coeruleus. Pain 112:361–371

Quintero L, Cuesta MC, Silva JA, Arcaya JL, Pinerua-Suhaibar L, Maixner W, Suarez-Roca H (2003) Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord. Brain Res 965:259–268

Nasu T, Taguchi T, Mizumura K (2009) Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. Eur J Pain 14:236–244

Allen G, Galer BS, Schwartz L (1999) Epidemiology of complex regional pain syndrome: a retrospective chart review of 134 patients. Pain 80:539–544