Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines

Group OLoEW, 2011, Medicine OCfE-B, The Oxford 2011 Levels of Evidence Van Assche, 2010, The second European evidence-based consensus on the diagnosis and management of Crohn's disease: special situations, J Crohns Colitis, 4, 63, 10.1016/j.crohns.2009.09.009 Fletcher, 2011, New concepts in intestinal imaging for inflammatory bowel diseases, Gastroenterology, 140, 1795, 10.1053/j.gastro.2011.02.013 Pariente, 2011, Development of the Crohn's disease digestive damage score, the Lemann score, Inflamm Bowel Dis, 17, 1415, 10.1002/ibd.21506 Pinto, 2011, Comparison of three types of preparations for abdominal sonography, J Clin Ultrasound, 39, 203, 10.1002/jcu.20790 Nylund, 2010, Ultrasound and inflammatory bowel disease, Ultrasound Q, 26, 3, 10.1097/RUQ.0b013e3181ce0929 Strobel, 2011, Diagnostics in inflammatory bowel disease: ultrasound, World J Gastroenterol, 17, 3192 Migaleddu, 2009, Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease, Gastroenterology, 137, 43, 10.1053/j.gastro.2009.03.062 Ripolles, 2009, Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy, Radiology, 253, 241, 10.1148/radiol.2531082269 Gervais, 2002, Percutaneous abscess drainage in Crohn disease: technical success and short- and long-term outcomes during 14 years, Radiology, 222, 645, 10.1148/radiol.2223010554 Rypens, 2007, Percutaneous drainage of abdominal abscesses in pediatric Crohn's disease, AJR Am J Roentgenol, 188, 579, 10.2214/AJR.06.0181 Koral, 2010, Transrectal ultrasound and fluoroscopy-guided drainage of deep pelvic collections in children, J Pediatr Surg, 45, 513, 10.1016/j.jpedsurg.2009.06.033 Karaca, 2004, Liver abscess as a rare complication of Crohn's disease: a case report, Turk J Gastroenterol, 15, 45 Rypens, 2007, The place of interventional radiology in Crohn disease in children, Pediatr Radiol, 37, 1093, 10.1007/s00247-007-0560-8 Allen, 2010, Effect of altering automatic exposure control settings and quality reference mAs on radiation dose, image quality, and diagnostic efficacy in MDCT enterography of active inflammatory Crohn's disease, AJR Am J Roentgenol, 195, 89, 10.2214/AJR.09.3611 Huprich, 2009, CT enterography: principles, technique and utility in Crohn's disease, Eur J Radiol, 69, 393, 10.1016/j.ejrad.2008.11.014 Levi, 2009, Factors associated with radiation exposure in patients with inflammatory bowel disease, Aliment Pharmacol Ther, 30, 1128, 10.1111/j.1365-2036.2009.04140.x Dillman, 2010, CT enterography of pediatric Crohn disease, Pediatr Radiol, 40, 97, 10.1007/s00247-009-1465-5 Vandenbroucke, 2007, Noninvasive multidetector computed tomography enterography in patients with small-bowel Crohn's disease: is a 40-second delay better than 70 seconds?, Acta Radiol, 10, 1 Feuerbach, 2010, MRI enterography: the future of small bowel diagnostics?, Dig Dis, 28, 433, 10.1159/000320399 Kuehle, 2006, Hydro-MRI of the small bowel: effect of contrast volume, timing of contrast administration, and data acquisition on bowel distention, AJR Am J Roentgenol, 187, W375, 10.2214/AJR.05.1079 Siddiki, 2009, Prospective comparison of state-of-the-art MR enterography and CT enterography in small-bowel Crohn's disease, AJR Am J Roentgenol, 193, 113, 10.2214/AJR.08.2027 Hara, 2009, CT enterography of Crohn's disease, Abdom Imaging, 34, 289, 10.1007/s00261-008-9443-1 Minordi, 2009, CT findings and clinical activity in Crohn's disease, Clin Imaging, 33, 123, 10.1016/j.clinimag.2008.08.021 Minordi, 2011, CT enterography with polyethylene glycol solution vs CT enteroclysis in small bowel disease, Br J Radiol, 84, 112, 10.1259/bjr/71649888 Rubesin, 2003, Radiologic diagnosis of gastrointestinal perforation, Radiol Clin North Am, 41, 1095, 10.1016/S0033-8389(03)00100-3 Zissin, 2009, Abdominal CT findings in small bowel perforation, Br J Radiol, 82, 162, 10.1259/bjr/78772574 Coakley, 2011, CT radiation dose: what can you do right now in your practice?, AJR Am J Roentgenol, 196, 619, 10.2214/AJR.10.5043 Silva, 2010, Innovations in CT dose reduction strategy: application of the adaptive statistical iterative reconstruction algorithm, AJR Am J Roentgenol, 194, 191, 10.2214/AJR.09.2953 Garcia, 2001, Abscesses in Crohn's disease: outcome of medical versus surgical treatment, J Clin Gastroenterol, 32, 409, 10.1097/00004836-200105000-00010 Lambiase, 1988, Percutaneous drainage of abscesses in patients with Crohn disease, AJR Am J Roentgenol, 150, 1043, 10.2214/ajr.150.5.1043 Sahai, 1997, Percutaneous drainage of intra-abdominal abscesses in Crohn's disease: short and long-term outcome, Am J Gastroenterol, 92, 275 Jawhari, 1998, Intra-abdominal and pelvic abscess in Crohn's disease: results of noninvasive and surgical management, Br J Surg, 85, 367, 10.1046/j.1365-2168.1998.00575.x Lee, 2006, Nonsurgical treatment of abdominal or pelvic abscess in consecutive patients with Crohn's disease, Dig Liver Dis, 38, 659, 10.1016/j.dld.2005.12.001 Oussalah, 2010, Diffusion-weighted magnetic resonance without bowel preparation for detecting colonic inflammation in inflammatory bowel disease, Gut, 59, 1056, 10.1136/gut.2009.197665 Panes, 2011, Systematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn's disease, Aliment Pharmacol Ther, 34, 125, 10.1111/j.1365-2036.2011.04710.x Froehlich, 2010, MR motility imaging in Crohn's disease improves lesion detection compared with standard MR imaging, Eur Radiol, 20, 1945, 10.1007/s00330-010-1759-x Menys, 2012, Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn's disease activity: a preliminary study, Eur Radiol, 22, 2494, 10.1007/s00330-012-2514-2 Negaard, 2007, A prospective randomized comparison between two MRI studies of the small bowel in Crohn's disease, the oral contrast method and MR enteroclysis, Eur Radiol, 17, 2294, 10.1007/s00330-007-0648-4 Maccioni, 2012, Differences in the location and activity of intestinal Crohn's disease lesions between adult and paediatric patients detected with MRI, Eur Radiol, 22, 2465, 10.1007/s00330-012-2482-6 Wang, 2001, Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging, Eur Radiol, 11, 2319, 10.1007/s003300100908 Masoudi, 2012, Long-term investigation on the phase stability, magnetic behavior, toxicity, and MRI characteristics of superparamagnetic Fe/Fe-oxide core/shell nanoparticles, Int J Pharm, 439, 28, 10.1016/j.ijpharm.2012.09.050 Lönnemark, 1989, Effect of superparamagnetic particles as oral contrast medium at magnetic resonance imaging. A phase I clinical study, Acta Radiol, 30, 193 Prayer, 1993, Superparamagnetic particles as oral contrast medium in magnetic resonance imaging of patients with treated ovarian cancer—comparison with plain MRI, Br J Radiol, 66, 415, 10.1259/0007-1285-66-785-415 Sahni, 2008, Which method is best for imaging of perianal fistula?, Abdom Imaging, 33, 26, 10.1007/s00261-007-9309-y Schwartz, 2001, A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas, Gastroenterology, 121, 1064, 10.1053/gast.2001.28676 Horsthuis, 2008, Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: meta-analysis of prospective studies, Radiology, 247, 64, 10.1148/radiol.2471070611 Schmidt, 2003, Prospective comparison of MR enteroclysis with multidetector spiral-CT enteroclysis: interobserver agreement and sensitivity by means of “sign-by-sign” correlation, Eur Radiol, 13, 1303, 10.1007/s00330-002-1710-x Annovazzi, 2005, Nuclear medicine imaging of inflammatory/infective disorders of the abdomen, Nucl Med Commun, 26, 657, 10.1097/01.mnm.0000169202.68011.47 Annovazzi, 2003, 99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease, Eur J Nucl Med Mol Imaging, 30, 374, 10.1007/s00259-002-1069-x Arndt, 1997, Inflammatory bowel disease activity assessment using technetium-99m-HMPAO leukocytes, Dig Dis Sci, 42, 387, 10.1023/A:1018834406637 Carrera, 2006, Prognostic utility of scintigraphy with 99mTc-HMPAO labelled leukocytes in inflammatory bowel disease, Rev Esp Med Nucl, 25, 380, 10.1157/13095993 Charron, 2000, Are 99mTc leukocyte scintigraphy and SBFT studies useful in children suspected of having inflammatory bowel disease?, Am J Gastroenterol, 95, 1208, 10.1111/j.1572-0241.2000.02011.x Gotthardt, 2010, Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques, J Nucl Med, 51, 1937, 10.2967/jnumed.110.076232 Jobling, 1996, Investigating inflammatory bowel disease—white cell scanning, radiology, and colonoscopy, Arch Dis Child, 74, 22, 10.1136/adc.74.1.22 Scholmerich, 1988, Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label, Gastroenterology, 95, 1287, 10.1016/0016-5085(88)90363-0 Segarra, 1991, Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indium-111 oxine-labelled leucocyte scintigraphy in inflammatory bowel disease, Eur J Nucl Med, 18, 715, 10.1007/BF00956711 Stathaki, 2009, Role of scintigraphy in inflammatory bowel disease, World J Gastroenterol, 15, 2693, 10.3748/wjg.15.2693 Health risks from exposure to low levels of ionizing radiation: BEIR VII Phase 2, 2006, Division on Earth and Life Studies, Committee to assess health risks from exposure to low levels of ionizing radiation BoRER Charron, 2000, Pediatric inflammatory bowel disease imaged with Tc-99m white blood cells, Clin Nucl Med, 25, 708, 10.1097/00003072-200009000-00012 Bennink, 2004, Evaluation of early treatment response and predicting the need for colectomy in active ulcerative colitis with 99mTc-HMPAO white blood cell scintigraphy, J Nucl Med, 45, 1698 Biancone, 1997, 99mTc-HMPAO granulocyte scintigraphy in the early detection of postoperative asymptomatic recurrence in Crohn's disease, Dig Dis Sci, 42, 1549, 10.1023/A:1018843516651 Loffler, 2006, High diagnostic value of 18F-FDG-PET in pediatric patients with chronic inflammatory bowel disease, Ann N Y Acad Sci, 1072, 379, 10.1196/annals.1326.014 Louis, 2007, Noninvasive assessment of Crohn's disease intestinal lesions with (18)F-FDG PET/CT, J Nucl Med, 48, 1053, 10.2967/jnumed.107.040436 Groshar, 2010, PET/CT enterography in Crohn disease: correlation of disease activity on CT enterography with 18F-FDG uptake, J Nucl Med, 51, 1009, 10.2967/jnumed.109.073130 Hafeez, 2011, Use of small bowel imaging for the diagnosis and staging of Crohn's disease—a survey of current UK practice, Br J Radiol, 84, 508, 10.1259/bjr/65972479 Marshall, 2004, Prospective comparison of small bowel meal with pneumocolon versus ileo-colonoscopy for the diagnosis of ileal Crohn's disease, Am J Gastroenterol, 99, 1321, 10.1111/j.1572-0241.2004.30499.x Thoeni, 1991, Enteroclysis and small bowel series: comparison of radiation dose and examination time, Radiology, 178, 659, 10.1148/radiology.178.3.1994398 Jaffe, 2007, Radiation doses from small-bowel follow-through and abdominopelvic MDCT in Crohn's disease, AJR Am J Roentgenol, 189, 1015, 10.2214/AJR.07.2427 Gaca, 2008, Radiation doses from small-bowel follow-through and abdomen/pelvis MDCT in pediatric Crohn disease, Pediatr Radiol, 38, 285, 10.1007/s00247-007-0702-z Cirillo, 2000, Accuracy of enteroclysis in Crohn's disease of the small bowel: a retrospective study, Eur Radiol, 10, 1894, 10.1007/s003300000473 Rajesh, 2009, Comparison of capsule endoscopy with enteroclysis in the investigation of small bowel disease, Abdom Imaging, 34, 459, 10.1007/s00261-008-9427-1 Solem, 2008, Small-bowel imaging in Crohn's disease: a prospective, blinded, 4-way comparison trial, Gastrointest Endosc, 68, 255, 10.1016/j.gie.2008.02.017 Bernstein, 1997, A prospective randomized comparison between small bowel enteroclysis and small bowel follow-through in Crohn's disease, Gastroenterology, 113, 390, 10.1053/gast.1997.v113.pm9247455 Maconi, 2003, Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn's disease: a prospective comparative study, Am J Gastroenterol, 98, 1545, 10.1111/j.1572-0241.2003.07521.x Lee, 2009, Crohn disease of the small bowel: comparison of CT enterography, MR enterography, and small-bowel follow-through as diagnostic techniques, Radiology, 251, 751, 10.1148/radiol.2513081184 Lameris, 2009, Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study, BMJ, 338, b2431, 10.1136/bmj.b2431 Craig, 2012, Diagnostic accuracy of computed tomography using lower doses of radiation for patients with Crohn's disease, Clin Gastroenterol Hepatol, 10, 886, 10.1016/j.cgh.2012.03.014 Kambadakone, 2010, Low-dose CT examinations in Crohn's disease: impact on image quality, diagnostic performance, and radiation dose, AJR Am J Roentgenol, 195, 78, 10.2214/AJR.09.3420 Langmead, 2002, Plain abdominal radiographic features are not reliable markers of disease extent in active ulcerative colitis, Am J Gastroenterol, 97, 354, 10.1111/j.1572-0241.2002.05469.x Prantera, 1991, The plain abdominal film accurately estimates extent of active ulcerative colitis, J Clin Gastroenterol, 13, 231, 10.1097/00004836-199104000-00024 Almer, 1995, Plain X-ray films and air enema films reflect severe mucosal inflammation in acute ulcerative colitis, Digestion, 56, 528, 10.1159/000201287 Markus, 1989, Interobserver variation in the interpretation of abdominal radiographs, Radiology, 171, 69, 10.1148/radiology.171.1.2928547 Megibow, 1991, Bowel obstruction: evaluation with CT, Radiology, 180, 313, 10.1148/radiology.180.2.2068291 Mucha, 1987, Small intestinal obstruction, Surg Clin North Am, 67, 597, 10.1016/S0039-6109(16)44234-9 Earls, 1993, Prevalence and duration of postoperative pneumoperitoneum: sensitivity of CT vs left lateral decubitus radiography, AJR Am J Roentgenol, 161, 781, 10.2214/ajr.161.4.8372757 Stapakis, 1992, Diagnosis of pneumoperitoneum: abdominal CT vs. upright chest film, J Comput Assist Tomogr, 16, 713, 10.1097/00004728-199209000-00008 Gatta, 2012, Crohn's disease imaging: a review, Gastroenterol Res Pract, 2012, 816920, 10.1155/2012/816920 Valentin, 1999, Annals of the ICRP, publication 80, radiation dose to patients from radiopharmaceuticals, 67 Hall, 2008, Cancer risks from diagnostic radiology, Br J Radiol, 81, 362, 10.1259/bjr/01948454 Desmond, 2012, Radiation exposure from diagnostic imaging among patients with gastrointestinal disorders, Clin Gastroenterol Hepatol, 10, 259, 10.1016/j.cgh.2011.11.007 Kroeker, 2011, Patients with IBD are exposed to high levels of ionizing radiation through CT scan diagnostic imaging: a five-year study, J Clin Gastroenterol, 45, 34, 10.1097/MCG.0b013e3181e5d1c5 Chatu, 2012, Meta-analysis: diagnostic medical radiation exposure in inflammatory bowel disease, Aliment Pharmacol Ther, 35, 529, 10.1111/j.1365-2036.2011.04975.x Desmond, 2008, Crohn's disease: factors associated with exposure to high levels of diagnostic radiation, Gut, 57, 1524, 10.1136/gut.2008.151415 Marin, 2006, Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images, J Magn Reson Imaging, 24, 690, 10.1002/jmri.20660 Ott, 1985, Detailed per-oral small bowel examination vs. enteroclysis. Part II: Radiographic accuracy, Radiology, 155, 31, 10.1148/radiology.155.1.3975414 Masselli, 2006, Assessment of Crohn's disease in the small bowel: prospective comparison of magnetic resonance enteroclysis with conventional enteroclysis, Eur Radiol, 16, 2817, 10.1007/s00330-006-0338-7 Ott, 1985, Detailed per-oral small bowel examination vs. enteroclysis. Part I: expenditures and radiation exposure, Radiology, 155, 29, 10.1148/radiology.155.1.3975413 Maglinte, 1992, Crohn disease of the small intestine: accuracy and relevance of enteroclysis, Radiology, 184, 541, 10.1148/radiology.184.2.1620862 Wills, 1997, Crohn disease: state of the art, Radiology, 202, 597, 10.1148/radiology.202.3.9051003 Masselli, 2008, Comparison of MR enteroclysis with MR enterography and conventional enteroclysis in patients with Crohn's disease, Eur Radiol, 18, 438, 10.1007/s00330-007-0763-2 Di Mizio, 2004, Small bowel Crohn disease: sonographic features, Abdom Imaging, 29, 23, 10.1007/s00261-003-0087-x Holt, 1979, Grey scale ultrasound in Crohn's disease, Gut, 20, 590, 10.1136/gut.20.7.590 Maconi, 2006, Bowel ultrasound in Crohn's disease, Best Pract Res Clin Gastroenterol, 20, 93, 10.1016/j.bpg.2005.09.001 Parente, 2004, Modern imaging of Crohn's disease using bowel ultrasound, Inflamm Bowel Dis, 10, 452, 10.1097/00054725-200407000-00022 Fraquelli, 2005, Role of US in detection of Crohn disease: meta-analysis, Radiology, 236, 95, 10.1148/radiol.2361040799 Calabrese, 2005, Crohn's disease: a comparative prospective study of transabdominal ultrasonography, small intestine contrast ultrasonography, and small bowel enema, Inflamm Bowel Dis, 11, 139, 10.1097/00054725-200502000-00007 Parente, 2004, Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn's disease. A prospective comparison with conventional ultrasound, X ray studies, and ileocolonoscopy, Gut, 53, 1652, 10.1136/gut.2004.041038 Chiorean, 2007, Correlation of CT enteroclysis with surgical pathology in Crohn's disease, Am J Gastroenterol, 102, 2541, 10.1111/j.1572-0241.2007.01537.x Tillack, 2008, Correlation of magnetic resonance enteroclysis (MRE) and wireless capsule endoscopy (CE) in the diagnosis of small bowel lesions in Crohn's disease, Inflamm Bowel Dis, 14, 1219, 10.1002/ibd.20466 Voderholzer, 2005, Small bowel involvement in Crohn's disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis, Gut, 54, 369, 10.1136/gut.2004.040055 Gourtsoyiannis, 2006, Magnetic resonance imaging evaluation of small intestinal Crohn's disease, Best Pract Res Clin Gastroenterol, 20, 137, 10.1016/j.bpg.2005.09.002 Charron, 1999, Technetium leukocyte imaging in inflammatory bowel disease, Curr Gastroenterol Rep, 1, 245, 10.1007/s11894-999-0042-2 Grassi, 2011, Inflammatory bowel disease: value in diagnosis and management of MDCT-enteroclysis and 99mTc-HMPAO labeled leukocyte scintigraphy, Abdom Imaging, 36, 372, 10.1007/s00261-010-9652-2 Groshar, 2010, PET/CT enterography in Crohn disease: correlation of disease activity on CT enterography with 18F-FDG uptake, J Nucl Med, 51, 1009, 10.2967/jnumed.109.073130 Parente, 2002, Bowel ultrasound in assessment of Crohn's disease and detection of related small bowel strictures: a prospective comparative study versus X ray and intraoperative findings, Gut, 50, 490, 10.1136/gut.50.4.490 Ochsenkuhn, 2004, Crohn disease of the small bowel proximal to the terminal ileum: detection by MR-enteroclysis, Scand J Gastroenterol, 39, 953, 10.1080/00365520410003218 Zappa, 2011, Which magnetic resonance imaging findings accurately evaluate inflammation in small bowel Crohn's disease? A retrospective comparison with surgical pathologic analysis, Inflamm Bowel Dis, 17, 984, 10.1002/ibd.21414 Fiorino, 2011, Prospective comparison of computed tomography enterography and magnetic resonance enterography for assessment of disease activity and complications in ileocolonic Crohn's disease, Inflamm Bowel Dis, 17, 1073, 10.1002/ibd.21533 Turetschek, 2002, Findings at helical CT-enteroclysis in symptomatic patients with crohn disease: correlation with endoscopic and surgical findings, J Comput Assist Tomogr, 26, 488, 10.1097/00004728-200207000-00002 Wiarda, 2012, Small bowel Crohn's disease: MR enteroclysis and capsule endoscopy compared to balloon-assisted enteroscopy, Abdom Imaging, 37, 397, 10.1007/s00261-011-9816-8 Girlich, 2011, Comparison between preoperative quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and operative macroscopic findings and results of histopathological scoring in Crohn's disease, Ultraschall Med, 32, 154, 10.1055/s-0029-1245398 Schirin-Sokhan, 2011, Assessment of inflammatory and fibrotic stenoses in patients with Crohn's disease using contrast-enhanced ultrasound and computerized algorithm: a pilot study, Digestion, 83, 263, 10.1159/000321389 Adler, 2011, Computed tomography enterography findings correlate with tissue inflammation, not fibrosis in resected small bowel Crohn's disease, Inflamm Bowel Dis, 18, 849, 10.1002/ibd.21801 Punwani, 2009, Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features, Radiology, 252, 712, 10.1148/radiol.2523082167 Louis, 2001, Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease, Gut, 49, 777, 10.1136/gut.49.6.777 Vogel, 2007, CT enterography for Crohn's disease: accurate preoperative diagnostic imaging, Dis Colon Rectum, 50, 1761, 10.1007/s10350-007-9005-6 Booya, 2009, CT enterography and fistulizing Crohn's disease: clinical benefit and radiographic findings, Abdom Imaging, 34, 467, 10.1007/s00261-008-9419-1 Gourtsoyiannis, 2006, Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis, Eur Radiol, 16, 1915, 10.1007/s00330-006-0248-8 Wold, 2003, Assessment of small bowel Crohn disease: noninvasive peroral CT enterography compared with other imaging methods and endoscopy—feasibility study, Radiology, 229, 275, 10.1148/radiol.2291020877 Maccioni, 2006, MR imaging in patients with Crohn disease: value of T2- versus T1-weighted gadolinium-enhanced MR sequences with use of an oral superparamagnetic contrast agent, Radiology, 238, 517, 10.1148/radiol.2381040244 Martinez, 2009, Assessment of the extension and the inflammatory activity in Crohn's disease: comparison of ultrasound and MRI, Abdom Imaging, 34, 141, 10.1007/s00261-008-9365-y Pilleul, 2005, Magnetic resonance imaging in Crohn's disease, Gastroenterol Clin Biol, 29, 803, 10.1016/S0399-8320(05)86351-1 Moisan, 1990, Imaging of inflammatory bowel disease (IBD) and scintigraphic assessment of resected colon: comparison of 111 In-oxine and 99mTC HMPAO leucocyte labelling, Prog Clin Biol Res, 355, 159 Cosnes, 2011, Epidemiology and natural history of inflammatory bowel diseases, Gastroenterology, 140, 1785, 10.1053/j.gastro.2011.01.055 Turner, 2009, Esophageal, gastric, and duodenal manifestations of IBD and the role of upper endoscopy in IBD diagnosis, Curr Gastroenterol Rep, 11, 234, 10.1007/s11894-009-0036-0 Attwood, 2008, Eosinophilic oesophagitis and other non-reflux inflammatory conditions of the oesophagus: diagnostic imaging and management, Best Pract Res Clin Gastroenterol, 22, 639, 10.1016/j.bpg.2007.12.003 Clarke, 2010, Crohn's disease of the esophagus with esophagobronchial fistula formation: a case report and review of the literature, Gastrointest Endosc, 71, 207, 10.1016/j.gie.2009.06.012 Quaia, 2009, The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment, Eur J Radiol, 69, 438, 10.1016/j.ejrad.2008.10.029 Paredes, 2010, Abdominal sonographic changes after antibody to tumor necrosis factor (anti-TNF) alpha therapy in Crohn's Disease, Dig Dis Sci, 55, 404, 10.1007/s10620-009-0759-7 Bruining, 2011, Computed tomography enterography detects intestinal wall changes and effects of treatment in patients with Crohn's disease, Clin Gastroenterol Hepatol, 9, 679, 10.1016/j.cgh.2011.04.025 Echarri, 2010, Evaluation of stricturing ileal Crohn's disease by magnetic resonance and ileoscopy: influence of disease duration and surgery, J Crohns Colitis, 4, S98 Ahmadi, 2010, Diagnostic value of noninvasive combined fluorine-18 labeled fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography enterography in active Crohn's disease, Inflamm Bowel Dis, 16, 974, 10.1002/ibd.21153 Jacene, 2009, Prediction of the need for surgical intervention in obstructive Crohn's disease by 18F-FDG PET/CT, J Nucl Med, 50, 1751, 10.2967/jnumed.109.065466 Bru, 2001, Hydrocolonic sonography for evaluating inflammatory bowel disease, AJR Am J Roentgenol, 177, 99, 10.2214/ajr.177.1.1770099 Schreyer, 2005, Dark lumen magnetic resonance enteroclysis in combination with MRI colonography for whole bowel assessment in patients with Crohn's disease: first clinical experience, Inflamm Bowel Dis, 11, 388, 10.1097/01.MIB.0000164022.72729.06 Ajaj, 2005, Magnetic resonance colonography without bowel cleansing using oral and rectal stool softeners (fecal cracking)—a feasibility study, Eur Radiol, 15, 2079, 10.1007/s00330-005-2838-2 Oussalah, 2010, Diffusion-weighted magnetic resonance without bowel preparation for detecting colonic inflammation in inflammatory bowel disease, Gut, 59, 1056, 10.1136/gut.2009.197665 Rimola, 2011, Magnetic resonance imaging for evaluation of Crohn's disease: validation of parameters of severity and quantitative index of activity, Inflamm Bowel Dis, 17, 1759, 10.1002/ibd.21551 Rimola, 2009, Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease, Gut, 58, 1113, 10.1136/gut.2008.167957 Parente, 2003, Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel, Aliment Pharmacol Ther, 18, 1009, 10.1046/j.1365-2036.2003.01796.x Fiorino, 2011, MRI in Crohn's disease--current and future clinical applications, Nat Rev Gastroenterol Hepatol, 9, 23, 10.1038/nrgastro.2011.214 Pascu, 2004, Clinical relevance of transabdominal ultrasonography and magnetic resonance imaging in patients with inflammatory bowel disease of the terminal ileum and large bowel, Inflamm Bowel Dis, 10, 373, 10.1097/00054725-200407000-00008 Low, 2002, Crohn disease with endoscopic correlation: single-shot fast spin-echo and gadolinium-enhanced fat-suppressed spoiled gradient-echo MR imaging, Radiology, 222, 652, 10.1148/radiol.2223010811 Bremner, 2006, Sonographic evaluation of inflammatory bowel disease: a prospective, blinded, comparative study, Pediatr Radiol, 36, 947, 10.1007/s00247-006-0245-8 Reimund, 1999, Diagnostic value of high resolution sonography in Crohn's disease and ulcerative colitis, Gastroenterol Clin Biol, 23, 740 Miao, 2002, Ultrasound and magnetic resonance imaging assessment of active bowel segments in Crohn's disease, Clin Radiol, 57, 913, 10.1053/crad.2002.1059 Pradel, 1997, Sonographic assessment of the normal and abnormal bowel wall in nondiverticular ileitis and colitis, Abdom Imaging, 22, 167, 10.1007/s002619900164 Esteban, 2003, Contrast-enhanced power Doppler ultrasound in the diagnosis and follow-up of inflammatory abdominal masses in Crohn's disease, Eur J Gastroenterol Hepatol, 15, 253, 10.1097/00042737-200303000-00008 Kratzer, 2002, Contrast-enhanced power Doppler sonography of the intestinal wall in the differentiation of hypervascularized and hypovascularized intestinal obstructions in patients with Crohn's disease, J Ultrasound Med, 21, 149, 10.7863/jum.2002.21.2.149 Spalinger, 2000, Doppler US in patients with Crohn disease: vessel density in the diseased bowel reflects disease activity, Radiology, 217, 787, 10.1148/radiology.217.3.r00dc19787 Maconi, 1996, Abdominal ultrasound in the assessment of extent and activity of Crohn's disease: clinical significance and implication of bowel wall thickening, Am J Gastroenterol, 91, 1604 Neye, 2004, Evaluation of criteria for the activity of Crohn's disease by power Doppler sonography, Dig Dis, 22, 67, 10.1159/000078737 Futagami, 1999, Development and validation of an ultrasonographic activity index of Crohn's disease, Eur J Gastroenterol Hepatol, 11, 1007, 10.1097/00042737-199909000-00010 Haber, 2002, Ultrasonographic findings correspond to clinical, endoscopic, and histologic findings in inflammatory bowel disease and other enterocolitides, J Ultrasound Med, 21, 375, 10.7863/jum.2002.21.4.375 Ordas, 2012, Imaging of the colon in inflammatory bowel disease: ready for prime time?, Curr Drug Targets, 13, 1252, 10.2174/138945012802429714 Parente, 2010, Are colonoscopy and bowel ultrasound useful for assessing response to short-term therapy and predicting disease outcome of moderate-to-severe forms of ulcerative colitis?: a prospective study, Am J Gastroenterol, 105, 1150, 10.1038/ajg.2009.672 Andersen, 2006, Multi-detector CT-colonography in inflammatory bowel disease: prospective analysis of CT-findings to high-resolution video colonoscopy, Eur J Radiol, 58, 140, 10.1016/j.ejrad.2005.11.004 Low, 2000, Crohn's disease evaluation: comparison of contrast-enhanced MR imaging and single-phase helical CT scanning, J Magn Reson Imaging, 11, 127, 10.1002/(SICI)1522-2586(200002)11:2<127::AID-JMRI8>3.0.CO;2-G Biancone, 2003, Virtual colonoscopy compared with conventional colonoscopy for stricturing postoperative recurrence in Crohn's disease, Inflamm Bowel Dis, 9, 343, 10.1097/00054725-200311000-00001 Johnson, 2009, Evaluation of colitis: usefulness of CT enterography technique, Emerg Radiol, 16, 277, 10.1007/s10140-008-0776-4 Fletcher, 2011, New concepts in intestinal imaging for inflammatory bowel diseases, Gastroenterology, 140, 1795, 10.1053/j.gastro.2011.02.013 Meisner, 2007, Pilot study using PET/CT as a novel, noninvasive assessment of disease activity in inflammatory bowel disease, Inflamm Bowel Dis, 13, 993, 10.1002/ibd.20134 Das, 2009, PET/CT colonography: a novel non-invasive technique for assessment of extent and activity of ulcerative colitis, Eur J Nucl Med Mol Imaging, 37, 714, 10.1007/s00259-009-1335-2 Triester, 2006, A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn's disease, Am J Gastroenterol, 101, 954, 10.1111/j.1572-0241.2006.00506.x Stange, 2008, European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis, J Crohns Colitis, 2, 1, 10.1016/j.crohns.2007.11.001 Neurath, 2002, Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies, Am J Gastroenterol, 97, 1978, 10.1111/j.1572-0241.2002.05836.x Koh, 2001, MR imaging evaluation of the activity of Crohn's disease, AJR Am J Roentgenol, 177, 1325, 10.2214/ajr.177.6.1771325 Florie, 2005, Magnetic resonance imaging compared with ileocolonoscopy in evaluating disease severity in Crohn's disease, Clin Gastroenterol Hepatol, 3, 1221, 10.1016/S1542-3565(05)00853-0 van Gemert-Horsthuis, 2006, Feasibility of evaluating Crohn's disease activity at 3.0 Tesla, J Magn Reson Imaging, 24, 340, 10.1002/jmri.20650 Hyun, 2011, Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease, Inflamm Bowel Dis, 17, 1063, 10.1002/ibd.21510 Giovagnoni, 1993, MR imaging of ulcerative colitis, Abdom Imaging, 18, 371, 10.1007/BF00201786 Madsen, 1998, Active Crohn's disease and ulcerative colitis evaluated by low-field magnetic resonance imaging, Scand J Gastroenterol, 33, 1193, 10.1080/00365529850172566 Nozue, 2000, Assessment of disease activity and extent by magnetic resonance imaging in ulcerative colitis, Pediatr Int, 42, 285, 10.1046/j.1442-200x.2000.01218.x Laghi, 2003, Contrast enhanced magnetic resonance imaging of the terminal ileum in children with Crohn's disease, Gut, 52, 393, 10.1136/gut.52.3.393 Ajaj, 2005, Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity, Gut, 54, 257, 10.1136/gut.2003.037085 Horsthuis, 2010, Magnetic resonance enterography for suspected inflammatory bowel disease in a pediatric population, J Pediatr Gastroenterol Nutr, 51, 603, 10.1097/MPG.0b013e3181dee5bd Paolantonio, 2009, Current status of MR imaging in the evaluation of IBD in a pediatric population of patients, Eur J Radiol, 69, 418, 10.1016/j.ejrad.2008.11.023 Langhorst, 2007, MR colonography without bowel purgation for the assessment of inflammatory bowel diseases: diagnostic accuracy and patient acceptance, Inflamm Bowel Dis, 13, 1001, 10.1002/ibd.20140 Maccioni, 2005, Ulcerative colitis: value of MR imaging, Abdom Imaging, 30, 584, 10.1007/s00261-004-0284-2 Lantto, 1992, Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease, Eur J Nucl Med, 19, 14, 10.1007/BF00178302 Gasche, 1999, Transabdominal bowel sonography for the detection of intestinal complications in Crohn's disease, Gut, 44, 112, 10.1136/gut.44.1.112 Maconi, 1996, Ultrasonographic detection of intestinal complications in Crohn's disease, Dig Dis Sci, 41, 1643, 10.1007/BF02087914 Magnano, 2003, Polyethylene glycol and contrast-enhanced MRI of Crohn's disease in children: preliminary experience, Pediatr Radiol, 33, 385, 10.1007/s00247-003-0903-z Parente, 2009, Bowel ultrasound and mucosal healing in ulcerative colitis, Dig Dis, 27, 285, 10.1159/000228562 Bruining, 2011, Computed tomography enterography detects intestinal wall changes and effects of treatment in patients with Crohn's disease, Clin Gastroenterol Hepatol, 9, 679, 10.1016/j.cgh.2011.04.025 Tozer, 2011, Review article: medical, surgical and radiological management of perianal Crohn's fistulas, Aliment Pharmacol Ther, 33, 5, 10.1111/j.1365-2036.2010.04486.x Beets-Tan, 2001, Preoperative MR imaging of anal fistulas: does it really help the surgeon?, Radiology, 218, 75, 10.1148/radiology.218.1.r01dc0575 Buchanan, 2002, Effect of MRI on clinical outcome of recurrent fistula-in-ano, Lancet, 360, 1661, 10.1016/S0140-6736(02)11605-9 Buchanan, 2004, Clinical examination, endosonography, and MR imaging in preoperative assessment of fistula in ano: comparison with outcome-based reference standard, Radiology, 233, 674, 10.1148/radiol.2333031724 Navarro-Luna, 2004, Ultrasound study of anal fistulas with hydrogen peroxide enhancement, Dis Colon Rectum, 47, 108, 10.1007/s10350-003-0015-8 Sudol-Szopinska, 2003, Usefulness of hydrogen peroxide enhancement in diagnosis of anal and ano-vaginal fistulas, Eur Radiol, 13, 1080, 10.1007/s00330-002-1560-6 Wedemeyer, 2004, Transcutaneous perianal sonography: a sensitive method for the detection of perianal inflammatory lesions in Crohn's disease, World J Gastroenterol, 10, 2859, 10.3748/wjg.v10.i19.2859 West, 2004, Hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging in evaluating perianal fistulas: agreement and patient preference, Eur J Gastroenterol Hepatol, 16, 1319, 10.1097/00042737-200412000-00014 Schaefer, 2005, Differentiation of perianal fistulas with digital subtraction magnetic resonance fistulography, Inflamm Bowel Dis, 11, 383, 10.1097/01.MIB.0000164021.65106.cd Fernandez-Frias, 2006, Is anal endosonography useful in the study of recurrent complex fistula-in-ano?, Rev Esp Enferm Dig, 98, 573, 10.4321/S1130-01082006000800002 Maier, 2001, Evaluation of perianal sepsis: comparison of anal endosonography and magnetic resonance imaging, J Magn Reson Imaging, 14, 254, 10.1002/jmri.1181 Horsthuis, 2009, Perianal Crohn disease: evaluation of dynamic contrast-enhanced MR imaging as an indicator of disease activity, Radiology, 251, 380, 10.1148/radiol.2512072128 Reginelli, 2012, Three-dimensional anal endosonography in depicting anal-canal anatomy, Radiol Med, 117, 759, 10.1007/s11547-011-0768-4 Mallouhi, 2004, Detection and characterization of perianal inflammatory disease: accuracy of transperineal combined gray scale and color Doppler sonography, J Ultrasound Med, 23, 19, 10.7863/jum.2004.23.1.19 Spencer, 1998, Outcome after surgery for perianal fistula: predictive value of MR imaging, AJR Am J Roentgenol, 171, 403, 10.2214/ajr.171.2.9694464 van Bodegraven, 2002, Endosonographic evidence of persistence of Crohn's disease-associated fistulas after infliximab treatment, irrespective of clinical response, Dis Colon Rectum, 45, 39, 10.1007/s10350-004-6111-6 Tonolini, 2011, Ileal pouch and related complications: spectrum of imaging findings with emphasis on MRI, Abdom Imaging, 36, 698, 10.1007/s00261-011-9693-1 Irvine, 1995, Usual therapy improves perianal Crohn's disease as measured by a new disease activity index. McMaster IBD Study Group, J Clin Gastroenterol, 20, 27, 10.1097/00004836-199501000-00008 Sandborn, 2002, A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease, Gastroenterology, 122, 512, 10.1053/gast.2002.31072 Hinojosa, 2007, Efficacy and safety of short-term adalimumab treatment in patients with active Crohn's disease who lost response or showed intolerance to infliximab: a prospective, open-label, multicentre trial, Aliment Pharmacol Ther, 25, 409, 10.1111/j.1365-2036.2006.03232.x Schoepfer, 2010, Efficacy and safety of certolizumab pegol induction therapy in an unselected Crohn's disease population: results of the FACTS survey, Inflamm Bowel Dis, 16, 933, 10.1002/ibd.21127 Sands, 2004, Infliximab maintenance therapy for fistulizing Crohn's disease, N Engl J Med, 350, 876, 10.1056/NEJMoa030815 Sandborn, 2003, Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial, Gastroenterology, 125, 380, 10.1016/S0016-5085(03)00877-1 Pikarsky, 2002, Perianal Crohn disease: a new scoring system to evaluate and predict outcome of surgical intervention, Arch Surg, 137, 774, 10.1001/archsurg.137.7.774 Van Assche, 2003, Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease, Am J Gastroenterol, 98, 332, 10.1016/S0002-9270(02)05909-9 Ng, 2009, Prospective evaluation of anti-tumor necrosis factor therapy guided by magnetic resonance imaging for Crohn's perineal fistulas, Am J Gastroenterol, 104, 2973, 10.1038/ajg.2009.509 Schwartz, 2005, Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn's perianal fistulas, Inflamm Bowel Dis, 11, 727, 10.1097/01.MIB.0000172811.57242.18 Spradlin, 2008, A randomized prospective trial of endoscopic ultrasound to guide combination medical and surgical treatment for Crohn's perianal fistulas, Am J Gastroenterol, 103, 2527, 10.1111/j.1572-0241.2008.02063.x Weisman, 2008, Prognostic value of endoanal ultrasound for fistula-in-ano: a retrospective analysis, Dis Colon Rectum, 51, 1089, 10.1007/s10350-008-9284-6 Halligan, 2003, MR imaging of fistula-in-ano, Eur J Radiol, 47, 98, 10.1016/S0720-048X(03)00162-1 Colombel, 2007, Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial, Gastroenterology, 132, 52, 10.1053/j.gastro.2006.11.041 Karmiris, 2011, Long-term monitoring of infliximab therapy for perianal fistulizing Crohn's disease by using magnetic resonance imaging, Clin Gastroenterol Hepatol, 9, 130, 10.1016/j.cgh.2010.10.022 Savoye-Collet, 2011, Fistulizing perianal Crohn's disease: contrast-enhanced magnetic resonance imaging assessment at 1 year on maintenance anti-TNF-alpha therapy, Inflamm Bowel Dis, 17, 1751, 10.1002/ibd.21568 Guidi, 2008, Combined therapy with infliximab and seton drainage for perianal fistulizing Crohn's disease with anal endosonographic monitoring: a single-centre experience, Tech Coloproctol, 12, 111, 10.1007/s10151-008-0411-0 Devon, 2009, Cancer of the anus complicating perianal Crohn's disease, Dis Colon Rectum, 52, 211, 10.1007/DCR.0b013e318197d0ad Hama, 2006, Mucinous adenocarcinoma arising from fistula in ano: MRI findings, AJR Am J Roentgenol, 187, 517, 10.2214/AJR.05.0011 Lad, 2007, MRI appearance of perianal carcinoma in Crohn's disease, J Magn Reson Imaging, 26, 1659, 10.1002/jmri.21186 Parikh, 2011, Anal carcinomas: the role of endoanal ultrasound and magnetic resonance imaging in staging, response evaluation and follow-up, Eur Radiol, 21, 776, 10.1007/s00330-010-1980-7 2009, EASL Clinical Practice Guidelines: management of cholestatic liver diseases, 51, 237 Gibson, 1986, Bile duct obstruction: radiologic evaluation of level, cause, and tumor resectability, Radiology, 160, 43, 10.1148/radiology.160.1.3520654 Pasanen, 1993, A comparison of ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the differential diagnosis of benign and malignant jaundice and cholestasis, Eur J Surg, 159, 23 Ferrari, 2005, US, MRCP, CCT and ERCP: a comparative study in 131 patients with suspected biliary obstruction, Med Sci Monit, 11, MT8 Anderson, 2008, Detection of biliary duct narrowing and choledocholithiasis: accuracy of portal venous phase multidetector CT, Radiology, 247, 418, 10.1148/radiol.2472070473 Varghese, 1999, A prospective comparison of magnetic resonance cholangiopancreatography with endoscopic retrograde cholangiopancreatography in the evaluation of patients with suspected biliary tract disease, Clin Radiol, 54, 513, 10.1016/S0009-9260(99)90848-6 Dave, 2010, Primary sclerosing cholangitis: meta-analysis of diagnostic performance of MR cholangiopancreatography, Radiology, 256, 387, 10.1148/radiol.10091953 Ledro-Cano, 2007, Suspected choledocholithiasis: endoscopic ultrasound or magnetic resonance cholangio-pancreatography? A systematic review, Eur J Gastroenterol Hepatol, 19, 1007, 10.1097/MEG.0b013e328133f30b Fernandez-Esparrach, 2007, Comparison of endoscopic ultrasonography and magnetic resonance cholangiopancreatography in the diagnosis of pancreatobiliary diseases: a prospective study, Am J Gastroenterol, 102, 1632, 10.1111/j.1572-0241.2007.01333.x Kondo, 2005, Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiography, Eur J Radiol, 54, 271, 10.1016/j.ejrad.2004.07.007 De Lisi, 2011, Endoscopic ultrasonography versus endoscopic retrograde cholangiopancreatography in acute biliary pancreatitis: a systematic review, Eur J Gastroenterol Hepatol, 23, 367, 10.1097/MEG.0b013e3283460129 Heathcote, 2007, Diagnosis and management of cholestatic liver disease, Clin Gastroenterol Hepatol, 5, 776, 10.1016/j.cgh.2007.05.008 Textor, 2002, Three-dimensional magnetic resonance cholangiopancreatography with respiratory triggering in the diagnosis of primary sclerosing cholangitis: comparison with endoscopic retrograde cholangiography, Endoscopy, 34, 984, 10.1055/s-2002-35830 Berstad, 2006, Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis, Clin Gastroenterol Hepatol, 4, 514, 10.1016/j.cgh.2005.10.007 Moff, 2006, Diagnosis of primary sclerosing cholangitis: a blinded comparative study using magnetic resonance cholangiography and endoscopic retrograde cholangiography, Gastrointest Endosc, 64, 219, 10.1016/j.gie.2005.12.034 Rosch, 2002, A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures, Gastrointest Endosc, 55, 870, 10.1067/mge.2002.124206 Silviera, 2009, Complications related to endoscopic retrograde cholangiopancreatography: a comprehensive clinical review, J Gastrointestin Liver Dis, 18, 73 Andriulli, 2007, Incidence rates of post-ERCP complications: a systematic survey of prospective studies, Am J Gastroenterol, 102, 1781, 10.1111/j.1572-0241.2007.01279.x Freeman, 1997, Complications of endoscopic biliary sphincterotomy: a review, Endoscopy, 29, 288, 10.1055/s-2007-1004193 Levy, 2008, Prospective evaluation of advanced molecular markers and imaging techniques in patients with indeterminate bile duct strictures, Am J Gastroenterol, 103, 1263, 10.1111/j.1572-0241.2007.01776.x Boberg, 2006, Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis, J Hepatol, 45, 568, 10.1016/j.jhep.2006.05.010 Aljiffry, 2011, Analytical review of diagnosis and treatment strategies for dominant bile duct strictures in patients with primary sclerosing cholangitis, HPB (Oxford), 13, 79, 10.1111/j.1477-2574.2010.00268.x Wagner, 1996, Endoscopic management of biliary tract strictures in primary sclerosing cholangitis, Endoscopy, 28, 546, 10.1055/s-2007-1005552 Domagk, 2005, Endosonographic and histopathological staging of extrahepatic bile duct cancer: time to leave the present TNM-classification?, Am J Gastroenterol, 100, 594, 10.1111/j.1572-0241.2005.40663.x Charatcharoenwitthaya, 2008, Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis, Hepatology, 48, 1106, 10.1002/hep.22441 Navaneethan, 2010, Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease, Inflamm Bowel Dis, 16, 1598, 10.1002/ibd.21219 Wee, 1985, Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis, Hum Pathol, 16, 719, 10.1016/S0046-8177(85)80158-1 Bjornsson, 2008, The natural history of small-duct primary sclerosing cholangitis, Gastroenterology, 134, 975, 10.1053/j.gastro.2008.01.042 Angulo, 2002, Small-duct primary sclerosing cholangitis: a long-term follow-up study, Hepatology, 35, 1494, 10.1053/jhep.2002.33202 Bjornsson, 2002, Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis, Gut, 51, 731, 10.1136/gut.51.5.731 Broome, 2002, Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC), J Hepatol, 36, 586, 10.1016/S0168-8278(02)00036-3 Zuckerman, 1998, Acute lower intestinal bleeding: part I: clinical presentation and diagnosis, Gastrointest Endosc, 48, 606, 10.1016/S0016-5107(98)70043-4 Strate, 2005, Lower GI, bleeding: epidemiology and diagnosis, Gastroenterol Clin North Am, 34, 643, 10.1016/j.gtc.2005.08.007 Fisher, 2010, The role of endoscopy in the management of obscure GI bleeding, Gastrointest Endosc, 72, 471, 10.1016/j.gie.2010.04.032 Teshima, 2011, Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: an updated meta-analysis, J Gastroenterol Hepatol, 26, 796, 10.1111/j.1440-1746.2010.06530.x Triester, 2005, A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding, Am J Gastroenterol, 100, 2407, 10.1111/j.1572-0241.2005.00274.x Zhang, 2010, Diagnosis of obscure gastrointestinal hemorrhage with capsule endoscopy in combination with multiple-detector computed tomography, J Gastroenterol Hepatol, 25, 75, 10.1111/j.1440-1746.2009.06016.x Yoon, 2006, Acute massive gastrointestinal bleeding: detection and localization with arterial phase multi-detector row helical CT, Radiology, 239, 160, 10.1148/radiol.2383050175 Autenrieth, 2012, Toxic megacolon, Inflamm Bowel Dis, 18, 584, 10.1002/ibd.21847 Benchimol, 2008, Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics, Am J Gastroenterol, 103, 1524, 10.1111/j.1572-0241.2008.01807.x Caprilli, 2008, Historical evolution of the management of severe ulcerative colitis, J Crohns Colitis, 2, 263, 10.1016/j.crohns.2008.03.008 Kumar, 2004, Severe ulcerative colitis: prospective study of parameters determining outcome, J Gastroenterol Hepatol, 19, 1247, 10.1111/j.1440-1746.2004.03486.x Latella, 2002, GI distension in severe ulcerative colitis, Am J Gastroenterol, 97, 1169, 10.1111/j.1572-0241.2002.05691.x O'Regan, 2012, Plain abdominal radiographs in patients with Crohn's disease: radiological findings and diagnostic value, Clin Radiol, 67, 774, 10.1016/j.crad.2012.01.005 Imbriaco, 2001, Toxic megacolon: role of CT in evaluation and detection of complications, Clin Imaging, 25, 349, 10.1016/S0899-7071(01)00330-8 Maconi, 2004, Ultrasonographic detection of toxic megacolon in inflammatory bowel diseases, Dig Dis Sci, 49, 138, 10.1023/B:DDAS.0000011615.64250.6e Freeman, 2002, Spontaneous free perforation of the small intestine in Crohn's disease, Can J Gastroenterol, 16, 23, 10.1155/2002/284958 Werbin, 2003, Free perforation in Crohn's disease, Isr Med Assoc J, 5, 175 Hattori, 2007, Clinicopathologic features of Crohn's disease with free intestinal perforation, Hepatogastroenterology, 54, 135 Maniatis, 2000, Perforation of the alimentary tract: evaluation with computed tomography, Abdom Imaging, 25, 373, 10.1007/s002610000022 Panes, 2011, Systematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn's disease, Aliment Pharmacol Ther, 34, 125, 10.1111/j.1365-2036.2011.04710.x Hyman, 2007, Anastomotic leaks after intestinal anastomosis: it's later than you think, Ann Surg, 245, 254, 10.1097/01.sla.0000225083.27182.85 Khoury, 2009, Abdominal computed tomography for diagnosing postoperative lower gastrointestinal tract leaks, J Gastrointest Surg, 13, 1454, 10.1007/s11605-009-0925-4 Power, 2007, CT assessment of anastomotic bowel leak, Clin Radiol, 62, 37, 10.1016/j.crad.2006.08.004 Broder, 2010, Ileal pouch-anal anastomosis surgery: imaging and intervention for post-operative complications, Radiographics, 30, 221, 10.1148/rg.301095084 Kirat, 2011, Management of leak from the tip of the “J” in ileal pouch-anal anastomosis, Dis Colon Rectum, 54, 454, 10.1007/DCR.0b013e31820481be Kirat, 2011, Pelvic abscess associated with anastomotic leak in patients with ileal pouch-anal anastomosis (IPAA): transanastomotic or CT-guided drainage?, Int J Colorectal Dis, 26, 1469, 10.1007/s00384-011-1272-y Castiglione, 2008, Oral contrast-enhanced sonography for the diagnosis and grading of postsurgical recurrence of Crohn's disease, Inflamm Bowel Dis, 14, 1240, 10.1002/ibd.20469 Castiglione, 2004, Bowel wall thickness at abdominal ultrasound and the one-year-risk of surgery in patients with Crohn's disease, Am J Gastroenterol, 99, 1977, 10.1111/j.1572-0241.2004.40267.x Maconi, 2001, Preoperative characteristics and postoperative behavior of bowel wall on risk of recurrence after conservative surgery in Crohn's disease: a prospective study, Ann Surg, 233, 345, 10.1097/00000658-200103000-00007 Parente, 2004, Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn's disease: a prospective study, Aliment Pharmacol Ther, 20, 959, 10.1111/j.1365-2036.2004.02245.x Calabrese, 2009, Severity of postoperative recurrence in Crohn's disease: correlation between endoscopic and sonographic findings, Inflamm Bowel Dis, 15, 1635, 10.1002/ibd.20948 Pallotta, 2010, Ultrasonographic detection and assessment of the severity of Crohn's disease recurrence after ileal resection, BMC Gastroenterol, 10, 69, 10.1186/1471-230X-10-69 Rispo, 2009, Bowel sonography in predicting postoperative course Crohn's disease, Gut, A462 Olivo, 2011, Post surgical recurrence in patients with Crohn's disease: accuracy of abdominal ultrasonography with oral contrast enhancement performed six months after surgery, ECCO congress 2011 Biancone, 2008, Non-invasive techniques for assessing postoperative recurrence in Crohn's disease, Dig Liver Dis, 40, S265, 10.1016/S1590-8658(08)60536-8 Soyer, 2010, Suspected anastomotic recurrence of Crohn disease after ileocolic resection: evaluation with CT enteroclysis, Radiology, 254, 755, 10.1148/radiol.09091165 Minordi, 2009, Enteroclysis CT and PEG-CT in patients with previous small-bowel surgical resection for Crohn's disease: CT findings and correlation with endoscopy, Eur Radiol, 19, 2432, 10.1007/s00330-009-1423-5 Horjus, 2010, Magnetic resonance enterography in the assessment of the disease activity in Crohn's disease. A retrospective study, ECCO Congress, Prague Sailer, 2008, Anastomotic recurrence of Crohn's disease after ileocolic resection: comparison of MR enteroclysis with endoscopy, Eur Radiol, 18, 2512, 10.1007/s00330-008-1034-6 Koilakou, 2010, Endoscopy and MR enteroclysis: equivalent tools in predicting clinical recurrence in patients with Crohn's disease after ileocolic resection, Inflamm Bowel Dis, 16, 198, 10.1002/ibd.21003 Almer, 2007, Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohn's disease, Inflamm Bowel Dis, 13, 164, 10.1002/ibd.20001 Saverymuttu, 1986, Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion, Gastroenterology, 90, 1121, 10.1016/0016-5085(86)90376-8 Saverymuttu, 1985, 111Indium autologous granulocytes in the detection of inflammatory bowel disease, Gut, 26, 955, 10.1136/gut.26.9.955 Saverymuttu, 1985, In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease, Gut, 26, 378, 10.1136/gut.26.4.378 Shen, 2005, Comprehensive evaluation of inflammatory and noninflammatory sequelae of ileal pouch-anal anastomoses, Am J Gastroenterol, 100, 93, 10.1111/j.1572-0241.2005.40778.x Gionchetti, 2003, Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial, Gastroenterology, 124, 1202, 10.1016/S0016-5085(03)00171-9 Hurst, 1998, The implications of acute pouchitis on the long-term functional results after restorative proctocolectomy, Inflamm Bowel Dis, 4, 280, 10.1097/00054725-199811000-00004 Madiba, 2001, Pouchitis following restorative proctocolectomy for ulcerative colitis: incidence and therapeutic outcome, J R Coll Surg Edinb, 46, 334 Mowschenson, 2000, Ileoanal pouch operation: long-term outcome with or without diverting ileostomy, Arch Surg, 135, 463, 10.1001/archsurg.135.4.463 Nadgir, 2006, MRI of complicated pouchitis, AJR Am J Roentgenol, 187, W386, 10.2214/AJR.05.1019 Thoeni, 1990, Ileoanal pouches: comparison of CT, scintigraphy, and contrast enemas for diagnosing postsurgical complications, AJR Am J Roentgenol, 154, 73, 10.2214/ajr.154.1.2104730 Shen, 2010, Asymmetric endoscopic inflammation of the ileal pouch: a sign of ischemic pouchitis?, Inflamm Bowel Dis, 16, 836, 10.1002/ibd.21129 Liu, 2011, Transmural inflammation is not pathognomonic for Crohn's disease of the pouch, Surg Endosc, 25, 3509, 10.1007/s00464-011-1749-3 Farraye, 2010, AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease, Gastroenterology, 138, 746, 10.1053/j.gastro.2009.12.035 Farraye, 2010, AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease, Gastroenterology, 138, 738, 10.1053/j.gastro.2009.12.037 Marion, 2008, Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial, Am J Gastroenterol, 103, 2342, 10.1111/j.1572-0241.2008.01934.x Bernstein, 2001, Cancer risk in patients with inflammatory bowel disease: a population-based study, Cancer, 91, 854, 10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z Lewis, 1999, Cancer risk in patients with inflammatory bowel disease, Gastroenterol Clin North Am, 28, 459, 10.1016/S0889-8553(05)70065-0 von Roon, 2007, The risk of cancer in patients with Crohn's disease, Dis Colon Rectum, 50, 839, 10.1007/s10350-006-0848-z Laghi, 2010, Colorectal cancer screening: the role of CT colonography, World J Gastroenterol, 16, 3987, 10.3748/wjg.v16.i32.3987 Neri, 2013, The second ESGAR consensus statement on CT colonography, Eur Radiol, 23, 720, 10.1007/s00330-012-2632-x Palascak-Juif, 2005, Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo, Inflamm Bowel Dis, 11, 828, 10.1097/01.mib.0000179211.03650.b6