Imaging of Myocardial Oxidative Metabolism in Heart Failure

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Naya M et al. Myocardial oxidative metabolism is increased due to haemodynamic overload in patients with aortic valve stenosis: assessment using 11C-acetate positron emission tomography. Eur J Nucl Med Mol Imaging. 2010;37(12):2242–8. This paper shows an increase in oxidative metabolism in patients with aortic stenosis with its reduction after operation, indicating such an increase in oxidative metabolism in AS largely attributable to the LV pressire overload. (The most important recent report from our group.).

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Wong YY et al. 11C-Acetate clearance as an index of oxygen consumption of the right myocardium in idiopathic pulmonary arterial hypertension: a validation study using 15O-labeled tracers and PET. J Nucl Med. 2013;54(8):1258–62. This is the first report to analyze oxidative metabolism in the right ventricle using PET in patients with idiopathic pulmonary hypertension. (The important recent report from another group.).