Image-guided superficial radiation therapy has superior 2-year recurrence probability to Mohs micrographic surgery

Rogers, 2010, Incidence estimate of nonmelanoma skin cancer in the united states, 2006, Arch Dermatol, 146, 283, 10.1001/archdermatol.2010.19 “Key Statistics for Basal and Squamous Cell Skin Cancers.” Cancer, American Cancer Society, Inc, https://www.cancer.org/cancer/basal-and-squamous-cell-skin-cancer/about/key-statistics.html#:∼:text=Death%20from%20basal%20and%20squamous,been%20dropping%20in%20recent%20years. Cameron, 2018, Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations, J Am Acad Derm, 80, 303, 10.1016/j.jaad.2018.03.060 Rogers, 2015, Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the us population, 2012, JAMA Dermatol, 151, 1081, 10.1001/jamadermatol.2015.1187 Lomas, 2012, A systematic review of worldwide incidence of nonmelanoma skin cancer, Br J Dermatol, 166, 1069, 10.1111/j.1365-2133.2012.10830.x National Comprehensive Cancer Network. “Basal cell skin cancer, NCCN Guidelines Version 2.2022.”NCCN Clinical Practice Guidelines in Oncology [Internet], 2022 Available from: https://www.nccn.org/professionals/physician_gls/pdf/nmsc.pdf (2022). National Comprehensive Cancer Network. “Squamous cell skin cancer, NCCN Guidelines Version 2.2022.”NCCN Clinical Practice Guidelines in Oncology [Internet], 2022 Available from: https://www. nccn.org/professionals/physician_gls/pdf/squamous. pdf(2022). Veness, 2012, Radiotherapy, vol. 2, 2291 McGregor, 2015, Superficial radiation therapy for the treatment of nonmelanoma skin cancers, J Clin Aesthet Dermatol, 8, 12 Cognetta, 2016, Practice and educational gaps in radiation therapy in dermatology, Dermatol Clin, 34, 319, 10.1016/j.det.2016.02.011 Yu, 2021, The treatment of non-melanoma skin cancer with image-guided superficial radiation therapy: an analysis of 2917 invasive and in situ keratinocytic carcinoma lesions, Oncology Therapy, 9, 153, 10.1007/s40487-021-00138-4 McClure, Erin M., et al. “Image guidance improves freedom from recurrence in superficial radiation therapy for non-melanoma skin cancer.” medRxiv (2022). Tomás-Velázquez, 2021, Risk factors and rate of recurrence after Mohs surgery in basal cell and squamous cell carcinomas: a nationwide prospective cohort (REGESMOHS, Spanish registry of Mohs surgery), Acta Derm Venereol, 101, adv00602, 10.2340/actadv.v101.544 Xiong, 2020, Outcomes in intermediate-risk squamous cell carcinomas treated with Mohs micrographic surgery compared with wide local excision, J Am Acad Dermatol, 82, 1195, 10.1016/j.jaad.2019.12.049 Lee, 2019, Recurrence rates of cutaneous squamous cell carcinoma of the head and neck after Mohs micrographic surgery vs. standard excision: a retrospective cohort study, Br J Dermatol, 181, 338, 10.1111/bjd.17188 Nehal, K., & Lee, E. (2023) Mohs surgery. In Miller, S.J & Corona, R (Eds.), UptoDate. Available from: https://www.uptodate.com/contents/mohs-surgery?search=mohs%20surgery&source=search_result&selectedTitle=1∼150&usage_type=default&display_rank=1#. Yu, 2021, Enhancing cosmesis while achieving high cure rates for early stage non-melanoma skin cancer in the outpatient dermatology clinic using a novel non-invasive modality, Clin Dermatology Res Ther, 4, 1 American Academy of Dermatology (n.d.). What is Mohs surgery? AAD. Retrieved January 26, 2023, from https://www.aad.org/public/diseases/skin-cancer/types/common/melanoma/mohs-surgery. Scott, 2017, A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study, Lancet Oncol, 18, 202, 10.1016/S1470-2045(16)30648-9 Scott, 2021, Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis, Lancet Oncol, 22, 1221, 10.1016/S1470-2045(21)00347-8