Image-guided adaptive radiotherapy improves acute toxicity during intensity-modulated radiation therapy for head and neck cancer

Beltran M, Ramos M, Rovira JJ et al (2012) Dose variations in tumor volumes and organs during IMRT for head-and-neck cancer. J Appl Clin Med Phys 13:3723–3727 Bhide S, Davies M, Burke K et al (2010) Weekly volume and dosimetric changes during chemoradiotherapy with intensity-modulated radiation therapy for head and neck cancer: a prospective observational study. Int J Radiat Oncol Biol Phys 76(5):1360–1368. https://doi.org/10.1016/j.ijrobp.2009.04.005 Huang H, Lu H, Feng G, Jiang H, Chen J, Cheng J, Pang Q, Lu Z, Gu J, Peng L, Deng S, Mo Y, Wu D, Wei Y (2015) Determining appropriate timing of adaptive radiation therapy for nasopharyngeal carcinoma during intensity-modulated radiation therapy. Radiat Oncol 10(1):192. https://doi.org/10.1186/s13014-015-0498-1 Barker JL, Garden AS, Ang KK et al (2004) Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system. Int J Radiat Oncol Biol Phys 59(4):960–970. https://doi.org/10.1016/j.ijrobp.2003.12.024 Woodford C, Yartesv S, Dar AR et al (2007) Adaptive radiotherapy planning on decreasing gross tumor volumes as seen on megavoltage computed tomography images. Int J Radiat Oncol Biol Phys 69(4):1316–1322. https://doi.org/10.1016/j.ijrobp.2007.07.2369 Chen AM, Farwell DG, Luu Q, Donald PJ, Perks J, Purdy JA (2011) Evaluation of the planning target volume in the treatment of head and neck cancer with intensity-modulated radiotherapy: what is the appropriate expansion margin in the setting of daily image guidance? Int J Radiat Oncol Biol Phys 81(4):943–949. https://doi.org/10.1016/j.ijrobp.2010.07.017 Hansen EK, Bucci MK, Quivey JM, Weinberg V, Xia P (2006) Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 64(2):355–362. https://doi.org/10.1016/j.ijrobp.2005.07.957 Lu J, Ma Y, Chen J, Wang L, Zhang G, Zhao M, Yin Y (2014) Assessment of anatomical and dosimetric changes by a deformable registration method during the course of intensity-modulated radiotherapy for nasopharyngeal carcinoma. J Radiat Res 55(1):97–104. https://doi.org/10.1093/jrr/rrt076 Lee N, Chuang C, Quivey JM, Phillips TL, Akazawa P, Verhey LJ, Xia P (2002) Skin toxicity due to intensity-modulated radiotherapy for head and neck carcinoma. Int J Radiat Oncol Biol Phys 53(3):630–637. https://doi.org/10.1016/S0360-3016(02)02756-6 Narayan S, Lehmann J, Coleman MA, Vaughan A, Yang CC, Enepekides D, Farwell G, Purdy JA, Laredo G, Nolan K, Pearson FS, Vijayakumar S (2008) Prospective evaluation to establish a dose response for clinical oral mucositis in patients undergoing head and neck conformal radiotherapy. Int J Radiat Oncol Biol Phys 72(3):756–762. https://doi.org/10.1016/j.ijrobp.2008.01.060 Rosenthal DI, Chambers MS, Fuller CD, Rebueno NCS, Garcia J, Kies MS, Morrison WH, Ang KK, Garden AS (2008) Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys 72(3):747–755. https://doi.org/10.1016/j.ijrobp.2008.01.012 Yang H, Hu W, Wang W, Chen P, Ding W, Luo W (2013) Replanning during intensity-modulated radiation therapy improved quality of life in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 85(1):e47–e54. https://doi.org/10.1016/j.ijrobp.2012.09.033 Schwartz DL, Garden AS, Thomas J, Chen Y, Zhang Y, Lewin J, Chambers MS, Dong L (2012) Adaptive radiotherapy for head-and-neck cancer: initial clinical results from a prospective trial. Int J Radiat Oncol Biol Phys 83(3):986–993. https://doi.org/10.1016/j.ijrobp.2011.08.017 Schwartz DL, Garden AS, Shah SJ, Chronowski G, Sejpal S, Rosenthal DI, Chen Y, Zhang Y, Zhang L, Wong PF, Garcia JA, Kian Ang K, Dong L (2013) Adaptive radiotherapy for head and neck cancer—dosimetric results from a prospective clinical trial. Radiother Oncol 106(1):80–84. https://doi.org/10.1016/j.radonc.2012.10.010 Chen AM, Daly ME, Cui J, Mathai M, Benedict S, Purdy JA (2014) Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning. Head Neck 36(11):1541–1546. https://doi.org/10.1002/hed.23477 Wang W, Yang H, Hu W, Shan G, Ding W, Yu C, Wang B, Wang X, Xu Q (2010) Clinical study of the necessity of replanning before the 25th fraction during the course of intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 77(2):617–621. https://doi.org/10.1016/j.ijrobp.2009.08.036 You SH, Kim SY, Lee CG et al (2012) Is there a clinical benefit to adaptive planning during tomotherapy in patients with head and neck cancer at risk for xerostomia? Am J Clin Oncol 35:262–266 Ahn P (2011) PH, Chen CC, Ahn AI, et al. adaptive planning in intensity-modulated radiation therapy for head and neck cancers: single-institution experience and clinical implications. Int J Radiat Oncol Biol Phys 80(3):677–685. https://doi.org/10.1016/j.ijrobp.2010.03.014 Moteabbed M, Sharp GC, Wang Y, Trofimov A, Efstathiou JA, Lu HM (2015) Validation of a deformable image registration technique for cone beam CT-based dose verification. Med Phys 42(1):196–205. https://doi.org/10.1118/1.4903292 Veiga C, McClelland J, Moinuddin S, Lourenço A, Ricketts K, Annkah J, Modat M, Ourselin S, D'Souza D, Royle G (2014) Toward adaptive radiotherapy for head and neck patients: feasibility study on using CT-to-CBCT deformable registration for “dose of the day” calculations. Med Phys 41(3):031703. https://doi.org/10.1118/1.4864240 Raghavan G, Kishan AU, Cao M, Chen AM (2016) Anatomic and dosimetric changes in patients with head and neck cancer treated with an integrated MRI-tri-Co teletherapy device. Br J Radiol 89(1067):20160624. https://doi.org/10.1259/bjr.20160624