Illustrating the potency of current Good Manufacturing Practice–compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols

Cytotherapy - Tập 20 - Trang 861-872 - 2018
Mahendra S. Rao1,2, Ying Pei2, Thelma Y. Garcia3, Shereen Chew3, Toshiharu Kasai4, Tomoko Hisai4, Hideki Taniguchi4, Takanori Takebe4,5, Deepak A. Lamba3, Xianmin Zeng1,2,3
1NxCell Inc., Novato, California, USA
2XCell Science Inc., Novato, California, USA
3Buck Institute for Research on Aging, Novato, California, USA
4Department of Regenerative Medicine, Yokohama City University, Yokohama, Japan
5Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA

Tài liệu tham khảo

Mandai, 2017, Autologous induced stem-cell-derived retinal cells for macular degeneration, NEJM, 376, 1038, 10.1056/NEJMoa1608368 Solomon, 2015, Banking on iPSC-is it doable and is it worthwhile, Stem Cell Rev Rep, 11, 1, 10.1007/s12015-014-9574-4 Borger, 2016, Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions, Mol Med, 22, 10.2119/molmed.2015.00235 Figueiredo, 2015, A future with less HLA: potential clinical applications of HLA-universal cells, Tissue Antigens, 85, 443, 10.1111/tan.12564 Torikai, 2013, Toward eliminating HLA class I expression to generate universal cells from allogeneic donors, Blood, 122, 1341, 10.1182/blood-2013-03-478255 Rao, 2016, Developing induced pluripotent stem cell-based therapy for the masses, Stem Cells Transl Med, 5, 129, 10.5966/sctm.2015-0184 Baghbaderani, 2015, cGMP-manufactured human induced pluripotent stem cells are available for pre-clinical and clinical applications, Stem Cell Reports, 5, 647, 10.1016/j.stemcr.2015.08.015 Swistowski, 2009, Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them, PLoS ONE, 4, e6233, 10.1371/journal.pone.0006233 Patsch, 2015, Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells, Nat Cell Biol, 17, 994, 10.1038/ncb3205 Swistowska, 2010, Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells, Stem Cells Dev, 19, 71, 10.1089/scd.2009.0107 Zeng, 2003, Stable expression of hrGFP by mouse embryonic stem cells: promoter activity in the undifferentiated state and during dopaminergic neural differentiation, Stem Cells, 21, 647, 10.1634/stemcells.21-6-647 Pei, 2015, A platform for rapid generation of single and multiplexed reporters in human iPSC lines, Sci Rep, 5, 9205, 10.1038/srep09205 Reid, 2004 Swistowski, 2010, Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions, Stem Cells, 28, 1893, 10.1002/stem.499 Liu, 2013, Optimizing dopaminergic differentiation of pluripotent stem cells for the manufacture of dopaminergic neurons for transplantation, Cytotherapy, 15, 999, 10.1016/j.jcyt.2013.03.006 Peng, 2014, Survival and engraftment of dopaminergic neurons manufactured by a Good Manufacturing Practice-compatible process, Cytotherapy, 16, 1305, 10.1016/j.jcyt.2014.06.002 Shaltouki, 2013, Efficient generation of astrocytes from human pluripotent stem cells in defined conditions, Stem Cells, 31, 941, 10.1002/stem.1334 Zhu, 2017, Immunosuppression via loss of IL2rγ enhances long-term functional integration of hESC-derived photoreceptors in the mouse retina, Cell Stem Cell, 20, 374, 10.1016/j.stem.2016.11.019 Takebe, 2013, Vascularized and functional human liver from an iPSC-derived organ bud transplant, Nature, 499, 481, 10.1038/nature12271 Baghbaderani, 2016, Detailed characterization of human induced pluripotent stem cells manufactured for therapeutic applications, Stem Cell Rev, 12, 394, 10.1007/s12015-016-9662-8