Kỹ thuật tái cấu trúc Fc IgG nhằm điều chỉnh các chức năng vận động của kháng thể

Protein & Cell - Tập 9 - Trang 63-73 - 2017
Xinhua Wang1, Mary Mathieu1, Randall J. Brezski1
1Genentech, Antibody Engineering, South San Francisco, USA

Tóm tắt

Các kháng thể đơn dòng điều trị là một trong những liệu pháp sinh học hiệu quả nhất tính đến thời điểm hiện tại. Một khía cạnh quan trọng của kháng thể là khả năng liên kết với kháng nguyên trong khi đồng thời thu hút các chức năng hiệu quả của hệ miễn dịch. Phần lớn các liệu pháp kháng thể đơn dòng tái tổ hợp đã được phê duyệt thuộc loại IgG1 người, có khả năng tương tác với cả thành phần dịch thể và tế bào của hệ miễn dịch. Khối lượng thông tin thu được về các kháng thể đã giúp các nhà nghiên cứu có khả năng thiết kế lại kháng thể ở mức phân tử nhằm điều chỉnh các chức năng hiệu quả. Bài viết này sẽ đánh giá các nỗ lực kỹ thuật kháng thể khác nhau nhằm cải thiện hiệu quả và độ an toàn so với thể loại IgG của con người. Hơn nữa, chúng tôi sẽ thảo luận về các cơ chế được đề xuất mà qua đó các phương pháp kỹ thuật dẫn đến những tương tác được sửa đổi với các thành phần miễn dịch và cung cấp các ví dụ về các nghiên cứu lâm sàng sử dụng kháng thể thế hệ tiếp theo.

Từ khóa

#kháng thể đơn dòng #IgG #hệ miễn dịch #tái cấu trúc #nghiên cứu lâm sàng

Tài liệu tham khảo

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