IgE-mediated mast cell responses are inhibited by thymol-mediated, activation-induced cell death in skin inflammation

Theoharides, 2007, Differential release of mast cell mediators and the pathogenesis of inflammation, Immunol Rev, 217, 65, 10.1111/j.1600-065X.2007.00519.x Bischoff, 2007, Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data, Nat Rev Immunol, 7, 93, 10.1038/nri2018 Tsai, 2011, Mast cells and immunoregulation/immunomodulation, Adv Exp Med Biol, 716, 186, 10.1007/978-1-4419-9533-9_11 Ekoff, 2011, Mast cell apoptosis and survival, Adv Exp Med Biol, 716, 47, 10.1007/978-1-4419-9533-9_4 Kay, 2001, Allergy and allergic diseases. Second of two parts, N Engl J Med, 344, 109, 10.1056/NEJM200101113440206 Kay, 2001, Allergy and allergic diseases. First of two parts, N Engl J Med, 344, 30, 10.1056/NEJM200101043440106 Luskova, 2004, Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases, Curr Pharm Des, 10, 1727, 10.2174/1381612043384538 Karra, 2009, Are we ready to downregulate mast cells?, Curr Opin Immunol, 21, 708, 10.1016/j.coi.2009.09.010 Kovarova, 2004, A molecular understanding of mast cell activation and the promise of anti-allergic therapeutics, Curr Med Chem, 11, 2083, 10.2174/0929867043364801 Alenius, 2002, Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation, J Allergy Clin Immunol, 109, 106, 10.1067/mai.2002.120553 Tanei, 2013, Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly, J Eur Acad Dermatol Venereol, 27, 952, 10.1111/j.1468-3083.2012.04612.x Navi, 2007, Mast cells and immunological skin diseases, Clin Rev Allergy Immunol, 33, 144, 10.1007/s12016-007-0029-4 Liu, 2011, IgE, Mast cells, and eosinophils in atopic dermatitis, Clin Rev Allergy Immunol, 41, 298, 10.1007/s12016-011-8252-4 Soter, 1989, Morphology of atopic eczema, Allergy, 44, 16, 10.1111/j.1398-9995.1989.tb02449.x Irani, 1989, Mast cells in atopic dermatitis, Allergy, 44, 31, 10.1111/j.1398-9995.1989.tb02452.x Gombert, 2005, CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation, J Immunol, 174, 5082, 10.4049/jimmunol.174.8.5082 Horsmanheimo, 1994, Mast cells are one major source of interleukin-4 in atopic dermatitis, Br J Dermatol, 131, 348, 10.1111/j.1365-2133.1994.tb08522.x Crocker, 1878, Thymol as a remedy in skin-diseases, BMJ, 1, 225, 10.1136/bmj.1.894.225 Baser, 2008, Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils, Curr Pharm Des, 14, 3106, 10.2174/138161208786404227 Basch, 2004, Thyme (Thymus vulgaris L.), thymol, J Herb Pharmacother, 4, 49, 10.1080/J157v04n01_07 Burt, 2004, Essential oils: their antibacterial properties and potential applications in foods—a review, Int J Food Microbiol, 94, 223, 10.1016/j.ijfoodmicro.2004.03.022 Shapiro, 1995, The action of thymol on oral bacteria, Oral Microbiol Immunol, 10, 241, 10.1111/j.1399-302X.1995.tb00149.x Guo, 2009, Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans, J Med Microbiol, 58, 1074, 10.1099/jmm.0.008052-0 Kim, 2004, Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship, Crit Rev Food Sci Nutr, 44, 253, 10.1080/10408690490464960 Archana, 2009, Thymol, a naturally occurring monocyclic dietary phenolic compound protects Chinese hamster lung fibroblasts from radiation-induced cytotoxicity, Mutat Res, 680, 70, 10.1016/j.mrgentox.2009.09.010 Xu, 2006, Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels, Nat Neurosci, 9, 628, 10.1038/nn1692 Lee, 2008, Thymol and related alkyl phenols activate the hTRPA1 channel, Br J Pharmacol, 153, 1739, 10.1038/bjp.2008.85 Moran, 2011, Transient receptor potential channels as therapeutic targets, Nat Rev Drug Discov, 10, 601, 10.1038/nrd3456 Hsu, 2011, Effect of thymol on Ca(2+) homeostasis and viability in human glioblastoma cells, Eur J Pharmacol, 670, 85, 10.1016/j.ejphar.2011.08.017 Shen, 2009, Thymol-evoked Ca+ mobilization and ion currents in pituitary GH3 cells, Nat Prod Commun, 4, 749 Chang, 2011, Effect of thymol on Ca2+ homeostasis and viability in MG63 human osteosarcoma cells, Pharmacology, 88, 201, 10.1159/000331864 Slamenova, 2007, DNA-protective effects of two components of essential plant oils carvacrol and thymol on mammalian cells cultured in vitro, Neoplasma, 54, 108 Horvathova, 2007, Comparative study of DNA-damaging and DNA-protective effects of selected components of essential plant oils in human leukemic cells K562, Neoplasma, 54, 478 Mahmud, 2009, Inhibitory effect of thymol on suicidal erythrocyte death, Cell Physiol Biochem, 24, 407, 10.1159/000257433 Xuan, 2010, Role of acidic sphingomyelinase in thymol-mediated dendritic cell death, Mol Nutr Food Res, 54, 1833, 10.1002/mnfr.200900577 Deb, 2011, Effect of thymol on peripheral blood mononuclear cell PBMC and acute promyelotic cancer cell line HL-60, Chem Biol Interact, 193, 97, 10.1016/j.cbi.2011.05.009 Stammati, 1999, Toxicity of selected plant volatiles in microbial and mammalian short-term assays, Food Chem Toxicol, 37, 813, 10.1016/S0278-6915(99)00075-7 Satooka, 2012, Effects of thymol on B16-F10 melanoma cells, J Agric Food Chem, 60, 2746, 10.1021/jf204525b Dong, 2006, Calcium in cell injury and death, Annu Rev Pathol, 1, 405, 10.1146/annurev.pathol.1.110304.100218 Inoue, 2008, Nitric oxide protects mast cells from activation-induced cell death: the role of the phosphatidylinositol-3 kinase-Akt-endothelial nitric oxide synthase pathway, J Leukoc Biol, 83, 1218, 10.1189/jlb.1007667 Soboloff, 2002, Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells, J Biol Chem, 277, 13812, 10.1074/jbc.M112129200 Ohtsu, 2001, Mice lacking histidine decarboxylase exhibit abnormal mast cells, FEBS Lett, 502, 53, 10.1016/S0014-5793(01)02663-1 Bensley, 1952, Pinacyanol erthrosinate as a stain for mast cells, Stain Technol, 27, 269, 10.3109/10520295209105090 Hsu, 2010, IL-33 is produced by mast cells and regulates IgE-dependent inflammation, PLoS One, 5, e11944, 10.1371/journal.pone.0011944 Salvatore, 2000, Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells, J Biol Chem, 275, 4429, 10.1074/jbc.275.6.4429 Ganeshan, 2009, Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model, J Allergy Clin Immunol, 123, 231, 10.1016/j.jaci.2008.10.011 Gong, 1994, A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry, Anal Biochem, 218, 314 Zhou, 2007, Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis, J Exp Med, 204, 2797, 10.1084/jem.20071391 Malaviya, 2002, Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells, J Immunol, 168, 421, 10.4049/jimmunol.168.1.421 Prasad, 2008, Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A, J Immunol, 181, 5024, 10.4049/jimmunol.181.7.5024 del Camino, 2010, TRPA1 contributes to cold hypersensitivity, J Neurosci, 30, 15165, 10.1523/JNEUROSCI.2580-10.2010 Ma, 2011, Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases?, Adv Exp Medicine Biol, 716, 62, 10.1007/978-1-4419-9533-9_5 Andres, 2008, Omalizumab for patients with severe and therapy-refractory atopic eczema?, Curr Allergy Asthma Rep, 8, 179, 10.1007/s11882-008-0029-3 Darsow, 2005, Position paper on diagnosis and treatment of atopic dermatitis, J Eur Acad Dermatol Venereol, 19, 286, 10.1111/j.1468-3083.2005.01249.x Hartmann, 1997, Fas (CD95, APO-1) antigen expression and function in murine mast cells, J Immunol, 159, 4006, 10.4049/jimmunol.159.8.4006 Berent-Maoz, 2006, Human mast cells undergo TRAIL-induced apoptosis, J Immunol, 176, 2272, 10.4049/jimmunol.176.4.2272 Bachelet, 2005, The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells, J Immunol, 175, 7989, 10.4049/jimmunol.175.12.7989 Ma, 2010, Pimecrolimus induces apoptosis of mast cells in a murine model of cutaneous mastocytosis, Int Arch Allergy Immunol, 153, 413, 10.1159/000316353 Karlberg, 2010, The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: potential for therapeutics, J Immunol, 185, 2555, 10.4049/jimmunol.0903656 Juurikivi, 2005, Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis, Ann Rheum Dis, 64, 1126, 10.1136/ard.2004.029835 Brenner, 2008, Concepts of activated T cell death, Crit Rev Oncol Hematol, 66, 52, 10.1016/j.critrevonc.2008.01.002 Suzuki, 2010, Endothelial nitric oxide synthase is essential for nitric oxide generation, L-type Ca2+ channel activation and survival in RBL-2H3 mast cells, Biochim Biophys Acta, 1803, 372, 10.1016/j.bbamcr.2009.11.003 Inoue, 2009, SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways, Mol Immunol, 47, 222, 10.1016/j.molimm.2009.09.033 Paller, 2012, Treatment strategies for atopic dermatitis: optimizing the available therapeutic options, Semin Cutan Med Surg, 31, S10, 10.1016/j.sder.2012.07.004 Vigo, 2006, Efficacy of anti-IgE therapy in patients with atopic dermatitis, J Am Acad Dermatol, 55, 168, 10.1016/j.jaad.2005.12.045