Idiopathic granulomatous mastitis—our experience

Springer Science and Business Media LLC - Tập 51 Số 1 - 2020
Pamulapati Manogna1, Bhawna Dev2, Leena Dennis Joseph2, Ramya Ramakrishnan2
1Sai Nilayam, Opposite Tulasi Enclave, Ramanna Pet, 1st line, Guntur-7, Andhra Pradesh, 522007, India
2Sri Ramachandra Institute of Higher Education & Research (SRIHER), Porur, Chennai, India

Tóm tắt

Abstract Background Idiopathic granulomatous mastitis (IGM) is a rare benign chronic inflammatory condition of the breast and is most commonly seen in women of childbearing age. The etiology is uncertain, and an autoimmune association has been suggested with the diagnosis usually made by exclusion. The clinical and radiological features often mimic that of breast cancer and hence confirmed early diagnosis is required to avoid misdiagnosis and unnecessary delay in the treatment. Results The most common clinical presentation of granulomatous mastitis is unilateral palpable breast lump with or without associated pain. The typical ultrasound finding is an ill-defined, irregular heterogeneous, predominantly hypoechoic lesion with multiple tentacles. Histologic features show a well-defined non-necrotizing epitheloid granulomas along with Langhans type giant cells. Conclusion Imaging features mimic that of breast cancer, and final diagnosis of granulomatous mastitis always requires specific pathologic findings while excluding other causes.

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Tài liệu tham khảo

Kessler E, Wolloch Y (1972) Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol 58(6):642–646 [Medline]

Gautier N, Lalonde L, Tran-Thanh D et al (2013) Chronic granulomatous mastitis: imaging, pathology and management. Eur J Radiol 82(4):e165–e175

Al-Khaffaf B, Knox F, Bundred NJ (2008) Idiopathic granulomatous mastitis: a 25-year experience. J Am Coll Surg 206(2):269–273

Going JJ, Anderson TJ, Wilkinson S, Chetty U (1987) Granulomatous lobular mastitis. J Clin Pathol 40:535–540

Cserni G, Szajki K (1999) Granulomatous lobular mastitis following drug-induced galactorrhea and blunt trauma. Breast J 5(6):398–403 [PubMed]

DeHertogh DA, Rossof AH, Harris AA, Economou SG (1980) Prednisone management of granulomatous mastitis. N Engl J Med 303:799–800

Fletcher A, Magrath IM, Riddell RH, Talbot IC (1982) Granulomatous mastitis: a report of seven cases. J Clin Pathol 35:941–945

Hovanessian Larsen LJ, Peyvandi B, Klipfel N, Grant E, Iyengar G (2009) Granulomatous lobular mastitis: imaging, diagnosis, and treatment. Am J Roentgenol 193(2):574–581

Fazzio RT, Shah SS, Sandhu NP, Glazebrook KN (2016) Idiopathic granulomatous mastitis: imaging update and review. Insights Imaging 7(4):531–539. https://doi.org/10.1007/s13244-016-0499-0

Lee JH, Oh KK, Kim EK, Kwack KS, Jung WH, Lee HK (2006) Radiologic and clinical features of idiopathic granulomatous lobular mastitis mimicking advanced breast cancer. Yonsei Med J 47:78–84

Aghajanzadeh M, Hassanzadeh R, Alizadeh Sefat S et al (2015) Granulomatous mastitis: presentations, diagnosis, treatment and outcome in 206 patients from the north of Iran. Breast 24(4):456–460

Han BK, Choe YH, Park JM et al (1999) Granulomatous mastitis: mammographic and sonographic appearances. AJR 173:317–320

Yilmaz E, Lebe B, Usal C, Balci P (2001) Mammographic and sonographic findings in the diagnosis of idiopathic granulomatous mastitis. Eur Radiol 11:2236–2240

Al-Khawari HA, Al-Manfouhi HA, Madda JP, Kovacs A, Sheikh M, Roberts O (2011) Radiologic features of granulomatous mastitis. Breast J 17(6):645–650

Memis A, Bilgen I, Ustun EE, Ozdemir N, Erhan Y, Kapkac M (2002) Granulomatous mastitis; imaging findings with histopathologic correlation. Clin Radiol 57:1001–1006

Oztekin PS, Durhan G, Nercis Kosar P, Erel S, Hucumenoglu S (2016) Imaging findings in patients with granulomatous mastitis. Iran J Radiol 13(3):e33900. https://doi.org/10.5812/iranjradiol.33900

Imoto S, Kitaya T, Kodama T, Hasabe T, Mukai K (1997) Idiopathic granulomatous mastitis: case report and review of the literature. Jpn J Clin Oncol 27:274–277

Pluguez-Turull CW, Nanyes JE, Quintero CJ, Alizai H, Mais DD, Kist KA, Dornbluth NC (2018) Idiopathic granulomatous mastitis; manifestations at multimodality imaging and pitfalls. RadioGraphics 38(2):330–356

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Tập 51 Số 1

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