Identifying orphan G protein coupled receptors in drug discovery

Drug Discovery Today: Technologies - Tập 1 - Trang 61-68 - 2004
John Dunlop1, Richard M Eglen2
1Neuroscience Discovery Research, Wyeth Research, CN-8000, Princeton, NJ 08543, USA
2DiscoveRx Corporation, 42501 Albrae St. Fremont, CA 94538, USA

Tài liệu tham khảo

Thomsen, 2004, Developing functional GPCR screens, Curr. Drug Discovery Dev., 6, 13 Vassilatis, 2003, The G protein coupled receptor repertoires of human and mouse, Proc. Nat. Acad. Sci. USA, 100, 4903, 10.1073/pnas.0230374100 Lee, 2003, Continued discovery of ligands for G protein-coupled receptors, Life Sci., 74, 293, 10.1016/j.lfs.2003.09.016 Wise, 2002, Target validation of G protein coupled receptors, Drug Discovery Today, 7, 235, 10.1016/S1359-6446(01)02131-6 Wise, 2004, The identification of ligands at orphan G-protein coupled receptors, Ann. Rev. Pharmacol. Toxicol., 44, 43, 10.1146/annurev.pharmtox.44.101802.121419 Milligan, 2002, Strategies to identify ligands for orphan G-protein coupled receptors, Biochem. Soc. Trans., 30, 789, 10.1042/bst0300789 Ballesteros, 2001, G protein coupled receptor drug discovery: implications from the crystal structure of rhodopsin, Curr. Drug Discovery Dev., 4, 561 Milligan, 1999, Exploring the dynamics of regulation of G protein coupled receptors using green fluorescent protein, Br. J. Pharmacol., 128, 501, 10.1038/sj.bjp.0702824 Jenkins, 2004, Targeting GPCRs in silico, Curr. Drug Discovery March, 23 Guo, 2003, Privileged structure based combinatorial libraries targeting G protein coupled receptors, Assays Drug Dev. Tech., 1, 579, 10.1089/154065803322302835 Klabunde, 2002, Drug design strategies for targeting G-protein coupled receptors, Chem. BioChem., 3, 928 Chalmers, 2002, The use of constitutively active GPCRs in drug discovery and functional genomics, Nat. Rev. Drug Discovery, 1, 599, 10.1038/nrd872 Jayawickreme, C.K. et al. (2000) Melanophore recombinant receptor systems. In Handbook of Experimental Pharmacology (Pharmacology of Functional. Biochemical and Recombinant Receptor Systems) (Vol. 148), pp. 415–439 Szekeres, 2002, Functional assays for identifying ligands at orphan G protein coupled receptors, Recept. Channels, 8, 297, 10.1080/10606820214642 Bresnick, 2003, Identification of signal transduction pathways used by orphan G protein coupled receptors, Assay Drug Dev., 1, 239, 10.1089/15406580360545053 Milligan, 2003, High-content assays for ligand regulation of G-protein-coupled receptors, Drug Discovery Today, 8, 579, 10.1016/S1359-6446(03)02738-7 Ferguson, 2004, Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation, Methods Mol. Biol., 237, 121 Adie, 2003, CypHer 5: a generic approach for measuring the activation and trafficking of G protein coupled receptors, Assay Drug Dev., 1, 251, 10.1089/15406580360545062 Howard, 2001, Orphan G-protein-coupled receptors and natural ligand discovery, Trends Pharmacol. Sci., 22, 132, 10.1016/S0165-6147(00)01636-9 Lee, 2002, Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets, Expert Opin. Ther. Targets, 6, 185, 10.1517/14728222.6.2.185 Nilsson, 2003, Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids, Biochem. Biophys. Res. Commun., 303, 1047, 10.1016/S0006-291X(03)00488-1 Meder, 2003, Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23, FEBS Lett., 555, 495, 10.1016/S0014-5793(03)01312-7 Lammerich, 2003, Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3, Br. J. Pharmacol., 138, 1431, 10.1038/sj.bjp.0705177