Identifying orphan G protein coupled receptors in drug discovery
Tài liệu tham khảo
Thomsen, 2004, Developing functional GPCR screens, Curr. Drug Discovery Dev., 6, 13
Vassilatis, 2003, The G protein coupled receptor repertoires of human and mouse, Proc. Nat. Acad. Sci. USA, 100, 4903, 10.1073/pnas.0230374100
Lee, 2003, Continued discovery of ligands for G protein-coupled receptors, Life Sci., 74, 293, 10.1016/j.lfs.2003.09.016
Wise, 2002, Target validation of G protein coupled receptors, Drug Discovery Today, 7, 235, 10.1016/S1359-6446(01)02131-6
Wise, 2004, The identification of ligands at orphan G-protein coupled receptors, Ann. Rev. Pharmacol. Toxicol., 44, 43, 10.1146/annurev.pharmtox.44.101802.121419
Milligan, 2002, Strategies to identify ligands for orphan G-protein coupled receptors, Biochem. Soc. Trans., 30, 789, 10.1042/bst0300789
Ballesteros, 2001, G protein coupled receptor drug discovery: implications from the crystal structure of rhodopsin, Curr. Drug Discovery Dev., 4, 561
Milligan, 1999, Exploring the dynamics of regulation of G protein coupled receptors using green fluorescent protein, Br. J. Pharmacol., 128, 501, 10.1038/sj.bjp.0702824
Jenkins, 2004, Targeting GPCRs in silico, Curr. Drug Discovery March, 23
Guo, 2003, Privileged structure based combinatorial libraries targeting G protein coupled receptors, Assays Drug Dev. Tech., 1, 579, 10.1089/154065803322302835
Klabunde, 2002, Drug design strategies for targeting G-protein coupled receptors, Chem. BioChem., 3, 928
Chalmers, 2002, The use of constitutively active GPCRs in drug discovery and functional genomics, Nat. Rev. Drug Discovery, 1, 599, 10.1038/nrd872
Jayawickreme, C.K. et al. (2000) Melanophore recombinant receptor systems. In Handbook of Experimental Pharmacology (Pharmacology of Functional. Biochemical and Recombinant Receptor Systems) (Vol. 148), pp. 415–439
Szekeres, 2002, Functional assays for identifying ligands at orphan G protein coupled receptors, Recept. Channels, 8, 297, 10.1080/10606820214642
Bresnick, 2003, Identification of signal transduction pathways used by orphan G protein coupled receptors, Assay Drug Dev., 1, 239, 10.1089/15406580360545053
Milligan, 2003, High-content assays for ligand regulation of G-protein-coupled receptors, Drug Discovery Today, 8, 579, 10.1016/S1359-6446(03)02738-7
Ferguson, 2004, Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation, Methods Mol. Biol., 237, 121
Adie, 2003, CypHer 5: a generic approach for measuring the activation and trafficking of G protein coupled receptors, Assay Drug Dev., 1, 251, 10.1089/15406580360545062
Howard, 2001, Orphan G-protein-coupled receptors and natural ligand discovery, Trends Pharmacol. Sci., 22, 132, 10.1016/S0165-6147(00)01636-9
Lee, 2002, Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets, Expert Opin. Ther. Targets, 6, 185, 10.1517/14728222.6.2.185
Nilsson, 2003, Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids, Biochem. Biophys. Res. Commun., 303, 1047, 10.1016/S0006-291X(03)00488-1
Meder, 2003, Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23, FEBS Lett., 555, 495, 10.1016/S0014-5793(03)01312-7
Lammerich, 2003, Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3, Br. J. Pharmacol., 138, 1431, 10.1038/sj.bjp.0705177