Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Xác định rối loạn trầm cảm chính có liên quan đến rối loạn giấc ngủ qua độ đồng nhất vùng fMRI trong trạng thái nghỉ
Tóm tắt
Các bất thường trong tính đồng nhất vùng (ReHo) đã được ghi nhận ở những bệnh nhân mắc rối loạn trầm cảm chính (MDD) và các rối loạn giấc ngủ (SD). Nghiên cứu này nhằm phân tích sự thay đổi trong ReHo ở bệnh nhân MDD kèm theo SD, và để phát triển các dấu ấn sinh học chẩn đoán tiềm năng cho việc phát hiện các tình trạng liên quan đến giấc ngủ ở bệnh nhân MDD. Những bệnh nhân MDD và các đối chứng khỏe mạnh đã thực hiện quét hình ảnh cộng hưởng từ chức năng trong trạng thái nghỉ. Mức độ nghiêm trọng của SD được định lượng bằng thang đo Hamilton 17 mục cho trầm cảm. Sau khi thu thập dữ liệu hình ảnh, phân tích ReHo đã được thực hiện, và phương pháp máy vector hỗ trợ (SVM) đã được sử dụng để đánh giá khả năng của ReHo trong việc phân biệt các bệnh nhân MDD kèm theo SD. So với những bệnh nhân MDD không có SD, những bệnh nhân MDD có SD cho thấy giá trị ReHo tăng lên ở vỏ não cingulate sau bên phải (PCC)/precuneus, vỏ não cingulate giữa bên phải, hồi sau trung tâm bên trái (postCG) và hồi thái dương dưới bên phải (ITG). Hơn nữa, các giá trị ReHo ở PCC/precuneus bên phải và ITG cho thấy mối tương quan tích cực với các triệu chứng lâm sàng ở tất cả bệnh nhân. Kết quả phân loại SVM cho thấy sự kết hợp của các bất thường ReHo ở postCG bên trái và ITG bên phải đạt được độ chính xác tổng thể là 84,21%, độ nhạy là 81,82% và độ đặc hiệu là 87,50% trong việc xác định các bệnh nhân MDD kèm theo SD và không kèm theo SD. Chúng tôi đã xác định các mẫu ReHo bị rối loạn ở bệnh nhân MDD có SD và trình bày một dấu ấn sinh học chẩn đoán tiềm năng dựa trên hình ảnh thần kinh cho những bệnh nhân này.
Từ khóa
#rối loạn trầm cảm chính #rối loạn giấc ngủ #đồng nhất vùng #hình ảnh cộng hưởng từ chức năng #dấu ấn sinh học chẩn đoánTài liệu tham khảo
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