Identifying absorbable bioactive constituents of Yupingfeng Powder acting on COVID-19 through integration of UPLC-Q/TOF-MS and network pharmacology analysis

Arrell, 2009, ATP-sensitive K+channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility, Journal of Proteome Research, 8, 4823, 10.1021/pr900561g Chen, 2020, Thoughts on prevention and treatment of coronavirus disease 2019 (COVID-19) by traditional Chinese medicine, Chinese Traditional and Herbal Drugs, 51, 1106 Du, 2020, Traditional Chinese Medicine: An effective treatment for 2019 novel coronavirus pneumonia (NCP), Chinese Journal of Natural Medicines, 18, 206, 10.1016/S1875-5364(20)30022-4 Gfeller, 2013, Shaping the interaction landscape of bioactive molecules, Bioinformatics, 29, 3073, 10.1093/bioinformatics/btt540 Han, 2016, Optimization of supercritical fluid extraction and rapid resolution LC-MS/ESI identification of chromones from Saposhnikoviae Radix through orthogonal array design, Chinese Herbal Medicines, 8, 314, 10.1016/S1674-6384(16)60057-6 Huang, 2020, Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19), Pharmacological Research, 158, 104939, 10.1016/j.phrs.2020.104939 Jia, 2017, Using UPLC-MS/MS for characterization of active components in extracts of Yupingfeng and application to a comparative pharmacokinetic study in rat plasma after oral administration, Molecules, 22, 810, 10.3390/molecules22050810 Li, 2017, Wogonin attenuates inflammation by activating PPAR-gamma in alcoholic liver disease, International Immunopharmacology, 50, 95, 10.1016/j.intimp.2017.06.013 Li, 2017, Research review on the pharmacological effects of astragaloside IV, Fundamental & Clinical Pharmacology, 31, 17, 10.1111/fcp.12232 Li, 2014, Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats, Phytomedicine, 22, 111, 10.1016/j.phymed.2014.10.011 Li, 2020, Network pharmacology based investigation into the bioactive compounds and molecular mechanisms of Schisandrae Chinensis Fructus against drug-induced liver injury, Bioorganic Chemistry, 96, 103553, 10.1016/j.bioorg.2019.103553 Li, 2012, Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats, Biomedical Chromatography, 26, 1234, 10.1002/bmc.2684 Li, 2017, Yupingfeng Powder relieves the immune suppression induced by dexamethasone in mice, Journal of Ethnopharmacology, 200, 117, 10.1016/j.jep.2017.01.054 Liu, 2010, PharmMapper server: A web server for potential drug target identification using pharmacophore mapping approach, Nucleic Acids Research, 38, W609, 10.1093/nar/gkq300 Liu, 2017, Yupingfeng San inhibits NLRP3 inflammasome to attenuate the inflammatory response in asthma mice, Frontiers in Pharmacology, 8, 944, 10.3389/fphar.2017.00944 Luo, 2020, Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? A review of historical classics, research evidence and current prevention programs, Chinese Journal of Integrative Medicine, 26, 243, 10.1007/s11655-020-3192-6 Ma, 2018, Effects of YuPingFeng granules on acute exacerbations of COPD: A randomized, placebo-controlled study, International Journal of Chronic Obstructive Pulmonary Disease, 13, 3107, 10.2147/COPD.S170555 Nikles, 2017, Metabolic profiling of the traditional Chinese medicine formulation Yu Ping Feng San for the identification of constituents relevant for effects on expression of TNF-alpha, IFN-gamma, IL-1beta and IL-4 in U937 cells, Journal of Pharmaceutical and Biomedical Analysis, 145, 219, 10.1016/j.jpba.2017.03.049 Oh, 2014, Anti-stress effect of astragaloside IV in immobilized mice, Journal of Ethnopharmacology, 153, 928, 10.1016/j.jep.2014.03.068 Ren, 2013, Pharmacological effects of Astragaloside IV: A literature review, Journal of Traditional Chinese Medicine, 33, 413, 10.1016/S0254-6272(13)60189-2 Robinson, 2020, The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19, Med, 1, 90, 10.1016/j.medj.2020.11.005 Ru, 2014, TCMSP: A database of systems pharmacology for drug discovery from herbal medicines, Journal of Cheminformatics, 6, 13, 10.1186/1758-2946-6-13 Shen, 2019, Integrating network pharmacology and bioinformatics analysis to explore the mechanism of Yupingfengsan in treating lung adenocarcinoma, European Journal of Integrative Medicine, 100967, 10.1016/j.eujim.2019.100967 Shi, 2015, Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC-MS/MS, Journal of Ethnopharmacology, 169, 183, 10.1016/j.jep.2015.04.019 Song, 2016, Adjuvant treatment with Yupingfeng Formula for recurrent respiratory tract infections in children: A Meta-analysis of randomized controlled trials, Phytotherapy Research, 30, 1095, 10.1002/ptr.5628 Sun, 2015, Immune-enhancing activity of polysaccharides isolated from Atractylodis macrocephalae Koidz, Carbohydrate Polymers, 126, 91, 10.1016/j.carbpol.2015.03.034 Von Mering, 2003, STRING: A database of predicted functional associations between proteins, Nucleic Acids Research, 31, 258, 10.1093/nar/gkg034 Wang, 2017, Mediating macrophage immunity with wogonin in mice with vascular inflammation, Molecular Medicine Reports, 16, 8434, 10.3892/mmr.2017.7611 Wang, 2020, Diagnosis and treatment of novel coronavirus pneumonia based on the theory of traditional Chinese medicine, Journal of Integrative Medicine, 18, 275, 10.1016/j.joim.2020.04.001 Wang, 2016, Enhancing the enrichment of pharmacophore-based target prediction for the polypharmacological profiles of drugs, Journal of Chemical Information and Modeling, 56, 1175, 10.1021/acs.jcim.5b00690 Wang, 2017, PharmMapper 2017 update: A web server for potential drug target identification with a comprehensive target pharmacophore database, Nucleic Acids Research, 45, W356, 10.1093/nar/gkx374 Wang, 2016, Yupingfeng Pulvis regulates the balance of T cell subsets in asthma mice, Evidence-based Complementary and Alternative Medicine, 2016, 1 Wu, 2019, Anticoagulant effect of wogonin against tissue factor expression, European Journal of Pharmacology, 859, 172517, 10.1016/j.ejphar.2019.172517 Xu, 2020, Traditional Chinese medicine treatment of COVID-19, Complementary Therapies in Clinical Practice, 39, 1, 10.1016/j.ctcp.2020.101165 Yan, 2010, Prevention of hospitalacquired pneumonia with Yupingfeng Powder in patients with acute cerebral vascular diseases: A randomized controlled trial, Zhong Xi Yi Jie He Xue Bao, 8, 25, 10.3736/jcim20100105 Yang, 2017, Feeble antipyretic, analgesic, and anti-inflammatory activities were found with regular dose 4'-O-β-D-glucosyl-5-O-methylvisamminol, One of the conventional marker compounds for quality evaluation of Radix Saposhnikoviae, Pharmacognosy magazine, 13, 168 Yang, 2020, Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): A review and perspective, International Journal of Biological Sciences, 16, 1708, 10.7150/ijbs.45538 Ye, 2020, Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia, Phytomedicine, 85, 153401, 10.1016/j.phymed.2020.153401 Yin, 2019, Yupingfeng polysaccharides enhances growth performance in Qingyuan partridge chicken by up-regulating the mRNA expression of SGLT1, GLUT2 and GLUT5, Veterinary Medicine and Science, 5, 451, 10.1002/vms3.167 You, 2020, Therapeutic strategy of traditional Chinese medicine for COVID-19, Drug Evaluation Research, 43, 613 Zhai, 2020, Traditional Chinese patent medicine Zhixiong Capsule (ZXC) alleviated formed atherosclerotic plaque in rat thoracic artery and the mechanism investigation including blood-dissolved-component-based network pharmacology analysis and biochemical validation, Journal of Ethnopharmacology, 254, 112523, 10.1016/j.jep.2019.112523 Zhang, 2020, The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence, Pharmacological Research, 157, 1 Zhao, 2016, The immune adjuvant response of polysaccharides from Atractylodis macrocephalae Koidz in chickens vaccinated against Newcastle disease (ND), Carbohydrate Polymers, 141, 190, 10.1016/j.carbpol.2016.01.013 Zhou, 2020, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study, The Lancet, 395, 1054, 10.1016/S0140-6736(20)30566-3 Zuo, 2018, A network pharmacology-based approach to analyse potential targets of traditional herbal formulas: An example of Yu Ping Feng decoction, Scientific Reports, 8, 11418, 10.1038/s41598-018-29764-1