Identification of novel α7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods

Bertrand, 1993, Proc. Natl. Acad. Sci. U.S.A., 90, 6971, 10.1073/pnas.90.15.6971 Seguela, 1993, J. Neurosci., 13, 596, 10.1523/JNEUROSCI.13-02-00596.1993 Alkondon, 1997, Eur. J. Neurosci., 9, 2734, 10.1111/j.1460-9568.1997.tb01702.x Zarei, 1999, Neuroscience, 88, 755, 10.1016/S0306-4522(98)00246-2 Frazier, 1998, J. Neurosci., 18, 8228, 10.1523/JNEUROSCI.18-20-08228.1998 Minana, 1998, Neuropharmacology, 37, 847, 10.1016/S0028-3908(98)00074-4 Albuquerque, 1998, Toxicol. Lett., 102–103, 211, 10.1016/S0378-4274(98)00309-9 Neubauer, 1998, Neurology, 51, 1608, 10.1212/WNL.51.6.1608 Stevens, 1998, Psycopharmacology, 136, 320, 10.1007/s002130050573 Adler, 1998, Schizophrenia Bull., 24, 189, 10.1093/oxfordjournals.schbul.a033320 Martin, 2004, Psycopharmacology, 174, 54, 10.1007/s00213-003-1750-1 Briggs, 1998, Neuropharmacology, 37, 1095, 10.1016/S0028-3908(98)00110-5 Lightfoot, 2008, Prog. Med. Chem., 46, 131, 10.1016/S0079-6468(07)00003-3 Pavlov, 2006, Biochem. Soc. Trans., 34, 1037, 10.1042/BST0341037 Breining, 2005, Ann. Rep. Med. Chem., 40, 3, 10.1016/S0065-7743(05)40001-9 Leonik, 2007, Bioorg. Med. Chem. Lett., 17, 1520, 10.1016/j.bmcl.2007.01.003 Carbonnelle, 2003, Eur. J. Pharmacol., 471, 85, 10.1016/S0014-2999(03)01817-X Virginio, 2002, Eur. J. Pharmacol., 445, 153, 10.1016/S0014-2999(02)01750-8 Catalyst 4.10, Accelrys Inc. http://accelrys.com. ROCS 2.0, OpenEye Scientific Software Inc. http://www.eyesopen.com/products/applications/rocs.html. multi_smarts_filter, Daylight 4.71 Daylight Inc. Pozzan, 2001, 224 Hamming, 1950, Bell Syst. Tech. J., 26, 147, 10.1002/j.1538-7305.1950.tb00463.x Ward, 1963, J. Am. Stat. Assoc., 58, 236, 10.1080/01621459.1963.10500845