Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach

Neurobiology of Disease - Tập 22 Số 1 - Trang 76-87 - 2006
Rukhsana Sultana1,2,3, H. Fai Poon1,2,3, Jian Cai4, William M. Pierce4, Michael L. Merchant5, Jon B. Klein5, William R. Markesbery6,3, D. Allan Butterfield1,2,3
1Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506 USA
2Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
3Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA
4Department of Pharmacology, University of Louisville, School of Medicine and VAMC, Louisville, KY 40202, USA
5Core Proteomics Laboratory, University of Louisville, Louisville, KY 40208, USA
6Department of Neurology and Pathology, University of Kentucky, Lexington, KY 40536, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aksenov, 1999, The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease, Neurochem. Res., 24, 767, 10.1023/A:1020783614031

Aksenova, 1999, Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders, Dementia Geriatr. Cognit. Disord., 10, 158, 10.1159/000017098

Aulak, 2004, Dynamics of protein nitration in cells and mitochondria, Am. J. Physiol.: Heart Circ. Physiol., 286, H30, 10.1152/ajpheart.00743.2003

Ball, 1977, Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia, a quantitative study, Acta Neuropathol. (Berl.), 37, 111, 10.1007/BF00692056

Beckman, 1996, Oxidative damage and tyrosine nitration from peroxynitrite, Chem. Res. Toxicol., 9, 836, 10.1021/tx9501445

Bosetti, 2002, Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease, Neurobiol. Aging, 23, 371, 10.1016/S0197-4580(01)00314-1

Boyd-Kimball, 2005, Proteomic identification of proteins specifically oxidized by intracerebral injection of Ab(1–42) into rat brain: implications for Alzheimer's disease, Neuroscience, 132, 313, 10.1016/j.neuroscience.2004.12.022

Busciglio, 2002, Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome, Neuron, 33, 677, 10.1016/S0896-6273(02)00604-9

Butterfield, 2001, Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide, Trends Mol. Med., 7, 548, 10.1016/S1471-4914(01)02173-6

Butterfield, 2002, Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death, Neurobiol. Aging, 23, 655, 10.1016/S0197-4580(01)00340-2

Butterfield, 2002, Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists, J. Alzheimer's Dis., 4, 193, 10.3233/JAD-2002-4309

Castegna, 2002, Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1, Free Radical Biol. Med., 33, 562, 10.1016/S0891-5849(02)00914-0

Castegna, 2002, Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain: Part II. Dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71, J. Neurochem., 82, 1524, 10.1046/j.1471-4159.2002.01103.x

Castegna, 2003, Proteomic identification of nitrated proteins in Alzheimer's disease brain, J. Neurochem., 85, 1394, 10.1046/j.1471-4159.2003.01786.x

Choi, 2004, Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases, J. Biol. Chem., 279, 13256, 10.1074/jbc.M314124200

Cookson, 1999, Oxidative stress and motor neurone disease, Brain Pathol., 9, 165, 10.1111/j.1750-3639.1999.tb00217.x

Csordas, 2003, Plasticity of mitochondrial calcium signaling, J. Biol. Chem., 278, 42273, 10.1074/jbc.M305248200

Dreyer, 2004, Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity, J. Neurosci., 24, 10454, 10.1523/JNEUROSCI.2265-04.2004

Du, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8

Erecinska, 1989, ATP and brain function, J. Cereb. Blood Flow Metab., 9, 2, 10.1038/jcbfm.1989.2

Geddes, 1996, Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease, Mol. Chem. Neuropathol., 28, 65, 10.1007/BF02815206

Gervais, 1999, Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation, Cell, 97, 395, 10.1016/S0092-8674(00)80748-5

Good, 1998, Protein nitration in Parkinson's disease, J. Neuropathol. Exp. Neurol., 57, 338, 10.1097/00005072-199804000-00006

Gow, 1996, Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation, FEBS Lett., 385, 63, 10.1016/0014-5793(96)00347-X

Hall, 1995, Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-alpha-phenylnitrone and difluoromethylornithine, Neuroscience, 69, 591, 10.1016/0306-4522(95)00289-U

Hall, 1995, Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes, Neuroscience, 64, 81, 10.1016/0306-4522(94)00385-I

Hall, 2004, Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury, J. Neurotrauma, 21, 9, 10.1089/089771504772695904

Halliwell, 1997, What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?, FEBS Lett., 411, 157, 10.1016/S0014-5793(97)00469-9

Hensley, 1998, Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation, J. Neurosci., 18, 8126, 10.1523/JNEUROSCI.18-20-08126.1998

Hirai, 2001, Mitochondrial abnormalities in Alzheimer's disease, J. Neurosci., 21, 3017, 10.1523/JNEUROSCI.21-09-03017.2001

Hoyer, 2004, Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications, Adv. Exp. Med. Biol., 541, 135, 10.1007/978-1-4419-8969-7_8

Ivins, 1999, Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8, Neurobiol. Dis., 6, 440, 10.1006/nbdi.1999.0268

Iwangoff, 1980, Glycolytic enzymes from human autoptic brain cortex: normal aged and demented cases, Mech. Ageing Dev., 14, 203, 10.1016/0047-6374(80)90120-7

Jonas, 2003, Modulation of synaptic transmission by the BCL-2 family protein BCL-xL, J. Neurosci., 23, 8423, 10.1523/JNEUROSCI.23-23-08423.2003

Jones, 1993, Entorhinal–hippocampal connections: a speculative view of their function, Trends Neurosci., 16, 58, 10.1016/0166-2236(93)90018-H

Junge, 1997, ATP synthase: an electrochemical transducer with rotatory mechanics, Trends Biochem Sci., 22, 420, 10.1016/S0968-0004(97)01129-8

Keil, 2004, Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis, J. Biol. Chem., 279, 50310, 10.1074/jbc.M405600200

Koeck, 2004, Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria, J. Biol. Chem., 279, 27257, 10.1074/jbc.M401586200

Koppal, 1999, Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease, J. Neurochem., 72, 310, 10.1046/j.1471-4159.1999.0720310.x

Korolainen, 2002, Proteomic analysis of protein oxidation in Alzheimer's disease brain, Electrophoresis, 23, 3428, 10.1002/1522-2683(200210)23:19<3428::AID-ELPS3428>3.0.CO;2-5

Lafon-Cazal, 1993, Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells, Neuropharmacology, 32, 1259, 10.1016/0028-3908(93)90020-4

Lauderback, 2001, The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1–42, J. Neurochem., 78, 413, 10.1046/j.1471-4159.2001.00451.x

Liu, 1996, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9

Lorenzo, 1999, Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death, Cell Death Differ., 6, 516, 10.1038/sj.cdd.4400527

Lovell, 2001, Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures, Neurobiol. Aging, 22, 187, 10.1016/S0197-4580(00)00235-9

Lovell, 2005, Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide, Neurochem. Res., 30, 113, 10.1007/s11064-004-9692-5

Maren, 1988, The kinetics of HCO3− synthesis related to fluid secretion, pH control, and CO2 elimination, Annu. Rev. Physiol., 50, 695, 10.1146/annurev.ph.50.030188.003403

Mark, 1997, A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide, J. Neurochem., 68, 255, 10.1046/j.1471-4159.1997.68010255.x

Markesbery, 1997, Oxidative stress hypothesis in Alzheimer's disease, Free Radical Biol. Med., 23, 134, 10.1016/S0891-5849(96)00629-6

Markesbery, 1999, Oxidative alterations in Alzheimer's disease, Brain Pathol., 9, 133, 10.1111/j.1750-3639.1999.tb00215.x

Matsuyama, 1998, The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells, Mol. Cell, 1, 327, 10.1016/S1097-2765(00)80033-7

Mattson, 2002, Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders, Neuromol. Med., 2, 215, 10.1385/NMM:2:2:215

Maurer, 2005, Comparison of statistical approaches for the analysis of proteome expression data of differentiating neural stem cells, J. Proteome Res., 4, 96, 10.1021/pr049841l

Mazzola, 2001, Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts, J. Neurochem., 76, 442, 10.1046/j.1471-4159.2001.00033.x

McKhann, 1984, Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, 34, 939, 10.1212/WNL.34.7.939

Meier-Ruge, 1984, Neurochemical enzyme changes in Alzheimer's and Pick's disease, Arch. Gerontol. Geriatr., 3, 161, 10.1016/0167-4943(84)90007-4

Messier, 1996, Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes, Behav. Brain Res., 75, 1, 10.1016/0166-4328(95)00153-0

Molina, 1997, Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease, Neurology, 48, 636, 10.1212/WNL.48.3.636

Osuka, 2002, Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia, J. Cereb. Blood Flow Metab., 22, 1098, 10.1097/00004647-200209000-00007

Ottesen, 2001, Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia, Free Radical Biol. Med., 31, 790, 10.1016/S0891-5849(01)00647-5

Pancholi, 2001, Multifunctional alpha-enolase: its role in diseases, Cell. Mol. Life Sci., 58, 902, 10.1007/PL00000910

Parnetti, 1995, Cerebrospinal fluid neuron-specific enolase in Alzheimer's disease and vascular dementia, Neurosci. Lett., 183, 43, 10.1016/0304-3940(94)11110-5

Poon, 2004, Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain, Neuroscience, 126, 915, 10.1016/j.neuroscience.2004.04.046

Pryor, 1995, The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide, Am. J. Physiol., 268, L699

Radi, 1994, Inhibition of mitochondrial electron transport by peroxynitrite, Arch. Biochem. Biophys., 308, 89, 10.1006/abbi.1994.1013

Rapoport, 1999, In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer's disease, Eur. Arch. Psychiatry Clin. Neurosci., 249, 46, 10.1007/PL00014174

Rapoport, 1991, Abnormal brain glucose metabolism in Alzheimer's disease, as measured by position emission tomography, Adv. Exp. Med. Biol., 291, 231, 10.1007/978-1-4684-5931-9_18

Schagger, 1995, Human diseases with defects in oxidative phosphorylation. 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis, Eur. J. Biochem., 227, 916, 10.1111/j.1432-1033.1995.tb20219.x

Sergeant, 2003, Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease, Neuroscience, 117, 293, 10.1016/S0306-4522(02)00747-9

Shimizu, 1999, Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC, Naturea, 399, 483, 10.1038/20959

Sly, 1995, Human carbonic anhydrases and carbonic anhydrase deficiencies, Annu. Rev. Biochem., 64, 375, 10.1146/annurev.bi.64.070195.002111

Sly, 1983, Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification, Proc. Natl. Acad. Sci. U. S. A., 80, 2752, 10.1073/pnas.80.9.2752

Sly, 1985, Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification, N. Engl. J. Med., 313, 139, 10.1056/NEJM198507183130302

Smith, 1994, Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease, Ann. N. Y. Acad. Sci., 738, 447, 10.1111/j.1749-6632.1994.tb21836.x

Smith, 1997, Widespread peroxynitrite-mediated damage in Alzheimer's disease, J. Neurosci., 17, 2653, 10.1523/JNEUROSCI.17-08-02653.1997

Stadtman, 1997, Reactive oxygen-mediated protein oxidation in aging and disease, Chem. Res. Toxicol., 10, 485, 10.1021/tx960133r

Su, 1997, Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain, Brain Res., 774, 193, 10.1016/S0006-8993(97)81703-9

Sultana, 2004, Oxidatively modified GST and MRP1 in Alzheimer’s disease brain: implications for accumulation of reactive lipid peroxidation products, Neurochem. Res., 29, 2215, 10.1007/s11064-004-7028-0

Sultana, R., Boyd-Kimball, D., Poon, H.F., Cai, J., Pierce, W.M., Klein, J., Markesbery, W.R., Zhou, X.Z., Lu, K.P., and Butterfield, D.A., in press-a. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: a redox proteomics analysis. Neurobiol. Aging.

Sultana, R., Boyd-Kimball, D., Poon, H.F., Cai, J., Pierce, W.M., Klein, J., Merchant, M., Markesbery, W.R., and Butterfield, D.A., in press-b Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD. Neurobiol. Aging.

Susin, 1999, Mitochondrial release of caspase-2 and -9 during the apoptotic process, J. Exp. Med., 189, 381, 10.1084/jem.189.2.381

Thongboonkerd, 2002, Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors, J. Biol. Chem., 277, 16599, 10.1074/jbc.M200746200

Tohgi, 1999, Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease, Neurosci. Lett., 269, 52, 10.1016/S0304-3940(99)00406-1

Vanhanen, 1998, Glucose intolerance, cognitive impairment and Alzheimer's disease, Curr. Opin. Neurol., 11, 673, 10.1097/00019052-199812000-00011

Vannucci, 2000, Glucose metabolism in the developing brain, Semin. Perinatol., 24, 107, 10.1053/sp.2000.6361

Varadarajan, 2000, Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity, J. Struct. Biol., 130, 184, 10.1006/jsbi.2000.4274

Verbeek, 2003, Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases, Ann. Clin. Biochem., 40, 25, 10.1258/000456303321016141

Walker, 2001, Oxidative stress and reactive nitrogen species generation during renal ischemia, Toxicol. Sci., 63, 143, 10.1093/toxsci/63.1.143

Weeber, 2002, The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity, J. Biol. Chem., 277, 18891, 10.1074/jbc.M201649200

Yamakura, 1998, Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine, J. Biol. Chem., 273, 14085, 10.1074/jbc.273.23.14085

Yoo, 2001, Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome, Electrophoresis, 22, 172, 10.1002/1522-2683(200101)22:1<172::AID-ELPS172>3.0.CO;2-P

Zou, 1999, Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase, J. Exp. Med., 190, 135, 10.1084/jem.190.1.135