Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors

Roger A.H. Adan1, Julia Oosterom1, Gudbjörg Ludvigsdottir1, Jan H. Brakkee1, J.Peter H. Burbach1, Willem Hendrik Gispen1
1Rudolf Magnus Institute for Neuroscience, Department of Medical Pharmacology, Utrecht University, P.O. Box 80040, 3508 TA Utrecht, Netherlands

Tài liệu tham khảo

Arunlakshana, 1959, Some quantative uses of drug antagonists, Br. J. Pharmacol., 14, 48 Barrett, 1994, Cloning and expression of a new member of the melanocyte-stimulating hormone receptor family, J. Mol. Endocrinol., 12, 203, 10.1677/jme.0.0120203 Bijlsma, 1981, Effects of corticotropin (ACTH) on recovery of sensorimotor function in the rat: structure-activity study, Eur. J. Pharmacol., 76, 73, 10.1016/0014-2999(81)90011-X Brakkee, 1979, A simple technique for rapid implantation of a permanent cannula into the rat brain ventricular system, Lab. Animal Sci., 29, 78 Catania, 1993, α-Melanocyte stimulating hormone in the modulation of host reactions, Endocr. Rev., 14, 564 Chhajlani, 1992, Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA, FEBS Lett., 309, 417, 10.1016/0014-5793(92)80820-7 Chhajlani, 1993, Molecular cloning of a novel human melanocortin receptor, Biochem. Biophys. Res. Commun., 195, 866, 10.1006/bbrc.1993.2125 Colbere-Garapin, 1981, A new dominant selective marker for higher eukaryotic cells, J. Mol. Biol., 150, 1, 10.1016/0022-2836(81)90321-1 De Wied, 1982, Neuropeptides derived from pro-opiomelanocortin: behavioral, physiological, and neurochemical effects, Physiol. Rev., 62, 976, 10.1152/physrev.1982.62.3.976 De Wildt, 1993, The hemodynamic effects of γ2-melanocyte-stimulating hormone and related melanotropins depend on the arousal potential of the rat, Eur. J. Pharmacol., 233, 157, 10.1016/0014-2999(93)90362-L Eberle, 1988 Florijn, 1993, Adenocorticotropin / α-melanocyte-stimulating hormone (ACTH/MSH)-loike peptides modulate adenylate cyclase activity in rat brain slices: evidence for an ACTH/MSH receptor coupled mechanism, J. Neurochem., 6, 2204, 10.1111/j.1471-4159.1993.tb03506.x Frandsen, 1977, A sensitive radioimmunoassay for the detection of cAMP, Life Sci., 18, 529, 10.1016/0024-3205(76)90331-3 Gantz, 1993, Molecular cloning of a novel melanocortin receptor, J. Biol. Chem., 268, 8246, 10.1016/S0021-9258(18)53088-X Gantz, 1993, Molecular cloning, expression, and gene localization of a fourth melanocortin receptor, J. Biol. Chem., 268, 15174, 10.1016/S0021-9258(18)82452-8 Gispen, 1975, The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: structure-activity studies, Life Sci., 17, 645, 10.1016/0024-3205(75)90103-4 Greven, 1977, Influence of peptides structurally related to ACTH and MSH on active avoidance behavior, Front. Hormone Res., 4, 140, 10.1159/000400359 Low, 1994, Receptors for the melanocortin peptides in the central nervous system, Curr. Opin. Endocrinol. Biab., 1, 79, 10.1097/00060793-199400010-00016 Mountjoy, 1992, The cloning of a family of genes that encode the melanocortin receptors, Science, 257, 1248, 10.1126/science.1325670 Mountjoy, 1994, Cloning and functional characterization of a melanocortin receptor (MC4-R) localized in neuroendocrine and autonomic circuitry in the brain, Mol. Endocrinol. Rehfuss-Roselli, 1993, Identification of a receptor for melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system, 90, 8856 Spruijt, 1985, Comparison of structural requirements of αMSH and ACTH for inducing excessive grooming and pigment dispersion, Peptides, 6, 1185, 10.1016/0196-9781(85)90448-6 Spruijt, 1986, The periaquaductal gray: a prerequisite for ACTH-induced excessive grooming, Behav. Brain Res., 20, 19, 10.1016/0166-4328(86)90097-5 Spruijt, 1992, Ethology and neurobiology of grooming behavior, Physiol. Rev., 72, 825, 10.1152/physrev.1992.72.3.825 Van der Eb, 1980, Assay for tranforming activity of tumor virus DNA, Methods Enzymol., 65, 826, 10.1016/S0076-6879(80)65077-0 Van Der Zee, 1991, Putative neurotrophic factors and functional recovery from peripheral nerve damage in the rat, Br. J. Pharmacol., 103, 1041, 10.1111/j.1476-5381.1991.tb12297.x Wiegant, 1979, Intracerebroventricular ACTH activates the pituitary-adrenal system: dissociation from a behavioral response, Life Sci., 25, 1791, 10.1016/0024-3205(79)90425-9