Identification of a novel ALK variant intrinsically resistant to crizotinib

Current Problems in Cancer: Case Reports - Tập 2 - Trang 100040 - 2020
Ullas Batra1, Shrinidhi Nathany2, Mansi Sharma1, Satyajeet Soni1, Parveen Jain1, Sunil Pasricha3, Abhishek Bansal4, Anurag Mehta5
1Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Center, Sector 5, Rohini, New Delhi 110085, India
2Molecular Diagnostics, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India
3Department of Pathology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India
4Department of Radiology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India
5Laboratory Services, Molecular Diagnostics and Transfusion Medicine, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India

Tài liệu tham khảo

Anai S., Masafumi T., Ando N., et al. A case of lung adenocarcinoma resistant to crizotinib harboring a novel EML4-ALK variant, exon 6 of EML4 fused to exon 18 of ALK. (2016);11(10):126–128. doi:10.1016/j.jtho.2016.07.008. Barlesi, 2016, Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French cooperative thoracic intergroup (IFCT), Lancet, 387, 1415, 10.1016/S0140-6736(16)00004-0 Doebele R.C., Pilling A.B., Aisner D.L., et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non - small cell lung cancer. 2012;18(5):1472–1483. doi:10.1158/1078-0432.CCR-11-2906. Gaughan, 2011, Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities, Ther. Adv. Med. Oncol., 3, 113, 10.1177/1758834010397569 Landrum, 2018, ClinVar: improving access to variant interpretations and supporting evidence, Nucleic Acids Res., 46, D1062, 10.1093/nar/gkx1153 Network NCC. Non-small cell lung cancer (version3.2020). https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf. Published 2020. Accessed April 10, 2020. Tate, 2019, COSMIC: the catalogue of somatic mutations, Cancer Nucleic Acids Res., 47, D941, 10.1093/nar/gky1015