Identification of PP2A as a crucial regulator of the NF-κB feedback loop: its inhibition by UVB turns NF-κB into a pro-apoptotic factor
Tóm tắt
Từ khóa
Tài liệu tham khảo
Delhase M, Hayakawa M, Chen Y, Karin M . Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999; 284: 309–313.
Huang TT, Kudo N, Yoshida M, Miyamoto S . A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci USA 2000; 97: 1014–1019.
Luque I, Gelinas C . Rel/NF-kappa B and I kappa B factors in oncogenesis. Semin Cancer Biol 1997; 8: 103–111.
Kothny-Wilkes G, Kulms D, Luger TA, Kubin M, Schwarz T . Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. J Biol Chem 1999; 274: 28916–28921.
Pöppelmann B, Klimmek K, Strozyk E, Voss R, Schwarz T, Kulms D . NFκB-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis. J Biol Chem 2005; 280: 15635–15643.
Rocha S, Campbell KJ, Perkins ND . p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. Mol Cell 2003; 12: 15–25.
Campbell KJ, Rocha S, Perkins ND . Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 2004; 13: 853–865.
Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND . Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 2005; 24: 1157–1169.
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M . A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1997; 388: 548–554.
Micheau O, Tschopp J . Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181–190.
Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J et al. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 2004; 21: 415–428.
Thoma B, Grell M, Pfizenmaier K, Scheurich P . Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses. J Exp Med 1990; 172: 1019–1023.
Kato Jr T, Delhase M, Hoffmann A, Karin M . CK2 is a C-terminal IkappaB kinase responsible for NF-kappaB activation during the UV response. Mol Cell 2003; 12: 829–839.
Kray AE, Carter RS, Pennington KN, Gomez RJ, Sanders LE, Llanes JM et al. Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A. J Biol Chem 2005; 280: 35974–35982.
Yarosh DB, Kripke ML . DNA repair and cytokines in antimutagenesis and anticarcinogenesis. Mutat Res 1996; 350: 255–260.
Kulms D, Schwarz T . 20 years after – milestones in molecular photobiology. J Investig Dermatol Symp Proc 2002; 7: 46–50.
Murphy G, Young AR, Wulf HC, Kulms D, Schwarz T . The molecular determinants of sunburn cell formation. Exp Dermatol 2001; 10: 155–160.
Kupper TS, Ballard DW, Chua AO, McGuire JS, Flood PM, Horowitz MC et al. Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1. J Exp Med 1986; 164: 2095–2100.
Feldmeyer L, Keller M, Niklaus G, Hohl D, Werner S, Beer HD . The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 2007; 17: 1140–1145.
Kondo S, Sauder DN, Kono T, Galley KA, McKenzie RC . Differential modulation of interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) in human epidermal keratinocytes by UVB. Exp Dermatol 1994; 3: 29–39.
Barker JN, Mitra RS, Griffiths CE, Dixit VM, Nickoloff BJ . Keratinocytes as initiators of inflammation. Lancet 1991; 337: 211–214.
Strozyk E, Pöppelmann B, Schwarz T, Kulms D . Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene 2006; 25: 6239–6251.
Aragane Y, Kulms D, Metze D, Wilkes G, Pöppelmann B, Luger TA et al. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol 1998; 140: 171–182.
Rosette C, Karin M . Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 1996; 274: 1194–1197.
Huang TT, Feinberg SL, Suryanarayanan S, Miyamoto S . The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Mol Cell Biol 2002; 22: 5813–5825.
Bender K, Gottlicher M, Whiteside S, Rahmsdorf HJ, Herrlich P . Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV. EMBO J 1998; 17: 5170–5181.
Adam E, Quivy V, Bex F, Chariot A, Collette Y, Vanhulle C et al. Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol 2003; 23: 6200–6209.
Li S, Wang L, Berman MA, Zhang Y, Dorf ME . RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol Cell 2006; 24: 497–509.
Sun SC, Maggirwar SB, Harhaj E . Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. J Biol Chem 1995; 270: 18347–18351.
Traenckner EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, Baeuerle PA . Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J 1995; 14: 2876–2883.
Sung SJ, Walters JA . Stimulation of interleukin-1 alpha and interleukin-1 beta production in human monocytes by protein phosphatase 1 and 2A inhibitors. J Biol Chem 1993; 268: 5802–5809.
Hong S, Wang LC, Gao X, Kuo YL, Liu B, Merling R et al. Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax. J Biol Chem 2007; 282: 12119–12126.
Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB . The phosphorylation of serine 68 in the IKK-binding domain of NEMO interferes with the structure of the IKK-complex and the TNF-alpha -induced NF-kappa B activity. J Biol Chem 2007; 283: 76–86.
Karin M, Yamamoto Y, Wang QM . The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov 2004; 3: 17–26.
Voorhees PM, Dees EC, O’Neil B, Orlowski RZ . The proteasome as a target for cancer therapy. Clin Cancer Res 2003; 9: 6316–6325.