Identification of IMPA2 as the hub gene associated with colorectal cancer and liver metastasis by integrated bioinformatics analysis

Translational Oncology - Tập 21 - Trang 101435 - 2022
Liuli Wang1,2, Deming Liu3, Shuo Liu2, Tianyi Liao2, Yajun Jiao3, Xianglai Jiang3, Yongfeng Wang4, Yaqiong Chen5, Haizhong Ma6, Hui Cai1,2
1Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730000, China
2The First Clinical Medical College of Lanzhou University, No. 199, Donggang WestRoad, Chengguan District, Lanzhou, Gansu 730000, China
3Ningxia Medical University, Ningxia 750004, China
4Department of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
5Medical Department of Gansu Provincial Hospital, Lanzhou 730000, China
6Department of Quality Control, Gansu Provincial Hospital, Lanzhou 730000, China

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Sung, 2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin., 71, 209, 10.3322/caac.21660

Testa, 2018, Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells, Med. Sci., 6

Engstrand, 2018, Colorectal cancer liver metastases - a population-based study on incidence, management and survival, BMC Cancer, 18, 78, 10.1186/s12885-017-3925-x

Landreau, 2015, Incidence and survival in late liver metastases of colorectal cancer, J. Gastroenterol. Hepatol., 30, 82, 10.1111/jgh.12685

Manfredi, 2006, Epidemiology and management of liver metastases from colorectal cancer, Ann. Surg., 244, 254, 10.1097/01.sla.0000217629.94941.cf

Can, 2014, Introduction to bioinformatics, Methods Mol. Biol., 1107, 51, 10.1007/978-1-62703-748-8_4

Li, 2020, Identification of hub genes associated with development of head and neck squamous cell carcinoma by integrated bioinformatics analysis, Front Oncol., 10, 681, 10.3389/fonc.2020.00681

Segundo-Val, 2016, Introduction to the gene expression analysis, Methods Mol. Biol., 1434, 29, 10.1007/978-1-4939-3652-6_3

Makondi, 2019, Development of novel predictive miRNA/target gene pathways for colorectal cancer distance metastasis to the liver using a bioinformatic approach, PLoS One, 14, 10.1371/journal.pone.0211968

Zhang, 2019, Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments, Oncol. Rep., 41, 279

Qian, 2017, Integrated analysis of genes associated with poor prognosis of patients with colorectal cancer liver metastasis, Oncotarget, 8, 25500, 10.18632/oncotarget.16064

Zhang, 2021, Identification of candidate biomarkers and prognostic analysis in colorectal cancer liver metastases, Front. Oncol., 11

Langfelder, 2008, WGCNA: an R package for weighted correlation network analysis, BMC Bioinform., 9, 559, 10.1186/1471-2105-9-559

Wan, 2018, Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma, Exp. Eye Res., 166, 13, 10.1016/j.exer.2017.10.007

Del Rio M, 2013, Specific extracellular matrix remodeling signature of colon hepatic metastases, PLoS One, 773

Sayagués JM, 2016, Genomic characterization of liver metastases from colorectal cancer patients, Oncotarget, 72908, 10.18632/oncotarget.12140

Marisa L, 2013, Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value, PLoS Med, e1001453, 10.1371/journal.pmed.1001453

Sheffer M, 2009, Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer, Proc Natl Acad Sci U S A, 7131, 10.1073/pnas.0902232106

Smith JJ, 2010, Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer, Gastroenterology, 958, 10.1053/j.gastro.2009.11.005

Davis, 2007, GEOquery: a bridge between the gene expression omnibus (GEO) and BioConductor, Bioinformatics, 23, 1846, 10.1093/bioinformatics/btm254

Ritchie, 2015, limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucl. Acids Res., 43, e47, 10.1093/nar/gkv007

Langfelder, 2008, WGCNA: an R package for weighted correlation network analysis, BMC Bioinform., 9, 559, 10.1186/1471-2105-9-559

Tang, 2017, GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses, Nucl. Acids Res., 45, 10.1093/nar/gkx247

Pagano, 1995, Simple linear regression and correlation, Nutrition, 11, 179

Yu, 2012, clusterProfiler: an R package for comparing biological themes among gene clusters, OMICS, 16, 284, 10.1089/omi.2011.0118

Ito, 2013, Application of ggplot2 to pharmacometric graphics, CPT Pharm. Syst. Pharmacol., 2, e79, 10.1038/psp.2013.56

Koch, 2015, MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data, BMC Genom., 16, 636, 10.1186/s12864-015-1847-z

Koch, 2019, MEXPRESS update 2019, Nucleic. Acids Res., 47, 10.1093/nar/gkz445

Cerami, 2012, The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discov., 2, 401, 10.1158/2159-8290.CD-12-0095

Jung, 2016, Risk factors for cancer recurrence or death within 6 months after liver resection in patients with colorectal cancer liver metastasis, Ann. Surg. Treat. Res., 90, 257, 10.4174/astr.2016.90.5.257

Fortner, 1988, Recurrence of colorectal cancer after hepatic resection, Am. J. Surg., 155, 378, 10.1016/S0002-9610(88)80086-2

Yoshikawa, 1997, A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder, Mol. Psychiatry, 2, 393, 10.1038/sj.mp.4000325

Bloch, 2010, Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder, Prog. Neuropsychopharmacol. Biol. Psychiatry, 34, 1515, 10.1016/j.pnpbp.2010.08.015

Jesch, 2005, Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast, J. Biol. Chem., 280, 9106, 10.1074/jbc.M411770200

Li, 2017, A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia, J. Cell. Mol. Med., 21, 658, 10.1111/jcmm.13009

Gurnett, 2007, New ideas in epilepsy genetics: novel epilepsy genes, copy number alterations, and gene regulation, Arch. Neurol., 64, 324, 10.1001/archneur.64.3.324

Tomioka, 2018, Association between genetic variation in the myo-inositol monophosphatase 2 (IMPA2) gene and age at onset of bipolar disorder, J. Affect. Disord., 232, 229, 10.1016/j.jad.2018.02.002

Sarkar, 2006, Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations, Autophagy, 2, 132, 10.4161/auto.2387

Ma, 2016, IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population, Oncotarget, 7, 75273, 10.18632/oncotarget.12133

Lin, 2019, Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma, EBioMed., 45, 220, 10.1016/j.ebiom.2019.06.006

Zhang, 2020, A novel function of IMPA2, plays a tumor-promoting role in cervical cancer, Cell Death. Dis., 11, 371, 10.1038/s41419-020-2507-z

Cheng, 2018, Lipid metabolism reprogramming and its potential targets in cancer, Cancer Commun., 38, 27, 10.1186/s40880-018-0301-4

Chen, 2019, Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells, Commun. Biol., 2, 281, 10.1038/s42003-019-0508-1

Cheng, 2020, Natural alkaloid and polyphenol compounds targeting lipid metabolism: treatment implications in metabolic diseases, Eur. J. Pharmacol., 870, 10.1016/j.ejphar.2020.172922

Pan, 2022, Therapeutic potential of melatonin in colorectal cancer: focus on lipid metabolism and gut microbiota, Biochim. Biophys. Acta Mol. Basis Dis., 1868, 10.1016/j.bbadis.2021.166281

Lu, 2019, Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway, Onco. Targets Ther., 12, 3339, 10.2147/OTT.S199369

Gao, 2019, SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation, BMC Cancer, 19, 685, 10.1186/s12885-019-5904-x

Ran, 2018, Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN, J. Exp. Clin. Cancer Res., 37, 54, 10.1186/s13046-018-0711-9

Hugo, 2007, Epithelial–mesenchymal and mesenchymal–epithelial transitions in carcinoma progression, J. Cell. Physiol., 213, 374, 10.1002/jcp.21223

Yilmaz, 2009, EMT, the cytoskeleton, and cancer cell invasion, Cancer Metastasis Rev., 28, 15, 10.1007/s10555-008-9169-0

Li, 2019, Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review), Oncol. Rep., 41, 727

Jiang, 2020, PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis, Cell Prolif., 53, e12705, 10.1111/cpr.12705

Wang, 2021, Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway, Clin. Transl. Med., 11, e522, 10.1002/ctm2.522

Belinsky, 2004, Gene-promoter hypermethylation as a biomarker in lung cancer, Nat. Rev. Cancer, 4, 707, 10.1038/nrc1432

Kang, 2004, Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia, J. Pathol., 202, 233, 10.1002/path.1503

Maruyama, 2002, Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features, Clin. Cancer Res., 8, 514