Identification of CpG oligodeoxynucleotide motifs that stimulate nitric oxide and cytokine production in avian macrophage and peripheral blood mononuclear cells

Janeway, 2002, Innate immune recognition, Annu Rev Immunol, 20, 197, 10.1146/annurev.immunol.20.083001.084359 Krieg, 2002, CpG motifs in bacterial DNA and their immune effects, Annu Rev Immunol, 20, 709, 10.1146/annurev.immunol.20.100301.064842 Bird, 1987, CpG islands as gene markers in the vertebrate nucleus, Trends Genet, 3, 342, 10.1016/0168-9525(87)90294-0 Häcker, 2002, Activation of the immune system by bacterial CpG-DNA, Immunology, 105, 245, 10.1046/j.0019-2805.2001.01350.x Yamamoto, 1992, Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity, J Immunol, 148, 4072, 10.4049/jimmunol.148.12.4072 Hemmi, 2000, A Toll-like receptor recognizes bacterial DNA, Nature, 408, 740, 10.1038/35047123 Bauer, 2001, Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition, Proc Natl Acad Sci USA, 98, 9237, 10.1073/pnas.161293498 Stacey, 1996, Macrophages ingest and are activated by bacterial DNA, J Immunol, 157, 2116, 10.4049/jimmunol.157.5.2116 Yi, 1996, IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oigodeoxynucleotides, J Immunol, 156, 558, 10.4049/jimmunol.156.2.558 Chace, 1997, Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12, Clin Immunol Immunopathol, 84, 185, 10.1006/clin.1997.4380 Sun, 1998, Type I interferon-mediated stimulation of T cells by CpG DNA, J Exp Med, 188, 2335, 10.1084/jem.188.12.2335 Jakob, 1999, Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses, Int Arch Allergy Immunol, 118, 457, 10.1159/000024163 Hartmann, 2000, Delineation of CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo, J Immunol, 164, 1617, 10.4049/jimmunol.164.3.1617 Hartmann, 2000, Mechanism and function of a newly identified CpG DNA motif in human primary B cells, J Immunol, 164, 944, 10.4049/jimmunol.164.2.944 Tascon, 2000, Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells, Immunol, 99, 1, 10.1046/j.1365-2567.2000.00941.x Krug, 2001, Identification of CpG oligonucleotides sequences with high induction of IFN-α/β in plasmacytoid dendritic cells, Eur J Immunol, 31, 2154, 10.1002/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U Verthelyi, 2001, Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs, J Immunol, 166, 2372, 10.4049/jimmunol.166.4.2372 Ballas, 2001, Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs, J Immunol, 167, 4878, 10.4049/jimmunol.167.9.4878 Kamstrup, 2001, Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides, Vet Microbiol, 78, 353, 10.1016/S0378-1135(00)00300-X Zhang, 2001, Induction of interleukin-6 and interleukin-12 in bovine B lymphocytes, monocytes and macrophages by a CpG oligodeoxynucleotide (ODN 2059) containing the GTCGTT motif, J Interferon Cytokine Res, 21, 871, 10.1089/107999001753238123 Krieg, 1995, CpG motifs in bacterial DNA trigger direct B-cell activation, Nature, 374, 546, 10.1038/374546a0 Klinman, 1996, CpG motifs expressed by bacterial DNA apidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ, Proc Natl Acad Sci USA, 93, 2879, 10.1073/pnas.93.7.2879 Yi, 1998, CpG oligodeoxynucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry, J Immunol, 160, 5898, 10.4049/jimmunol.160.12.5898 Krieg, 1998, The role of CpG dinucleotides in DNA vaccines, Trends Microbiol, 6, 23, 10.1016/S0966-842X(97)01145-1 Dalpke, 2002, Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo, Immunology, 106, 102, 10.1046/j.1365-2567.2002.01410.x Sester, 2000, Phosphorothioate backbone modification modulates macrophage activation by CpG DNA, J Imunol, 165, 4165, 10.4049/jimmunol.165.8.4165 Hartmann, 1996, Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on Phosphorothioate modification and reversal by heparin, Mol Med, 2, 429, 10.1007/BF03401902 Well, 1998, Age-dependent phagocytosis and bactericidal activities of the chicken heterophil, Del Comp Immunol, 22, 103, 10.1016/S0145-305X(97)00024-4 Krieg, 1998, CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge, J Immunol, 161, 2428, 10.4049/jimmunol.161.5.2428 Klinman, 1999, Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection, Infect Immun, 67, 5658, 10.1128/IAI.67.11.5658-5663.1999 Zimmermann, 1998, CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis, J Immunol, 160, 3627, 10.4049/jimmunol.160.8.3627 Kogut, 1995, In vivo activation of heterophil function in chickens following injection with Salmonella enteritidis-immune lymphokines, J Leukoc Biol, 57, 56, 10.1002/jlb.57.1.56 Gogal, 1997, Analysis of avian lymphocyte proliferation by a new, simple, nonradioactive assay (Lympho-pro), Avian Dis, 41, 714, 10.2307/1592166 Green, 1982, Analysis of nitrate, nitrite and [15N]nitrate in biological fluids, Analyt Biochem, 126, 131, 10.1016/0003-2697(82)90118-X Eisenstein, 2001, Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule, Microbes Infec, 1223, 10.1016/S1286-4579(01)01482-4 MacMicking, 1997, Nitric oxide and macrophage function, Annu Rev Immunol, 15, 323, 10.1146/annurev.immunol.15.1.323 Gao, 1999, Cutting edge: bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages, J Immunol, 163, 4095, 10.4049/jimmunol.163.8.4095 Ghosh, 2001, Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages, Infect Immun, 69, 7703, 10.1128/IAI.69.12.7703-7710.2001 Utaisincharoen, 2002, CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7), Clin Exp Immunol, 128, 467, 10.1046/j.1365-2249.2002.01866.x Nathan, 2000, Reactive oxygen and nitrogen intermediates in the relationship between hosts and microbial pathogens, Proc Natl Acad Sci USA, 97, 8841, 10.1073/pnas.97.16.8841 Djeraba, 2002, Similar pattern of iNOS expression, NO production and cytokine response in genetic and vaccination-aquired resistance to Marek's disease, Vet Immunol Immunopathol, 85, 63, 10.1016/S0165-2427(01)00412-3 Jørgensen, 2001, CpG oligodeoxynucleotides and plasmid DNA stimulate Atlantic salmon (Salmo salar L) leucocytes to produce supernatants with antiviral activity, Dev Comp Immunol, 25, 313, 10.1016/S0145-305X(00)00068-9