Identification of α-thalassemia mutations in subjects from Eastern Sicily (Italy) with abnormal hematological indices and normal Hb A2

Chiara Di Bella1, Carmelo Salpietro1, Michele La Rosa1, Caterina Cuppari1, Basilia Piraino1, Maria Rosa Cutrì1, Luciana Rigoli1
1Unità Operativa di Genetica, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, pad NI, Policlinico Universitario, Messina, Italy

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Bernini LF (2001) Geographic distribution of alpha-thalassemia. In: Steinberg MH, Forget BG, Higgs DR et al (eds) Disorders of hemoglobin: genetics, pathophysiology, and clinical management. Cambridge University Press, New York, pp 878–894

Bianco I, Graziani B, Foglietta E (1996) Molecular basis of α-thalassemia in Latinum (Italy). Br J Haematol Suppl 93:23

Buckle VJ, Higgs DM, Wilkie AO, Super M, Weatherall DJ (1988) Localisation of human alpha globin to 16p13.3—pter. J Med Genet 25:847–849

Cohen AR, Galanello R, Pennell DJ, Cunningham MJ, Vichinsky E (2004) Thalassemia. Hematology Am Soc Hematol Educ Program: 14–34

Fichera M, Spalletta A, Fiorenza F, Lombardo T, Schiliro’ G, Tamouza R, Lapouméroulie C, Labie D, Ragusa A (1997) Molecular basis of α-thalassemia in Sicily. Hum Genet 99:381–386

Giambona A, Lo Gioco P, Marino M, Abate I, Di Marzo R, Renda M, Di Trapani F, Messana F, Siciliano S, Rigano P (1995) The great heterogeneity of thalassemia molecular defects in Sicily. Hum Genet 95:526–530

Kattamis AC, Camaschella C, Sivera P, Surrey S, Fortina P (1996) Human alpha-thalassemia syndromes: detection of molecular defects. Am J Hematol 53:81–91

Sambrook J, Fritsch EF, Maniatis T (1991) In: Molecular cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 865–870

Steinberg MH, Adams JG (1991) Hemoglobin A2: origin, evolution, and aftermath. Blood 78:2165–2177

Steinberg MH, Forget BG, Higgs DR, Nagel RL (2001) Molecular mechanisms of alpha thalassemia. In: disorders of haemoglobin—genetics, pathophysiology and clinical management, vol. 17. Cambridge University Press, New York, pp 405–430

Villegas A, Ropero P, Gonzales FA, Anguita E, Espinos D (2001) The thalassemia syndromes: molecular characterization in the Spanish population. Hemoglobin 25:273–283

Weatherall DJ (2004) Thalassaemia: the long road from bedside to genome. Nat Rev Genet 5:625–631