Identification and management of Shigella infection in children with diarrhoea: a systematic review and meta-analysis

Kotloff, 2013, Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study, Lancet, 382, 209, 10.1016/S0140-6736(13)60844-2 Liu, 2016, Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study, Lancet, 388, 1291, 10.1016/S0140-6736(16)31529-X O'Reilly, 2012, Risk factors for death among children less than 5 years old hospitalized with diarrhea in rural western Kenya, 2005–2007: a cohort study, PLoS Med, 9, e1001256, 10.1371/journal.pmed.1001256 Islam, 1986, Morbidity and mortality in a diarrhoeal diseases hospital in Bangladesh, Trans R Soc Trop Med Hyg, 80, 748, 10.1016/0035-9203(86)90374-3 Afroze, 2017, Risk factors and outcome of Shigella encephalopathy in Bangladeshi children, PLoS Negl Trop Dis, 11, e0005561, 10.1371/journal.pntd.0005561 Khan, 2013, Gastrointestinal and extra-intestinal manifestations of childhood shigellosis in a region where all four species of Shigella are endemic, PLoS One, 8, e64097, 10.1371/journal.pone.0064097 2005 2005 Ronsmans, 1988, Diagnosis and management of dysentery by community health workers, Lancet, 2, 552, 10.1016/S0140-6736(88)92669-4 Bennish, 1990, Death in shigellosis: incidence and risk factors in hospitalized patients, J Infect Dis, 161, 500, 10.1093/infdis/161.3.500 Prince Christopher, 2010, Antibiotic therapy for Shigella dysentery, Cochrane Database Syst Rev, 1 Livio, 2014, Shigella isolates from the global enteric multicenter study inform vaccine development, Clin Infect Dis, 59, 933, 10.1093/cid/ciu468 von Seidlein, 2006, A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology, PLoS Med, 3, e353, 10.1371/journal.pmed.0030353 Khatun, 2011, Changing species distribution and antimicrobial susceptibility pattern of Shigella over a 29-year period (1980–2008), Epidemiol Infect, 139, 446, 10.1017/S0950268810001093 Atkins, 2004, Grading quality of evidence and strength of recommendations, BMJ, 328, 1490, 10.1136/bmj.328.7454.1490 Whiting, 2003, The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews, BMC Med Res Methodol, 10, 3 Dutta, 1995, Assessing the cause of in-patients pediatric diarrheal deaths: an analysis of hospital records, Indian Pediatr, 32, 313 Pernica, 2016, Correlation of clinical outcomes with multiplex molecular testing of stool from children admitted to hospital with gastroenteritis in Botswana, J Pediatric Infect Dis Soc, 5, 312, 10.1093/jpids/piv028 Teka, 1996, Risk factors for deaths in under-age-five children attending a diarrhoea treatment centre, Acta Paediatr, 85, 1070, 10.1111/j.1651-2227.1996.tb14219.x Uysal, 2000, Clinical risk factors for fatal diarrhea in hospitalized children, Indian J Pediatr, 67, 329, 10.1007/BF02820679 van den Broek, 2005, Risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in Bangladesh, J Health Popul Nutr, 23, 259 Pavlinac, 2016, Failure of Syndrome-based diarrhea management guidelines to detect Shigella infections in Kenyan children, J Pediatric Infect Dis Soc, 5, 366, 10.1093/jpids/piv037 Aggarwal, 2016, True prevalence of shigellosis in Indian children with acute gastroenteritis: have we been missing the diagnosis?, J Res Health Sci, 16, 11 Eseigbe, 2013, Bacterial isolates from the stools of children aged less than 5 years with acute diarrhea in Kaduna, Northwestern Nigeria, Ann Trop Med Public Health, 6, 452, 10.4103/1755-6783.127798 Hegde, 2013, Burden of laboratory-confirmed shigellosis infections in guatemala 2007–2012: results from a population-based surveillance system, Am J Trop Med Hyg, 89, 453 Dooki, 2014, Bacterial entropathogens and antimicrobial susceptibility in children with acute diarrhea in Babol, Iran, Caspian J Intern Med, 5, 30 Debas, 2011, Prevalence and antimicrobial susceptibility patterns of shigella species at Felege Hiwot Referral Hospital, Northwest Ethiopia, Ethiop Med J, 49, 249 El-Shabrawi, 2015, The burden of different pathogens in acute diarrhoeal episodes among a cohort of Egyptian children less than five years old, Prz Gastroenterol, 10, 173 Jafari, 2008, Acute diarrhea due to enteropathogenic bacteria in patients at hospitals in Tehran, Jpn J Infect Dis, 61, 269, 10.7883/yoken.JJID.2008.269 Ozmert, 2010, Sensitivity and specificity of bloody diarrhea in shigella gastroenteritis, Turk J Pediatr, 52, 488 Suwatano, 1997, Acute diarrhea in under five-year-old children admitted to King Mongkut Prachomklao Hospital, Phetchaburi province, J Med Assoc Thai, 80, 26 Youssef, 2000, Bacterial, viral and parasitic enteric pathogens associated with acute diarrhea in hospitalized children from northern Jordan, FEMS Immunol Med Microbiol, 28, 257, 10.1111/j.1574-695X.2000.tb01485.x Nakano, 1998, Diagnosis of bacterial enteric infections in children in Zambia, Acta Paediatr Jpn, 40, 259, 10.1111/j.1442-200X.1998.tb01924.x Mathan, 1991, Intestinal manifestations of invasive diarrheas and their diagnosis, Rev Infect Dis, 13, S311, 10.1093/clinids/13.Supplement_4.S311 Sobel, 2004, Pathogen-specific risk factors and protective factors for acute diarrheal illness in children aged 12–59 months in Sao Paulo, Brazil, Clin Infect Dis, 38, 1545, 10.1086/420822 Ahmed, 1997, Epidemiology of shigellosis among children exposed to cases of Shigella dysentery: a multivariate assessment, Am J Trop Med Hyg, 56, 258, 10.4269/ajtmh.1997.56.258 Kagalwalla, 1992, Childhood shigellosis in Saudi Arabia, Pediatr Infect Dis J, 11, 215, 10.1097/00006454-199203000-00009 Dutta, 1992, Shigellosis in children: a prospective hospital based study, Indian Pediatr, 29, 1125 Echeverria, 1991, Microbiology and diagnosis of infections with Shigella and enteroinvasive Escherichia coli, Rev Infect Dis, 13, S220, 10.1093/clinids/13.Supplement_4.S220 Moalla, 1994, Etiology of acute diarrhea in children, Tunis Med, 72, 25 Huskins, 1994, Shigellosis in neonates and young infants, J Pediatr, 125, 14, 10.1016/S0022-3476(94)70115-6 Stoll, 1982, Epidemiologic and clinical features of patients infected with Shigella who attended a diarrheal disease hospital in Bangladesh, J Infect Dis, 146, 177, 10.1093/infdis/146.2.177 Mo-Suwan, 1979, Clinical profile of diarrhoea at Ramathibodi Hospital during 1977, Southeast Asian J Trop Med Public Health, 10, 142 2017 Alam, 1994, Comparison of pivmecillinam and nalidixic acid in the treatment of acute shigellosis in children, Scand J Gastroenterol, 29, 313, 10.3109/00365529409094842 Basualdo, 2003, Randomized comparison of azithromycin versus cefixime for treatment of shigellosis in children, Pediatr Infect Dis J, 22, 374, 10.1097/01.inf.0000060829.48485.2e Bhattacharya, 1997, Double-blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children, Acta Paediatr, 86, 319, 10.1111/j.1651-2227.1997.tb08898.x Dutta, 1995, Comparative efficacy of furazolidone and nalidixic acid in the empirical treatment of acute invasive diarrhea: randomized clinical trial, Indian Pediatr, 32, 13 Gilman, 1980, Randomized trial of high- and low-dose ampicillin therapy for treatment of severe dysentery due to Shigella dysenteriae type 1, Antimicrob Agents Chemother, 17, 402, 10.1128/AAC.17.3.402 Gilman, 1981, Single-dose ampicillin therapy for severe shigellosis in Bangladesh, J Infect Dis, 143, 164, 10.1093/infdis/143.2.164 Helvaci, 1998, Comparative efficacy of cefixime and ampicillin–sulbactam in shigellosis in children, Acta Paediatr Jpn, 40, 131, 10.1111/j.1442-200X.1998.tb01896.x Islam, 1994, Double-blind comparison of oral gentamicin and nalidixic acid in the treatment of acute shigellosis in children, J Trop Pediatr, 40, 320, 10.1093/tropej/40.6.320 Moolasart, 1999, Comparison of the efficacy of ceftibuten and norfloxacin in the treatment of acute gastrointestinal infection in children, Southeast Asian J Trop Med Public Health, 30, 764 Prado Camacho, 1989, A comparison of furazolidone and ampicillin in the treatment of invasive diarrhea, Scand J Gastroenterol Suppl, 169, 54, 10.3109/00365528909091333 Prado, 1992, Ceftibuten and trimethoprim-sulfamethoxazole for treatment of Shigella and enteroinvasive Escherichia coli disease, Pediatr Infect Dis J, 11, 644 Prado, 1993, Comparative efficacy of pivmecillinam and cotrimoxazole in acute shigellosis in children, Scand J Infect Dis, 25, 713, 10.3109/00365549309008568 Rodriguez, 1989, A randomized, controlled, single-blind study comparing furazolidone with trimethoprim–sulfamethoxazole in the empirical treatment of acute invasive diarrhea, Scand J Gastroenterol Suppl, 169, 47, 10.3109/00365528909091332 Salam, 1988, Therapy for shigellosis. I. Randomized, double-blind trial of nalidixic acid in childhood shigellosis, J Pediatr, 113, 901, 10.1016/S0022-3476(88)80029-5 Salam, 1998, Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis, Lancet, 352, 522, 10.1016/S0140-6736(97)11457-X Taylor, 1987, Erythromycin-resistant Campylobacter infections in Thailand, Antimicrob Agents Chemother, 31, 438, 10.1128/AAC.31.3.438 Vinh, 2000, Treatment of bacillary dysentery in Vietnamese children: two doses of ofloxacin versus 5-days nalidixic acid, Trans R Soc Trop Med Hyg, 94, 323, 10.1016/S0035-9203(00)90343-2 Vinh, 2011, A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children, PLoS Negl Trop Dis, 5, e1264, 10.1371/journal.pntd.0001264 Yunus, 1982, Clinical trial of ampicillin v. trimethoprim-sulphamethoxazole in the treatment of Shigella dysentery, J Trop Med Hyg, 85, 195 2002, Multicenter, randomized, double blind clinical trial of short course versus standard course oral ciprofloxacin for Shigella dysenteriae type 1 dysentery in children, Pediatr Infect Dis J, 21, 1136, 10.1097/00006454-200212000-00010 de Widerspach-Thor, 2002, Predictive factors of mortality in severe shigellosis, Med Trop, 62, 101 Zaman, 1991, Surveillance of shigellosis in rural Bangladesh: a 10 years review, J Pak Med Assoc, 41, 75 Liu, 2014, Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicentre study, Lancet Infect Dis, 14, 716, 10.1016/S1473-3099(14)70808-4 Keddy, 2012, Systemic shigellosis in South Africa, Clin Infect Dis, 54, 1448, 10.1093/cid/cis224 Bennish, 1991, Potentially lethal complications of shigellosis, Rev Infect Dis, 13, S319, 10.1093/clinids/13.Supplement_4.S319 Gu, 2015, Comparison of resistance to third-generation cephalosporins in Shigella between Europe–America and Asia–Africa from 1998 to 2012, Epidemiol Infect, 143, 2687, 10.1017/S0950268814003446 Bennish, 1991, Mortality due to shigellosis: community and hospital data, Rev Infect Dis, 13, S245, 10.1093/clinids/13.Supplement_4.S245