Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

Chemistry & Biology - Tập 17 - Trang 1189-1200 - 2010
Melissa J. Leyva1, Francesco DeGiacomo2, Linda S. Kaltenbach3, Jennifer Holcomb2, Ningzhe Zhang2, Juliette Gafni2, Hyunsun Park4, Donald C. Lo3, Guy S. Salvesen5, Lisa M. Ellerby2, Jonathan A. Ellman6
1Department of Chemistry, University of California, Berkeley, CA 94720, USA
2Buck Institute for Age Research, Novato, CA 94945, USA
3Duke University Medical Center, Durham, NC 27704, USA
4CHDI Foundation Inc., Los Angeles, CA 90045, USA
5Burnham Institute for Medical Research, La Jolla, CA 92037, USA
6Department of Chemistry, Yale University, New Haven, CT 06437, USA

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