Ideas in Theoretical Biology Origin of Cancerous Cells from Tumours

Deng K. Niu, Jia-Kuan Chen

Tóm tắt

With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.

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Tài liệu tham khảo

Cairns, J., J. Overbaugh and S. Miller (1988). The origin of mutants. Nature 335: 142–145.

Dameron, K.M., O.V. Volpert, M.A. Tainsky and N. Bouck (1994). Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265: 1582–1584.

Foster, P.L. (1997). Nonadaptive mutations occur on the F'episome during adaptive mutation conditions in Escherichia coli. J. Bacteriol. 179: 1550–1554.

Graeber, T.G., C. Osmanian, T. Jacks, D.E. Housman, C.J. Koch, S.W. Lowe and A.J. Giaccia (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: 88–91.

Kinzler, K.W. and B. Vogelstein (1996). Life (and death) in a malignant tumour. Nature 379: 19–20.

Niu, D.K. and Y.F. Wang (1995). Why animals have tumours. Acta Biotheor. 43: 279–280.

Plate, K.H., G. Breier, H.A. Weich and W. Risau (1992). Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: 845–848.

Richards, B., H. Zhang, G. Phear, and M. Meuth (1997). Conditional mutator phenotypes in hMSH2-deficient tumor cell lines. Science 277: 1523–1526.

Shweiki, D., A. Itin, D. Soffer and E. Keshet (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843–845.

Strauss, B.S. (1992). The origin of point mutations in human tumor cells. Cancer Res. 52: 249–253.

Torkelson, J., R.S. Harris, M.-J. Lombardo, J. Nagendran, C. Thulin and S.M. Rosenberg (1997). Genome-wide hypermutation in a subpopulation of stationary-phrase cells underlies recombination-dependent adaptive mutation. EMBO J. 16: 3303–3311.