Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
Tóm tắt
Từ khóa
Tài liệu tham khảo
Norton,J. D. et al. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol. 8. 58–65 (1998).
Lassar,A. B., Skapek,S. X. & Novitch,B. Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr. Opin. Cell biol. 6, 788–794 (1994).
Ron,D. & Habener,J. F. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as dominant-negative inhibitor of gene transcription. Genes Dev. 6, 439–453 (1992).
Treacy,M. N., He,X. & Rosenfeld,M. G. I-POU: a POU-domain protein that inhibits neuron-specific gene activation. Nature 350, 577–584 (1991).
Yan,W. et al. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol. Cell Biol. 17, 7317–7327 (1997).
Deed,R. W., Jasiok,M. & Norton,J. D. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. 27, 8278–8286 (1998).
Ogata,T. et al. Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells. Proc. Natl Acad. Sci. USA 90, 9219–9222 (1993).
Neuman,T. et al. Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse. Dev. Biol. 160, 186–195 (1993).
Voronova,A. F. & Lee,F. The E2A and tal-1 helix-loop-helix proteins associated in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc. Natl Acad. Sci. USA 91, 5952–5956 (1994).
Heemskerk,M. H. et al. Inhibition of T cells and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J. Exp. Med. 186, 1597–1602 (1997).
Martinsen,B. J. & Bronner-Fraser,M. Neural crest specification regulated by the helix-loop-helix repressor Id2. Science 281, 988–991 (1998).
Katagiri,T. et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J. Cell Biol. 128, 713 (1995)]. J. Cell Biol. 127, 1755–1766 (1994).
Yokota,Y. et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397, 702–706 (1999).
Pan,L. et al. Impaired immune responses and B cell proliferation in mice lacking the Id3 gene. Mol. Cell Biol. 19, 5969–5980 (1999).
Duncan,M. et al. The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors. Dev. Biol. 154, 1–10 (1992).
Ellmeier,W. & Weith,A. Expression of the helix-loop-helix gene Id3 during murine embryonic development. Dev. Dyn. 203, 163–173 (1995).
Jen,Y., Manova,K. & Benezra,R. Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis. Dev. Dyn. 208, 92–106 (1997).
Lee,J. E. Basic helix-loop-helix genes in neural development. Curr. Opin. Neurobiol. 7, 13–20 (1997).
Xuan,S. et al. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14, 1141–1152 (1995).
Price,M. et al. A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature 351, 748–751 (1991).
Simeone,A. et al. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12, 2735–2747 (1993).
Walther,C. & Gruss,P. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113, 1435–1449 (1991).
Shimamura,K. et al. Longitudinal organization of the anterior neural plate and neural tube. Development 121, 3923–3933 (1995).
Bader,B. L. et al. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95, 507–519 (1998).
Bain,G. et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements [see comments]. Cell 79, 885–892 (1994).
Zhuang,Y., Soriano,P. & Weintraub,H. The helix-loop-helix gene E2A is required for B cell formation. Cell 79, 875–884 (1994).
Erickson,J. W. & Cline,T. W. Molecular nature of the Drosophila sex determination signal and its link to neurogenesis. Science 251, 1071–1074 (1991).
Brooks,P. C. et al. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85, 683–693 (1996).
Perlman,J. M. & Volpe,J. J. Intraventricular hemorrhage in extremely small premature infants. Am. J. Dis. Child. 140, 1122–1124 (1986).
Ishibashi,M. et al. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 9, 3136–3148 (1995).
Jen,Y., Weintraub,H. & Benezra,R. Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A protein. Genes Dev. 6, 1466–1479 (1992).
Melnikova,I. N. & Christy,B. A. Muscle cell differentiation is inhibited by the helix-loop-helix protein Id3. Cell Growth Differ. 7, 1067–1079 (1996).
Sherwood,A., Hopp,A. & Smith,J. F. Cellular reactions to subependymal plate haemorrhage in the human neonate. Neuropathol. Appl. Neurobiol. 4, 245–261 (1978).
Lindahl,P. et al. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277, 242–245 (1997).
Quertermous,E. E. et al. Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. Proc. Natl Acad. Sci. USA 91, 7066–7070 (1994).
Brooks,P. C. et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157–1164 (1994).
Desprez,P. Y. et al. A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol. Cell Biol. 18, 4577–4588 (1998).
O'Reilly,M. S. et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88, 277–285 (1997).
Boehm,T. et al. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [see comments]. Nature 390, 404–407 (1997).
Hogan,B. L. et al. Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. J. Embryol. Exp. Morphol. 97, 95–110 (1986).
Manova,K. et al. Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice. Dev. Dyn. 213, 293–308 (1998).
Akazawa,C. et al. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol. Chem. 270, 8730–8738 (1995).
McCormick,M. B. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. Mol. Cell Biol. 16, 5792–5800 (1996).
Lee,J. E. et al. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268, 836–844 (1995).
Simonson,M. S., Rooney,A. & Herman,W. H. Expression and differential regulation of Id1, a dominant negative regulator of basic helix-loop-helix transcription factors, in glomerular mesangial cells. Nucleic Acids Res. 21, 5767–5774 (1993).
Echelard,Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417–1430 (1993).
Jen,Y., Manova,K. & Benezra,R. Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis. Dev. Dyn. 207, 235–252 (1996).