Betsy M. Sutherland1, Rowena Oliver1
1Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92717 U.S.A.
Tóm tắt
Abstract— Cells from patients with xeroderma pigmentosum contain lowered levels of photoreactivating enzyme. We have examined the photoreactivating enzyme levels in cells from members of a family with three xeroderma children, one normal child and normal parents; the enzyme levels are consistent with a simple pattern of inheritance in which individuals with the normal enzyme level are PP, those with intermediate levels are PP, and those with very low enzyme levels are pp. We tested this hypothesis by examining enzyme levels in parent‐xeroderma child pairs in which the child possessed very low enzyme levels (pp). In all cases, the parents contained intermediate levels of enzyme (Pp). These results support the hypothesis of a simple pattern of inheritance of photoreactivating enzyme in humans.
