IMMUNE RESPONSES TO OSTEOCHONDRAL ALLOGRAFTS: NATURE AND SIGNIFICANCE

Orthopedics - Tập 15 Số 10 - Trang 1171-1175 - 1992
Gary E. Friedlaender1, Mark C. Horowitz
1Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Conn.

Tóm tắt

ABSTRACT Osteochondral allografts evoke immune responses. The nature of these immune responses and their biologic significance are still only partially understood. It is clear, however, that cell surface antigens of the major histocompatibility complex represented on the cellular elements of bone grafts cause T-cell activation, specifically those of the suppressor/cytotoxic phenotype. In numerous animal models, the most immunogenic bone allografts (mismatched, fresh) have demonstrated the poorest clinical and biologic outcomes, while more closely matched and/or grafts treated to reduce immunogenicity (frozen, freeze-dried) have more successfully incorporated. These observations support the hypothesis that immune responses against bone-graft related antigens have biologic significance and that reducing these responses may improve clinical results.

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Tài liệu tham khảo

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Orthopedics

Tập 15 Số 10

1171-1175

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