ILAE Official Report: A practical clinical definition of epilepsy

Epilepsia - Tập 55 Số 4 - Trang 475-482 - 2014
Robert S. Fisher1, Carlos Alberto Acevedo2, Alexis Arzimanoglou3, Alicia Bogacz4, J. Helen Cross5, Christian E. Elger6, Jerome Engel7, Lars Forsgren8, Jacqueline A. French9, Mike Glynn10, Dale C. Hesdorffer11, B. I. Lee12, Gary W. Mathern13, Solomon L. Moshé14, Emilio Perucca15, Ingrid E. Scheffer16, Torbjörn Tomson17, Masako Watanabe18, Samuel Wiebe19
1Department of Neurology & Neurological Sciences Stanford University School of Medicine Stanford California U.S.A
2SCH Past President Chilean League Against Epilepsy Santiago Chile
3Epilepsy, Sleep and Pediatric Neurophysiology Department, University Hospitals of Lyon (HCL) and Lyon Neuroscience Research Center (CRNL), Lyon, France
4Neurological Institute of Clinical Hospital Universidad Mayor de la República Montevideo Uruguay
5UCL‐Institute of Child Health Great Ormond Street Hospital for Children, London & Young Epilepsy Lingfield United Kingdom
6Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
7Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences UCLA Seizure Disorder Center David Geffen School of Medicine at UCLA Los Angeles California U.S.A
8Department of Pharmacology and Clinical Neuroscience, Neurology, Umeå University, Umeå, Sweden
9Department of Neurology NYU School of Medicine New York New York U.S.A
10CEO Epilepsy Ireland Dublin Ireland
11GH Sergievsky Center and Department of Epidemiology Columbia University New York New York U.S.A.
12Yonsei Epilepsy Research Institute; Yonsei University College of Medicine; Seoul Korea
13Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine Mattel Children's Hospital David Geffen School of Medicine University of California Los Angeles California U.S.A
14Saul R. Korey Department of Neurology Dominick P. Purpura Department of Neuroscience and Department of Pediatrics Laboratory of Developmental Epilepsy Montefiore/Einstein Epilepsy Management Center Albert Einstein College of Medicine and Montefiore Medical Center Bronx New York U.S.A
15Department of Internal Medicine and Therapeutics University of Pavia and C. Mondino National Neurological Institute Pavia Italy
16Departments of Medicine and Paediatrics, Florey Institute, Austin Health and Royal Children's Hospital, The University of Melbourne, Melbourne, Victoria, Australia
17Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
18Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
19University of Calgary, calgary, Alberta, canada

Tóm tắt

Summary

Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age‐dependent epilepsy syndrome but are now past the applicable age or who have remained seizure‐free for the last 10 years and off antiseizure medicines for at least the last 5 years. “Resolved” is not necessarily identical to the conventional view of “remission or “cure.” Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use.

A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.

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Epilepsia

Tập 55 Số 4

475-482

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