IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis

Sprent, 2011, Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells, Nature Immunology, 12, 478, 10.1038/ni.2018

Surh, 2008, Homeostasis of naive and memory T cells, Immunity, 29, 848, 10.1016/j.immuni.2008.11.002

Tough, 1994, Turnover of naive- and memory-phenotype T cells, The Journal of Experimental Medicine, 179, 1127, 10.1084/jem.179.4.1127

Parretta, 2008, Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2′-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow, Journal of Immunology, 180, 7230, 10.4049/jimmunol.180.11.7230

Rochman, 2009, New insights into the regulation of T cells by gamma(c) family cytokines, Nature Reviews Immunology, 9, 480, 10.1038/nri2580

Peschon, 1994, Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice, The Journal of Experimental Medicine, 180, 1955, 10.1084/jem.180.5.1955

von Freeden-Jeffry, 1995, Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine, The Journal of Experimental Medicine, 181, 1519, 10.1084/jem.181.4.1519

Surh, 2005, Regulation of mature T cell homeostasis, Seminars in Immunology, 17, 183, 10.1016/j.smim.2005.02.007

Jacobs, 2010, IL-7 is essential for homeostatic control of T cell metabolism in vivo, Journal of Immunology, 184, 3461, 10.4049/jimmunol.0902593

Fontenot, 2005, A function for interleukin 2 in Foxp3-expressing regulatory T cells, Nature Immunology, 6, 1142, 10.1038/ni1263

Bayer, 2007, Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells, Journal of Immunology, 178, 4062, 10.4049/jimmunol.178.7.4062

Burchill, 2007, IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells, Journal of Immunology, 178, 280, 10.4049/jimmunol.178.1.280

Bayer, 2008, A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells, Journal of Immunology, 181, 225, 10.4049/jimmunol.181.1.225

Mazzucchelli, 2008, Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP, Blood, 112, 3283, 10.1182/blood-2008-02-137414

Peffault de Latour, 2006, Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7, Blood, 108, 2300, 10.1182/blood-2006-04-017947

Feuerer, 2009, Foxp3+ regulatory T cells: differentiation, specification, subphenotypes, Nature Immunology, 10, 689, 10.1038/ni.1760

Li, 2011, IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-beta7-dependent localization, Journal of Autoimmunity, 37, 217, 10.1016/j.jaut.2011.06.002

Ernst, 1999, The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery, Immunity, 11, 173, 10.1016/S1074-7613(00)80092-8

Tan, 2002, Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells, The Journal of Experimental Medicine, 195, 1523, 10.1084/jem.20020066

Schluns, 2000, Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo, Nature Immunology, 1, 426, 10.1038/80868

Alves, 2009, Characterization of the thymic IL-7 niche in vivo, Proceedings of the National Academy of Sciences of the United States of America, 106, 1512, 10.1073/pnas.0809559106

Kim, 2011, Seeing is believing: illuminating the source of in vivo interleukin-7, Immune Network, 11, 1, 10.4110/in.2011.11.1.1

Link, 2007, Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells, Nature Immunology, 8, 1255, 10.1038/ni1513

Mazzucchelli, 2009, Visualization and identification of IL-7 producing cells in reporter mice, PLoS ONE, 4, e7637, 10.1371/journal.pone.0007637

Repass, 2009, IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells, Genesis, 47, 281, 10.1002/dvg.20497

Shalapour, 2010, Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo, European Journal of Immunology, 40, 2391, 10.1002/eji.201040441

Dai, 2001, Cutting edge: secondary lymphoid organs are essential for maintaining the CD4, but not CD8, naive T cell pool, Journal of Immunology, 167, 6711, 10.4049/jimmunol.167.12.6711

Dummer, 2001, Autologous regulation of naive T cell homeostasis within the T cell compartment, Journal of Immunology, 166, 2460, 10.4049/jimmunol.166.4.2460

Guimond, 2009, Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells, Nature Immunology, 10, 149, 10.1038/ni.1695

Martin, 2010, Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells?, Nature Immunology, 11, 548, 10.1038/ni0710-547

Tan, 2001, IL-7 is critical for homeostatic proliferation and survival of naive T cells, Proceedings of the National Academy of Sciences of the United States of America, 98, 8732, 10.1073/pnas.161126098

Cho, 2010, T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis, Immunity, 32, 214, 10.1016/j.immuni.2009.11.014

Barata, 2004, Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells, The Journal of Experimental Medicine, 200, 659, 10.1084/jem.20040789

Johnson, 2008, IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors, Journal of Immunology, 180, 8109, 10.4049/jimmunol.180.12.8109

Mazzucchelli, 2007, Interleukin-7 receptor expression: intelligent design, Nature Reviews Immunology, 7, 144, 10.1038/nri2023

Le Campion, 2002, Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes, Proceedings of the National Academy of Sciences of the United States of America, 99, 4538, 10.1073/pnas.062621699

Min, 2003, Neonates support lymphopenia-induced proliferation, Immunity, 18, 131, 10.1016/S1074-7613(02)00508-3

Swainson, 2007, IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway, Blood, 109, 1034, 10.1182/blood-2006-06-027912

Lali, 2004, A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation, Journal of Immunology, 172, 3527, 10.4049/jimmunol.172.6.3527

Osborne, 2007, Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice, The Journal of Experimental Medicine, 204, 619, 10.1084/jem.20061871

Chetoui, 2010, Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway, Immunology, 130, 418, 10.1111/j.1365-2567.2009.03244.x

Park, 2004, Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival, Immunity, 21, 289, 10.1016/j.immuni.2004.07.016

Palmer, 2011, Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naive CD8(+) T cells, Immunology and Cell Biology, 89, 581, 10.1038/icb.2011.5

Fruman, 2009, Fine tuning the immune response with PI3K, Immunological Reviews, 228, 253, 10.1111/j.1600-065X.2008.00750.x

Deane, 2007, T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling, Blood, 109, 2894, 10.1182/blood-2006-07-038620

Okkenhaug, 2002, Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice, Science, 297, 1031, 10.1126/science.1073560

Suzuki, 2000, Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c) Jak3, and gamma(c) and Jak3 double-deficient mice, International Immunology, 12, 123, 10.1093/intimm/12.2.123

Foxwell, 1995, Interleukin-7 can induce the activation of Jak 1 Jak 3 and STAT 5 proteins in murine T cells, European Journal of Immunology, 25, 3041, 10.1002/eji.1830251109

Jiang, 2005, Cell biology of IL-7, a key lymphotrophin, Cytokine & Growth Factor Reviews, 16, 513, 10.1016/j.cytogfr.2005.05.004

Rochman, 2010, Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling, Proceedings of the National Academy of Sciences of the United States of America, 107, 19455, 10.1073/pnas.1008271107

Yao, 2006, Stat5a/b are essential for normal lymphoid development and differentiation, Proceedings of the National Academy of Sciences of the United States of America, 103, 1000, 10.1073/pnas.0507350103

Seki, 2007, IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs, Journal of Immunology, 178, 262, 10.4049/jimmunol.178.1.262

Hand, 2010, Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival, Proceedings of the National Academy of Sciences of the United States of America, 107, 16601, 10.1073/pnas.1003457107

Tripathi, 2010, STAT5 is critical to maintain effector CD8+ T cell responses, Journal of Immunology, 185, 2116, 10.4049/jimmunol.1000842

Venkitaraman, 1994, Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor, European Journal of Immunology, 24, 2168, 10.1002/eji.1830240935

Dzhagalov, 2008, The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages, Journal of Immunology, 181, 521, 10.4049/jimmunol.181.1.521

Opferman, 2003, Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1, Nature, 426, 671, 10.1038/nature02067

Dunkle, 2010, Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2, Cell Death and Differentiation, 17, 994, 10.1038/cdd.2009.201

Khaled, 1999, Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH, Proceedings of the National Academy of Sciences of the United States of America, 96, 14476, 10.1073/pnas.96.25.14476

Li, 2004, Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival, The Journal of Biological Chemistry, 279, 29160, 10.1074/jbc.M401656200

Li, 2010, Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival, Molecular and Cellular Biology, 30, 590, 10.1128/MCB.01006-09

Buentke, 2006, Do CD8 effector cells need IL-7R expression to become resting memory cells?, Blood, 108, 1949, 10.1182/blood-2006-04-016857

Pearson, 2011, IL-7 determines homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo, European Journal of Immunology, 41, 3656, 10.1002/eji.201141514

Michalek, 2010, The metabolic life and times of a T-cell, Immunological Reviews, 236, 190, 10.1111/j.1600-065X.2010.00911.x

Rathmell, 2001, IL-7 enhances the survival and maintains the size of naive T cells, Journal of Immunology, 167, 6869, 10.4049/jimmunol.167.12.6869

Wofford, 2008, IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival, Blood, 111, 2101, 10.1182/blood-2007-06-096297

Loisel-Meyer, 2012, Glut1-mediated glucose transport regulates HIV infection, Proceedings of the National Academy of Sciences of the United States of America, 109, 2549, 10.1073/pnas.1121427109

Luo, 2011, Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling, The Journal of Biological Chemistry, 286, 41135, 10.1074/jbc.M111.302596

Luo, 2011, Ephrinb1 and Ephrinb2 are associated with interleukin-7 receptor alpha and retard its internalization from the cell surface, The Journal of Biological Chemistry, 286, 44976, 10.1074/jbc.M111.316414

Henriques, 2010, IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells, Blood, 115, 3269, 10.1182/blood-2009-10-246876

Hemar, 1995, Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains, The Journal of Cell Biology, 129, 55, 10.1083/jcb.129.1.55

Pua, 2007, A critical role for the autophagy gene Atg5 in T cell survival and proliferation, The Journal of Experimental Medicine, 204, 25, 10.1084/jem.20061303

Williams, 2007, The emerging shape of the ESCRT machinery, Nature Reviews Molecular Cell Biology, 8, 355, 10.1038/nrm2162

McLeod, 2011, The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Ralpha surface expression, Journal of Immunology, 187, 5051, 10.4049/jimmunol.1100710

Kaech, 2003, Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells, Nature Immunology, 4, 1191, 10.1038/ni1009

Klonowski, 2006, Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development, Journal of Immunology, 177, 4247, 10.4049/jimmunol.177.7.4247

Chandele, 2008, Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1, Journal of Immunology, 180, 5309, 10.4049/jimmunol.180.8.5309

Xue, 2004, GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells, Nature Immunology, 5, 1036, 10.1038/ni1117

Doan, 2003, Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment, Journal of Immunology, 170, 2356, 10.4049/jimmunol.170.5.2356

Guo, 2010, Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis, Proceedings of the National Academy of Sciences of the United States of America, 107, 18505, 10.1073/pnas.1010249107

Clements, 2006, Impaired generation of CD8+ thymocytes in Ets-1-deficient mice, Journal of Immunology, 177, 905, 10.4049/jimmunol.177.2.905

Grenningloh, 2011, Ets-1 maintains IL-7 receptor expression in peripheral T cells, Journal of Immunology, 186, 969, 10.4049/jimmunol.1002099

Kieper, 2005, Recent immune status determines the source of antigens that drive homeostatic T cell expansion, Journal of Immunology, 174, 3158, 10.4049/jimmunol.174.6.3158

Kerdiles, 2009, Foxo1 links homing and survival of naive T cells by regulating L-selectin CCR7 and interleukin 7 receptor, Nature Immunology, 10, 176, 10.1038/ni.1689

Ouyang, 2009, An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance, Immunity, 30, 358, 10.1016/j.immuni.2009.02.003

Gubbels Bupp, 2009, T cells require Foxo1 to populate the peripheral lymphoid organs, European Journal of Immunology, 39, 2991, 10.1002/eji.200939427

Fabre, 2008, FOXO1 regulates L-selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase, Journal of Immunology, 181, 2980, 10.4049/jimmunol.181.5.2980

Hedrick, 2009, The cunning little vixen: foxo and the cycle of life and death, Nature Immunology, 10, 1057, 10.1038/ni.1784

Smith, 2001, Sensory adaptation in naive peripheral CD4 T cells, The Journal of Experimental Medicine, 194, 1253, 10.1084/jem.194.9.1253

Kassiotis, 2003, Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells, The Journal of Experimental Medicine, 197, 1007, 10.1084/jem.20021812

Kieper, 2004, A role for TCR affinity in regulating naive T cell homeostasis, Journal of Immunology, 172, 40, 10.4049/jimmunol.172.1.40

Park, 2007, ‘Coreceptor tuning’: cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR, Nature Immunology, 8, 1049, 10.1038/ni1512

D'Souza, 2008, The Erk2 MAPK regulates CD8 T cell proliferation and survival, Journal of Immunology, 181, 7617, 10.4049/jimmunol.181.11.7617

Nekrasova, 2005, ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis, Journal of Immunology, 175, 2374, 10.4049/jimmunol.175.4.2374

Pages, 1999, Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice, Science, 286, 1374, 10.1126/science.286.5443.1374

Lapinski, 2011, A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells, Journal of Immunology, 187, 151, 10.4049/jimmunol.1100178

Katzman, 2011, Opposing functions of IL-2 and IL-7 in the regulation of immune responses, Cytokine, 56, 116, 10.1016/j.cyto.2011.07.005

Xue, 2002, IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes, Proceedings of the National Academy of Sciences of the United States of America, 99, 13759, 10.1073/pnas.212214999

Feng, 2011, Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells, Nature Immunology, 12, 544, 10.1038/ni.2034

Ouyang, 2010, Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells, Nature Immunology, 11, 618, 10.1038/ni.1884

Kerdiles, 2010, Foxo transcription factors control regulatory T cell development and function, Immunity, 33, 890, 10.1016/j.immuni.2010.12.002

Simeoni, 2005, The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions, Molecular and Cellular Biology, 25, 7557, 10.1128/MCB.25.17.7557-7568.2005

Posevitz, 2008, Regulation of T cell homeostasis by the transmembrane adaptor protein SIT, Journal of Immunology, 180, 1634, 10.4049/jimmunol.180.3.1634

Alves, 2008, Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling, Journal of Immunology, 180, 5201, 10.4049/jimmunol.180.8.5201

Zenatti, 2011, Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia, Nature Genetics, 43, 932, 10.1038/ng.924

Shinnakasu, 2008, Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation, The Journal of Biological Chemistry, 283, 28216, 10.1074/jbc.M804174200