IL-6 switches the differentiation of monocytes from dendritic cells to macrophages

Nature Immunology - Tập 1 Số 6 - Trang 510-514 - 2000
Pascale Chomarat1, Jacques Banchereau2, Jean Davoust2, Karolina Palucka3
1Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
2Baylor Institute for Immunology Research, Dallas, USA
3Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, 75204, TX, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271–296 (1991).

Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).

Banchereau, J. et al. Immunobiology of dendritic cells. Ann. Rev. Immunol. 8, 767–811 (2000).

Becker, S., Warren, M. K. & Haskill, S. Colony-stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures. J. Immunol. 139, 3703–3709 (1987).

Romani, N. et al. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83–93 (1994).

Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109–1118 (1994).

Zhou, L. J. & Tedder, T. F. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl Acad. Sci. USA 93, 2588–2592 (1996).

Palucka, K. A., Taquet, N., Sanchez-Chapuis, F. & Gluckman, J. C. Dendritic cells as the terminal stage of monocyte differentiation. J. Immunol. 160, 4587–4595 (1998).

Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M. & Muller, W. A. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282, 480–483 (1998).

Mekori, Y. A. & Metcalfe, D. D. Mast cells in innate immunity. Immunol. Rev. 173, 131–140 (2000).

Yamasaki, K. et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN-β2) receptor. Science 241, 825–828 (1988).

Hibi, M. et al. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63, 1149–1157 (1990).

Peters, M. et al. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the half-life of IL-6. J. Exp. Med. 183, 1399–1406 (1996).

Menetrier-Caux, C. et al. Inhibition of the differentiation of dendritic cells from CD34+ progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood 92, 4778–4791 (1998).

Mitani, H. et al. Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells. Br. J. Haematol. 109, 288–295 (2000).

Kopf, M. et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368, 339–342 (1994).

Ladel, C.H. et al. Lethal tuberculosis in interleukin-6-deficient mutant mice. Infect. Immun. 65, 4843–4849 (1997).

Tanaka, T. et al. Targeted disruption of the NF-IL6 gene disclosed its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80, 353–361 (1995).