IL-6/gp130 signaling: a key unlocking regeneration

Cell Regeneration - Tập 12 Số 1
Ruopu Li1, Deqiang Li2, Yu Nie1
1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Street, Beilishi Road, Xicheng District, 100037, Beijing, People’s Republic of China
2The Center for Cardiovascular Research, the Research Institute at Nationwide Children’s Hospital, 575 Children’s Drive, Columbus, OH, 43215, USA

Tóm tắt

AbstractLiver is an organ with notable capacity of regeneration. Reprogramming of hepatocytes towards an immature state is one of the important mechanisms for hepatocyte replenishment. Inflammatory response mediated by IL-6 and its family cytokines has been widely reported closely related with tissue regeneration in myriads of organs. Recently Hui and colleagues reported that the dedifferentiation of hepatocytes depends upon IL-6 signaling from Kupffer cells and the reprogramming of gene expression under the inflammatory condition is different from the regulation of gene expression during embryo hepatocyte specification, highlighting a tight linkage between extracellular microenvironment and parenchymal cell plasticity during tissue regenerative repair.

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Cell Regeneration

Tập 12 Số 1

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