IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma

Oncotarget - Tập 8 Số 7 - Trang 11228-11238 - 2017
Chunbao Zang1, Xujie Liu1, Bing Li2, Yanqiong He1, Shen Jing1, Yujia He1, Wen‐Li Wu1, Bingqian Zhang1, Shuhong Ma1, Weiwei Dai1, Shaolin Li1, Zhiping Peng1
1Department of Radiological Medicine, Chongqing Medical University, Chonging, China
2Department of Otorhinolaryngology, The First Affiliated Hospital of Chonqqing Medical University, Chongqing, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Wittekind, 2013, Multimodal treatment of esophageal cancer, Langenbeck's archives of surgery, 398, 177, 10.1007/s00423-012-1001-1

Tanaka, 2013, Epidemiology of esophageal cancer in Japan and China, Journal of epidemiology, 23, 233, 10.2188/jea.JE20120162

Sun, 1989, Ten-year follow-up of esophageal cancer treated by radical radiation therapy: analysis of 869 patients, International journal of radiation oncology, biology, physics, 16, 329, 10.1016/0360-3016(89)90324-6

Hay, 2005, The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it, Developmental dynamics, 233, 706, 10.1002/dvdy.20345

Moustakas, 2006, Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition, The Journal of cell biology, 174, 175, 10.1083/jcb.200512110

Thiery, 2002, Epithelial-mesenchymal transitions in tumour progression, Nature reviews Cancer, 2, 442, 10.1038/nrc822

Guo, 2011, Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition, International journal of radiation oncology, biology, physics, 81, 1530, 10.1016/j.ijrobp.2011.06.1956

Han, 1990, European journal of cancer, 43, 1214

Vooijs, 2011, E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells, Radiotherapy and oncology, 99, 392, 10.1016/j.radonc.2011.05.044

Teni, 2014, Raman spectroscopic study of radioresistant oral cancer sublines established by fractionated ionizing radiation, PloS one, 9, e97777, 10.1371/journal.pone.0097777

Karin, 2008, The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer, Trends in molecular medicine, 14, 109, 10.1016/j.molmed.2007.12.007

Hall, 2009, Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells, Oncogene, 28, 2940, 10.1038/onc.2009.180

Li, 2015, Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation, PloS one, 10, e0126149, 10.1371/journal.pone.0126149

Massague, 2008, TGFbeta in Cancer, Cell, 134, 215, 10.1016/j.cell.2008.07.001

Sleeman, 2006, Complex networks orchestrate epithelial-mesenchymal transitions, Nature reviews Molecular cell biology, 7, 131, 10.1038/nrm1835

Rossi, 2006, Cytokines in breast cancer, Cytokine & growth factor reviews, 17, 325, 10.1016/j.cytogfr.2006.07.002

Hall, 2007, Interleukin-6 is a potent growth factor for ER-alpha-positive human breast cancer, FASEB journal, 21, 3763, 10.1096/fj.07-8832com

Rose-John, 2015, The soluble interleukin-6 receptor and related proteins, Best practice & research Clinical endocrinology & metabolism, 29, 787, 10.1016/j.beem.2015.07.001

Febbraio, 2016, The role of gp130 receptor cytokines in the regulation of metabolic homeostasis, The Journal of experimental biology, 219, 259, 10.1242/jeb.129213

Resat, 2016, Constitutive activation of STAT3 in breast cancer cells: A review, International journal of cancer, 138, 2570, 10.1002/ijc.29923

Wang, 2008, Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function, The Journal of biological chemistry, 283, 14665, 10.1074/jbc.M707429200

Yamagishi, 2004, Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation, British journal of cancer, 91, 1543, 10.1038/sj.bjc.6602187

Kelsen, 2002, INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy, Journal of clinical oncology, 20, 1167, 10.1200/JCO.2002.20.5.1167

Wu, 2016, Fractionated irradiation-induced EMT-like phenotype conferred radioresistance in esophageal squamous cell carcinoma, Journal of radiation research

Sawitsky, 1965, The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia, Blood, 26, 642, 10.1182/blood.V26.5.642.642

Booth, 2002, Intestinal stem cells protect their genome by selective segregation of template DNA strands, Journal of cell science, 115, 2381, 10.1242/jcs.115.11.2381

Goodell, 2004, Molecular signatures of proliferation and quiescence in hematopoietic stem cells, PLoS biology, 2, e301, 10.1371/journal.pbio.0020301

Lippman, 2003, Targeting Bcl-2 and Bcl-XL with nonpeptidic small-molecule antagonists, Seminars in oncology, 30, 133, 10.1053/j.seminoncol.2003.08.015

Pantel, 2000, Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients, Journal of clinical oncology, 18, 80, 10.1200/JCO.2000.18.1.80

Dalton, 2009, Environment-mediated drug resistance: a major contributor to minimal residual disease, Nature reviews Cancer, 9, 665, 10.1038/nrc2714

Bloom, 1950, Acquired radioresistance of the crypt epithelium of the duodenum, Radiology, 55, 104, 10.1148/55.1.104

Hwang, 2012, Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53, Cancer biology & therapy, 13, 638, 10.4161/cbt.20081

Fukumoto, 2011, Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy, International journal of radiation oncology, biology, physics, 80, 540, 10.1016/j.ijrobp.2010.12.065

Li, 2015, The network of epithelial-mesenchymal transition: potential new targets for tumor resistance, Journal of cancer research and clinical oncology, 141, 1697, 10.1007/s00432-014-1840-y

Christofori, 2012, EMT as the ultimate survival mechanism of cancer cells, Seminars in cancer biology, 22, 194, 10.1016/j.semcancer.2012.02.013

Thiery, 2016, EMT 2016, Cell, 166, 21, 10.1016/j.cell.2016.06.028

Jung, 2016, Smad2/3-Regulated Expression of DLX2 Is Associated with Radiation-Induced Epithelial-Mesenchymal Transition and Radioresistance of A549 and MDA-MB-231 Human Cancer Cell Lines, PloS one, 11, e0147343, 10.1371/journal.pone.0147343

Russo, 2003, STAT proteins: from normal control of cellular events to tumorigenesis, Journal of cellular physiology, 197, 157, 10.1002/jcp.10364

Huang, 2004, Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines, Molecular cancer therapeutics, 3, 11, 10.1158/1535-7163.11.3.1

Inagaki, 2006, MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma, Clinical cancer research, 12, 3902, 10.1158/1078-0432.CCR-05-2376

Chiang, 2013, Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis, PloS one, 8, e69182, 10.1371/journal.pone.0069182

Wagner, 2013, Role of interleukin-1beta in radiation-enhancement of MDA-MB-231 breast cancer cell invasion, Radiation research, 180, 292, 10.1667/RR3240.1

Tanaka, 2002, Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023, Clinical cancer research, 8, 1223

Zeng, 2012, Stimulation of hepatoma cell invasiveness and metastatic potential by proteins secreted from irradiated nonparenchymal cells, International journal of radiation oncology, biology, physics, 84, 822, 10.1016/j.ijrobp.2012.01.011

Wick, 2001, Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma, Cancer research, 61, 2744