IL-4 in the Brain: A Cytokine To Remember

Journal of Immunology - Tập 189 Số 9 - Trang 4213-4219 - 2012
Sachin P. Gadani1,2, James C. Cronk1,2, Geoffrey T. Norris1, Jonathan Kipnis1,2
1*Department of Neuroscience and Graduate Program in Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA 22908; and
2†Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908

Tóm tắt

Abstract IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.

Từ khóa


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