IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells

Okamura, H., Tsutsui, H., Kashiwamura, S., Yoshimoto, T. and Nakanishi, K. 1998. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv. Immunol.70:281.

Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., Akita, K., Namba, M., Tanabe, F., Konishi, K., Fukuda, S. and Kurimoto, M. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature378:88.

Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., Kurimoto, M., Tanimoto, T., Flavell, R. A., Sato, V., Harding, M. W., Livingston, D. J. and Su, M. S. 1997. Activation of interferon-γ inducing factor mediated by interleukin- 1β converting enzyme. Science275:206.

Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., Torigoe, K., Tanimoto, T., Fukuda, S., Ikeda, M., Okamura, H. and Kurimoto, M. 1996. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol.156:4274.

Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., Fukuda, S. and Kurimoto, M. 1996. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur. J. Immunol.26:1647.

Kohno, K., Kataoka, J., Ohtsuki, T., Suemoto, Y., Okamoto, I., Usui, M., Ikeda, M. and Kurimoto, M. 1997. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol.158:1541.

Ahn, H. J., Maruo, S., Tomura, M., Mu, J., Hamaoka, T., Nakanishi, K., Clark, S., Kurimoto, M., Okamura, H. and Fujiwara, H. 1997. A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ. J. Immunol.159:2125.

Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F. and O'Garra, A. 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB. Immunity7:571.

Yoshimoto, T., Okamura, H., Tagawa, Y. I., Iwakura, Y. and Nakanishi, K. 1997. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc. Natl Acad. Sci. USA94:3948.

Tsutsui, H., Nakanishi, K., Matsui, K., Higashino, K., Okamura, H., Miyazawa, Y. and Kaneda, K. 1996. IFN-γ-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J. Immunol.157:3967.

Dao, T., Ohashi, K., Kayano, T., Kurimoto, M. and Okamura, H. 1996. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell. Immunol.173:230.

Tsutsui, H., Matsui, K., Kawada, N., Hyodo, Y., Hayashi, N., Okamura, H., Higashino, K. and Nakanishi, K. 1997. IL-18 accounts for both TNF-α- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. J. Immunol.159:3961.

Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K. and Akira, S. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity8:383.

Hyodo, Y., Matsui, K., Hayashi, N., Tsutsui, H., Kashiwamura, S.-I., Yamauchi, H., Hiroishi, K., Takeda, K., Tagawa, Y., Iwakura, Y., Kayagaki, N., Kurimoto, M., Okamura, H., Hada, T., Yagita, H., Akira, S., Nakanishi, K. and Higashino, K. 1999. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. J. Immunol.162:1662.

Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, S., Okamura, H., Akira, S. and Nakanishi, K. 1998. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol.161:3400.

Xu, D., Chan, W. L., Leung, B. P., Hunter, D., Schulz, K., Carter, R. W., McInnes, I. B., Robinson, J. H. and Liew, F. Y. 1998. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med.188:1485.

Kunikata, T., Torigoe, K., Ushio, S., Okura, T., Ushio, C., Yamauchi, H., Ikeda, M., Ikegami, H. and Kurimoto, M. 1998. Constitutive and induced IL-18 receptor expression by various peripheral blood cell subsets as determined by anti-hIL-18R monoclonal antibody. Cell. Immunol.189:135.

Durum, S. K., Schmidt, J. A. and Oppenheim, J. J. 1985. Interleukin 1: an immunological perspective. Adv. Immunol.3:261.

Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood87:2095.

Dinarello, C. A. 1999. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol.11:103.

Auron, P. E., Webb, A. C., Rosenwasser, L. J., Mucci, S. F., Rich, A., Wolff, S. M. and Dinarello, C. A. 1984. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl Acad. Sci. USA81:7907.

Matsushima, K., Taguchi, M., Kovacs, E. J., Young, H. A. and Oppenheim, J. J. 1986. Intracellular localization of human monocyte associated interleukin 1 (IL-1) activity and release of biologically active IL-1 from monocytes by trypsin and plasmin. J. Immunol.136:2883.

Wilson, K. P., Black, J. A., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A. and Livingston, D. J. 1994. Structure and mechanism of interleukin-1β converting enzyme. Nature370:270.

Bazan, J. F., Timans, J. C. and Kastelein, R. A. 1996. A newly defined interleukin-1? Nature379:591.

Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D. and Allen, H. 1997. Caspase-1 processes IFN-γ -inducing factor and regulates LPS-induced IFN-γ production. Nature386:619.

Parnet, P., Garka, K. E., Bonnert, T. P., Dower, S. K. and Sims, J. E. 1996. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J. Biol. Chem.271:3967.

Torigoe, K., Ushio, S., Okura, T., Kobayashi, S., Taniai, M., Kunikata, T., Murakami, T., Sanou, O., Kojima, H., Fujii, M., Ohta, T., Ikeda, M., Ikegami, H. and Kurimoto, M. 1997. Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem.272:25737.

Born, T. L., Thomassen, E., Bird, T. A. and Sims, J. E. 1998. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem.273:29445.

Sims, J. E., March, C. J., Cosman, D., Widmer, M. B., MacDonald, H. R., McMahan, C. J., Grubin, C. E., Wignal, J. M., Jackson, J. L. and Call, S. M. 1988. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science241:585.

Greenfeder, S. A., Nunes, P., Kwee, L., Labow, M., Chizzonite, R. A. and Ju, G. 1995. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem.270:13757.

Muzio, M., Ni, J., Feng, P. and Dixit, V. M. 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling. Science278:1612.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function. Immunity9:143.

Cao, Z., Henzel, W. J. and Gao, X. 1996. IRAK: a kinase associated with the interleukin-1 receptor. Science271:1128.

Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. and Goeddel, D. V. 1996. TRAF6 is a signal transducer for interleukin-1. Nature383:443.

Kojima, H., Takeuchi, M., Ohta, T., Nishida, Y., Arai, N., Ikeda, M., Ikegami, H. and Kurimoto, M. 1998. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. Biochem. Biophys. Res. Commun.244:183.

Matsumoto, S., Tsuji, T. K., Aizawa, Y., Koide, K., Takeuchi, M., Ohta, T. and Kurimoto, M. 1997. Interleukin-18 activates NF-κB in murine T helper type 1 cells. Biochem. Biophys. Res. Commun.234:454.

Barbulescu, K., Becker, C., Schlaak, J. F., Schmitt, E., Meyer zum Büschenfelde, K. H. and Neurath, M. F. 1998. Cutting edge: IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-γ promoter in primary CD4+ T lymphocytes. J. Immunol.160:3642.

Sica, A., Dorman, L., Viggiano, V., Cippitelli, M., Ghosh, P., Rice, N. and Young, H. A. 1997. Interaction of NF-κB and NFAT with the interferon-gamma promoter. J. Biol. Chem.272:30412.

Hunter, C. A., Chizzonite, R. and Remington, J. S. 1995. IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1β in the T cell-independent mechanism of resistance against intracellular pathogens. J. Immunol.155:4347.

Hunter, C. A., Timans, J., Pisacane, P., Menon, S., Cai, G., Walker, W., Aste, A. M., Chizzonite, R., Bazan, J. F. and Kastelein, R. A. 1997. Comparison of the effects of interleukin-1α, interleukin-1β and interferon-γ-inducing factor on the production of interferon- gamma by natural killer. Eur. J. Immunol.27:2787.

Skeen, M. J. and Ziegler, H. K. 1995. Activation of gamma delta T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J. Immunol.154:5832.

O'Garra, A. and Murphy, K. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol.6:458.

D'Andrea, A., Aste-Amezaga, M., Valiante, N. M., Ma, X., Kubin, M. and Trinchieri, G. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med.178:1041.

Sornasse, T., Larenas, P. V., Davis, K. A., de Vries, J. E. and Yssel, H. 1996. Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J. Exp. Med.184:473.

Rogge, L., Barberis, M. L., Biffi, M., Passini, N., Presky, D. H., Gubler, U. and Sinigaglia, F. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med.185:825.

King, P. D. and Katz, D. R. 1989. Human tonsillar dendritic cell-induced T cell responses: analysis of molecular mechanisms using monoclonal antibodies. Eur. J. Immunol.19:581.

Shau, H. and Golub, S. H. 1985. Depletion of NK cells with the lysosomotropic agent L-leucine methyl ester and the in vitro generation of NK activity from NK precursor cells. J. Immunol.134:1136.

Vikingsson, A., Pederson, K. and Muller, D. 1994. Enumeration of IFN-γ producing lymphocytes by flow cytometry and correlation with quantitative measurement of IFN-γ. J. Immunol. Methods173:219.

Yoshimoto, T. and Paul, W. E. 1994. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med.179:1285.

Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A. and Sinigaglia, F. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med.187:129.

Hoshino, K., Tsutsui, H., Kawai, T., Takeda, K., Nakanishi, K., Takeda, Y. and Akira, S. 1999. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol.162:5041.

Novick, D., Kim, S. H., Fantuzzi, G., Reznikov, L. L., Dinarello, C. A. and Rubinstein, M. 1999. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity.10:127.