IFNλ Stimulates MxA Production in Human Dermal Fibroblasts via a MAPK-Dependent STAT1-Independent Mechanism

Abushahba, 2010, Antitumor activity of type I and type III interferons in BNL hepatoma model, Cancer Immunol Immunother, 59, 1059, 10.1007/s00262-010-0831-3 Ank, 2008, An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity, J Immunol, 180, 2474, 10.4049/jimmunol.180.4.2474 Bachmann, 2013, IFNalpha converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets, Biochem Pharmacol, 85, 396, 10.1016/j.bcp.2012.11.004 Bolen, 2014, Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression, Hepatology, 59, 1262, 10.1002/hep.26657 Capaldo, 2012, IFN-gamma and TNF-alpha-induced GBP-1 inhibits epithelial cell proliferation through suppression of beta-catenin/TCF signaling, Mucosal Immunol, 5, 681, 10.1038/mi.2012.41 Chai, 2011, IL-29 and IFN-alpha regulate the expression of MxA, 2′,5′-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells, Mol Biol Rep, 38, 139, 10.1007/s11033-010-0087-1 Clark, 2003, Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38, FEBS Lett, 546, 37, 10.1016/S0014-5793(03)00439-3 Dai, 2009, IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells, Blood, 113, 5829, 10.1182/blood-2008-09-179507 Dickensheets, 2013, Interferon-lambda (IFN-lambda) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes, J Leukoc Biol, 93, 377, 10.1189/jlb.0812395 Duong, 2014, IFN-lambda receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-lambda3 genotype and with nonresponsiveness to IFN-alpha therapies, J Exp Med, 211, 857, 10.1084/jem.20131557 Egli, 2014, Immunomodulatory Function of Interleukin 28B during primary infection with cytomegalovirus, J Infect Dis, 210, 717, 10.1093/infdis/jiu144 Eickelberg, 2001, Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts, FASEB J, 15, 797, 10.1096/fj.00-0233com Ghosh, 2001, Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators, J Biol Chem, 276, 11041, 10.1074/jbc.M004709200 Goh, 1999, p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons, EMBO J, 18, 5601, 10.1093/emboj/18.20.5601 Gough, 2008, IFNgamma signaling-does it mean JAK-STAT?, Cytokine Growth Factor Rev, 19, 383, 10.1016/j.cytogfr.2008.08.004 Hasegawa, 2003, IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts, J Dermatol Sci, 32, 19, 10.1016/S0923-1811(03)00044-6 Heino, 2007, The collagen family members as cell adhesion proteins, BioEssays, 29, 1001, 10.1002/bies.20636 Joshi, 2010, Mechanisms of mRNA translation of interferon stimulated genes, Cytokine, 52, 123, 10.1016/j.cyto.2010.03.019 Kotenko, 2003, IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex, Nat Immunol, 4, 69, 10.1038/ni875 Lasfar, 2011, Interferon lambda: a new sword in cancer immunotherapy, Clin Dev Immunol, 2011, 349575, 10.1155/2011/349575 Li, 2004, Role of p38alpha Map kinase in Type I interferon signaling, J Biol Chem, 279, 970, 10.1074/jbc.M309927200 Liu, 2011, IL-29 and IFNalpha differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNgamma receptor expression, Blood, 117, 2385, 10.1182/blood-2010-07-298976 Lutfalla, 1995, Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster, EMBO J, 14, 5100, 10.1002/j.1460-2075.1995.tb00192.x MacMicking, 2012, Interferon-inducible effector mechanisms in cell-autonomous immunity, Nat Rev Immunol, 12, 367, 10.1038/nri3210 Maher, 2008, IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity, Cancer Biol Ther, 7, 1109, 10.4161/cbt.7.7.6192 Mennechet, 2006, Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells, Blood, 107, 4417, 10.1182/blood-2005-10-4129 Meyer, 2009, Interferons and autoimmune disorders, Joint Bone Spine, 76, 464, 10.1016/j.jbspin.2009.03.012 Miknis, 2010, Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1, J Mol Biol, 404, 650, 10.1016/j.jmb.2010.09.068 Naschberger, 2010, Increased expression of guanylate binding protein-1 in lesional skin of patients with cutaneous lupus erythematosus, Exp Dermatol, 20, 102, 10.1111/j.1600-0625.2010.01160.x Nguyen, 2000, Biochem J, 349, 427, 10.1042/bj3490427 Nyberg, 2000, Proliferation and effects of UVA irradiation in cultured fibroblasts from lesions in cutaneous lupus erythematosus, Exp Dermatol, 9, 53, 10.1034/j.1600-0625.2000.009001053.x Nystrom, 2013, Collagen VII plays a dual role in wound healing, J Clin Invest, 123, 3498, 10.1172/JCI68127 Oliveira, 2009, Hypertrophic versus non hypertrophic scars compared by immunohistochemistry and laser confocal microscopy: type I and III collagens, Int Wound J, 6, 445, 10.1111/j.1742-481X.2009.00638.x Platanias, 2003, The p38 mitogen-activated protein kinase pathway and its role in interferon signaling, Pharmacol Ther, 98, 129, 10.1016/S0163-7258(03)00016-0 Prokunina-Olsson, 2013, A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus, Nat Genet, 45, 164, 10.1038/ng.2521 Ronnblom, 2013, The interferon signature in autoimmune diseases, Curr Opin Rheumatol, 25, 248, 10.1097/BOR.0b013e32835c7e32 Sadler, 2008, Interferon-inducible antiviral effectors, Nat Rev Immunol, 8, 559, 10.1038/nri2314 Sheppard, 2003, IL-28, IL-29 and their class II cytokine receptor IL-28R, Nat Immunol, 4, 63, 10.1038/ni873 Sommereyns, 2008, IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo, PLoS Pathog, 4, e1000017, 10.1371/journal.ppat.1000017 Steen, 2010, Interferon-lambda as a potential therapeutic agent in cancer treatment, J Interferon Cytokine Res, 30, 597, 10.1089/jir.2010.0058 Uddin, 2000, The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins, J Biol Chem, 275, 27634, 10.1074/jbc.M003170200 van Boxel-Dezaire, 2006, Complex modulation of cell type-specific signaling in response to type I interferons, Immunity, 25, 361, 10.1016/j.immuni.2006.08.014 Wenzel, 2005, Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA, Br J Dermatol, 153, 1011, 10.1111/j.1365-2133.2005.06784.x Witte, 2009, Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines, Genes Immun, 10, 702, 10.1038/gene.2009.72 Witte, 2010, IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties, Cytokine Growth Factor Rev, 21, 237, 10.1016/j.cytogfr.2010.04.002 Wolk, 2013, IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis, Sci Transl Med, 5, 204ra129, 10.1126/scitranslmed.3006245 Xu, 2009, TGF-beta-induced epithelial to mesenchymal transition, Cell Res, 19, 156, 10.1038/cr.2009.5 Yin, 2012, Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells, J Immunol, 189, 2735, 10.4049/jimmunol.1102038 Zahn, 2011, Interferon-alpha stimulates TRAIL expression in human keratinocytes and peripheral blood mononuclear cells: implications for the pathogenesis of cutaneous lupus erythematosus, Br J Dermatol, 165, 1118, 10.1111/j.1365-2133.2011.10479.x Zahn, 2010, Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFNlambda) in cutaneous lupus erythematosus, J Investig Dermatol Symp Proc, 131, 133, 10.1038/jid.2010.244 Zitzmann, 2006, Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells, Biochem Biophys Res Commun, 344, 1334, 10.1016/j.bbrc.2006.04.043