ICI 182,780, a new antioestrogen with clinical potential

The Journal of Steroid Biochemistry and Molecular Biology - Tập 43 Số 1-3 - Trang 173-177 - 1992
Alan E. Wakeling1, Jean Bowler2
1Bioscience I and Chemistry I, Mereside Laboratories, Macclesfield, Cheshire, England.
2Bioscience I and Chemistry I, ICI Pharmaceuticals, Mereside Laboratories, Alderley Park, Macclesfield, Cheshire SK10 4TG, England

Tóm tắt

Từ khóa


Tài liệu tham khảo

Litherland, 1988, Antioestrogens in the management of hormone-dependent breast cancer, Cancer Treat. Rev., 15, 183, 10.1016/0305-7372(88)90002-3

1990, Vol. 1

Jordan, 1990, Endocrine pharmacology of antiestrogens as antitumour agents, Endocrine Rev., 11, 578, 10.1210/edrv-11-4-578

Wakeling, 1987, Steroidal pure antioestrogens, J. Endocr., 112, R7, 10.1677/joe.0.112R007

Wakeling, 1988, Biology and mode of action of pure antioestrogens, J. Steroid Biochem., 30, 141, 10.1016/0022-4731(88)90086-6

Bowler, 1989, Novel steroidal pure antiestrogens, Steroids, 54, 71, 10.1016/0039-128X(89)90076-7

Wakeling, 1990, Steroidal pure antiestrogens, 239

Wakeling, 1991, A potent specific antiestrogen with clinical potential, Cancer Res., 51, 3867

Wakeling, 1988, Novel antioestrogens without partial agonist activity, J. Steroid Biochem., 31, 645, 10.1016/0022-4731(88)90014-3

Katzenellenbogen, 1987, Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens, Cancer Res., 47, 4355

Wakeling, 1989, Effect of antioestrogens on the proliferation of MCF-7 human breast cancer cells, J. Molec. Endocr., 2, 225, 10.1677/jme.0.0020225

Stewart, 1990, Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells, J. Biol. Chem., 265, 21172, 10.1016/S0021-9258(17)45342-7

Gottardis, 1989, Inhibition of tamoxifen-stimulated growth of an MCF-7 tumour variant in athymic mice by novel steroidal antiestrogens, Cancer Res., 49, 4090

Gottardis, 1990, Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa 101) in athymic mice, Cancer Res., 50, 3189

Nicholson, 1990, Estrogen deprivation in breast cancer. Clinical, experimental and biological aspects, Ann. N.Y. Acad. Sci., 595, 316, 10.1111/j.1749-6632.1990.tb34305.x