IAVPGEVA, IAVPTGVA, and LPYP, three peptides from soy glycinin, modulate cholesterol metabolism in HepG2 cells through the activation of the LDLR-SREBP2 pathway

Abidi, 2005, Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine, Arteriosclerosis, Thrombosis, and Vascular Biology, 25, 2170, 10.1161/01.ATV.0000181761.16341.2b Arnoldi, 2015, The role of grain legumes in the prevention of hypercholesterolemia and hypertension, Critical Reviews in Plant Sciences, 34, 144, 10.1080/07352689.2014.897908 Baum, 1998, Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women, American Journal of Clinical Nutrition, 68, 545, 10.1093/ajcn/68.3.545 Braithwaite, 2014, Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: An overview, Journal of Functional Foods, 6, 82, 10.1016/j.jff.2013.09.022 Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis, Science, 232, 34, 10.1126/science.3513311 Brown, 1997, The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5 Brugger, 1996, Familial hypercholesterolemia and familial defective apolipoprotein B-100: Comparison of the phenotypic expression in 116 cases, European Journal of Medical Research, 1, 383 Cam, 2012, Role of dietary proteins and peptides in cardiovascular disease, Molecular Nutrition & Food Research, 56, 53, 10.1002/mnfr.201100535 Castoreno, 2005, Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins, Proceedings of the National Academy of Sciences of the United States of America, 102, 13129, 10.1073/pnas.0506716102 Chen, 2011, Role and classification of cholesterol-lowering functional foods, Journal of Functional Foods, 3, 61, 10.1016/j.jff.2011.02.003 Ching, 1996, Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method, European Journal of Biochemistry, 237, 800, 10.1111/j.1432-1033.1996.0800p.x Cho, 2008, Identification of LDL-receptor transcription stimulating peptides from soybean hydrolysate in human hepatocytes, Journal of Agricultural and Food Chemistry, 56, 4372, 10.1021/jf800676a Consonni, 2010, Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alpha’ subunit involved in Hep G2 cell cholesterol homeostasis, Journal of Nutritional Biochemistry, 21, 887, 10.1016/j.jnutbio.2009.07.003 Consonni, 2011, Heterologous expression and purification of the soybean 7S globulin alpha’ subunit extension region: In vitro evidence of its involvement in cell cholesterol homeostasis, Protein Expression and Purification, 80, 125, 10.1016/j.pep.2011.07.008 Dietschy, 1993, The interaction of dietary cholesterol and specific fatty acids in the regulation of LDL receptor activity and plasma LDL-cholesterol concentrations, Annals of the New York Academy of Sciences, 676, 11, 10.1111/j.1749-6632.1993.tb38722.x Duranti, 2004, The alpha’ subunit from soybean 7S globulin lowers plasma lipids and upregulates liver beta-VLDL receptors in rat feed a hypercholesterolemic diet, Journal of Nutrition, 134, 1334, 10.1093/jn/134.6.1334 Ferreira, 2010, beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet, Journal of Functional Foods, 2, 275, 10.1016/j.jff.2010.11.001 Fukui, 2002, Isoflavone-free soy protein prepared by column chromatography reduces plasma cholesterol in rats, Journal of Agricultural and Food Chemistry, 50, 5717, 10.1021/jf025642f Gianazza, 2003, A proteomic investigation of isolated soy proteins with variable effects in experimental and clinical studies, Journal of Nutrition, 133, 9, 10.1093/jn/133.1.9 Goldstein, 1990, Regulation of the mevalonate pathway, Nature, 343, 425, 10.1038/343425a0 Hardie, 2008, AMPK: A key regulator of energy balance in the single cell and the whole organism, International Journal of Obesity, 32, S7, 10.1038/ijo.2008.116 Harland, 2008, Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25 g soya protein per day and blood cholesterol, Atherosclerosis, 200, 13, 10.1016/j.atherosclerosis.2008.04.006 Horton, 1998, Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2, Journal of Clinical Investigation, 101, 2331, 10.1172/JCI2961 Hussain, 2001, Structural, biochemical and signaling properties of the low-density lipoprotein receptor gene family, Frontiers in Bioscience, 6, D417, 10.2741/Hussain1 Ishibashi, 1993, Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery, Journal of Clinical Investigation, 92, 883, 10.1172/JCI116663 Istvan, 2000, Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis, EMBO Journal, 19, 819, 10.1093/emboj/19.5.819 Jenkins, 2010, Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms, Journal of Nutrition, 140, 2302S, 10.3945/jn.110.124958 Kumar, 1998, Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1 beta- and tumor necrosis factor-alpha-induced low density lipoprotein receptor expression in HepG2 cells, Journal of Biological Chemistry, 273, 15742, 10.1074/jbc.273.25.15742 Lee, 2007, Berberine-induced LDLR up-regulation involves JNK pathway, Biochemical and Biophysical Research Communications, 362, 853, 10.1016/j.bbrc.2007.08.060 Li, 1999, Induction of low density lipoprotein receptor (LDLR) transcription by oncostatin M is mediated by the extracellular signal-regulated kinase signaling pathway and the repeat 3 element of the LDLR promoter, Journal of Biological Chemistry, 274, 6747, 10.1074/jbc.274.10.6747 Liu, 2014, Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: A 6-month randomized, double- blind, and placebo-controlled trial in equol-producing postmenopausal women, Molecular Nutrition & Food Research, 58, 709, 10.1002/mnfr.201300499 Lovati, 1987, Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients, Journal of Clinical Investigation, 80, 1498, 10.1172/JCI113232 Lu, 2008, Gossypin up-regulates LDL receptor through activation of ERK pathway: A signaling mechanism for the hypocholesterolemic effect, Journal of Agricultural and Food Chemistry, 56, 11526, 10.1021/jf802607x Marazza, 2013, Soymilk fermented with Lactobacillus rhamnosus CRL981 ameliorates hyperglycemia, lipid profiles and increases antioxidant enzyme activities in diabetic mice, Journal of Functional Foods, 5, 1848, 10.1016/j.jff.2013.09.005 Martinez-Villaluenga, 2009, Protein hydrolysates from beta-conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation in vitro, Molecular Nutrition & Food Research, 53, 1007, 10.1002/mnfr.200800473 Motoshima, 2006, AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer, Journal of Physiology-London, 574, 63, 10.1113/jphysiol.2006.108324 Nicholson, 1992, Transforming growth factor-beta up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells, Journal of Biological Chemistry, 267, 25982, 10.1016/S0021-9258(18)35705-3 Oliaro-Bosso, 2009, Regulation of HMGCoA reductase activity by policosanol and octacosadienol, a new synthetic analogue of octacosanol, Lipids, 44, 907, 10.1007/s11745-009-3338-y Pak, 2012, Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase, Amino Acids, 43, 2015, 10.1007/s00726-012-1276-0 Pak, 2005, Isolation and identification of peptides from soy 11S-globulin with hypocholesterolemic activity, Chemistry of Natural Compounds, 41, 710, 10.1007/s10600-006-0017-6 Pallottini, 2005, 3-Hydroxy-3-methylglutaryl coenzyme A reductase deregulation and age-related hypercholesterolemia: A new role for ROS, Mechanisms of Ageing and Development, 126, 845, 10.1016/j.mad.2005.02.009 Scicchitano, 2014, Nutraceuticals and dyslipidaemia: Beyond the common therapeutics, Journal of Functional Foods, 6, 11, 10.1016/j.jff.2013.12.006 Sirtori, 1977, Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia, Lancet, 1, 275, 10.1016/S0140-6736(77)91823-2 Sirtori, 2005, Phytoestrogens: End of a tale?, Annals of Medicine, 37, 423, 10.1080/07853890510044586 Sirtori, 2007, Hypocholesterolaemic effects of soya proteins: Results of recent studies are predictable from the Anderson meta-analysis data, British Journal of Nutrition, 97, 816, 10.1017/S0007114507670810 Sirtori, 1984, Effects of dietary proteins on the regulation of liver lipoprotein receptors in rats, The Journal of Nutrition, 114, 1493, 10.1093/jn/114.8.1493 Sun, 2006, Statins activate AMP-activated protein kinase in vitro and in vivo, Circulation, 114, 2655, 10.1161/CIRCULATIONAHA.106.630194 Vargas, 2009, Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells, Journal of Lipid Research, 50, 386, 10.1194/jlr.M800316-JLR200 Vermeirssen, 2004, Bioavailability of angiotensin I converting enzyme inhibitory peptides, British Journal of Nutrition, 92, 357, 10.1079/BJN20041189 Wang, 2010, Chronic alcohol consumption disrupted cholesterol homeostasis in rats: Down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver, Alcoholism, Clinical and Experimental Research, 34, 471, 10.1111/j.1530-0277.2009.01111.x Yashiro, 2012, Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins, Atherosclerosis, 220, 369, 10.1016/j.atherosclerosis.2011.11.006 Yashiro, 2013, 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element, Atherosclerosis, 226, 95, 10.1016/j.atherosclerosis.2012.09.033 Zhou, 2014, Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells, Fitoterapia, 92, 230, 10.1016/j.fitote.2013.11.010