Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

Cell Reports - Tập 39 - Trang 110752 - 2022
Vivian Morris1, Dahai Wang2, Zhiheng Li2, William Marion1, Travis Hughes3,4,5, Patricia Sousa1, Taku Harada6, Shannan Ho Sui7, Sergey Naumenko7, Jérémie Kalfon4, Prerana Sensharma1,2, Marcelo Falchetti8, Renan Vinicius da Silva8, Tito Candelli9, Pauline Schneider9, Thanasis Margaritis9, Frank C.P. Holstege9, Yana Pikman5,6, Marian Harris5,10, Ronald W. Stam9
1Stem Cell Program, Boston Children’s Hospital, Boston, MA 02115, USA
2Stem Cell Transplantation Program, Department of Hematology, Boston Children’s Hospital, Boston, MA 02115, USA
3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5Harvard Medical School, Boston, MA 02115, USA
6Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children’s Hospital, Boston, MA 02115, USA
7Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
8Graduate Program of Pharmacology, Center for Biological Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil
9Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
10Department of Pathology, Boston Children’s Hospital, Boston, MA 02115, USA

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