Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Clinical and Translational Radiation Oncology - Tập 15 - Trang 62-69 - 2019
Linda Spiegelberg1, Ruud Houben2, Raymon Niemans1, Dirk de Ruysscher2, Ala Yaromina1, Jan Theys1, Christopher P. Guise3,4, Jeffrey B. Smaill3,4, Adam V. Patterson3,4, Philippe Lambin1, Ludwig J. Dubois1
1Department of Precision Medicine, The M-Lab, GROW – School for Oncology and Developmental Biology, Maastricht Comprehensive Cancer Centre, Maastricht University Medical Centre, Maastricht, The Netherlands
2Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands
3Translational Therapeutics Team, Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland, New Zealand
4Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland, New Zealand

Tài liệu tham khảo

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