Hypoxia-Inducible Factors and the Response to Hypoxic Stress

Adams, 2007, Nonalcoholic fatty liver disease, Ann. Epidemiol., 17, 863, 10.1016/j.annepidem.2007.05.013

Aghili, 2009, Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review, J. Neurooncol., 91, 233, 10.1007/s11060-008-9706-2

An, 1998, Stabilization of wild-type p53 by hypoxia-inducible factor 1, Nature, 392, 405, 10.1038/32925

Aragones, 2008, Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism, Nat. Genet., 40, 170, 10.1038/ng.2007.62

Arany, 2008, HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α, Nature, 451, 1008, 10.1038/nature06613

Bakker, 2007, FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2, Mol. Cell, 28, 941, 10.1016/j.molcel.2007.10.035

Baranova, 2007, Neuron-specific inactivation of the hypoxia inducible factor 1{alpha} increases brain injury in a mouse model of transient focal cerebral ischemia, J. Neurosci., 27, 6320, 10.1523/JNEUROSCI.0449-07.2007

Basner, 2007, Continuous positive airway pressure for obstructive sleep apnea, N. Engl. J. Med., 356, 1751, 10.1056/NEJMct066953

Beall, 2010, Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders, Proc. Natl. Acad. Sci. USA, 107, 11459, 10.1073/pnas.1002443107

Beckman, 2002, Diabetes and atherosclerosis: epidemiology, pathophysiology, and management, JAMA, 287, 2570, 10.1001/jama.287.19.2570

Bernardi, 2006, PML inhibits HIF-1[alpha] translation and neoangiogenesis through repression of mTOR, Nature, 442, 779, 10.1038/nature05029

Bertout, 2008, The impact of O2 availability on human cancer, Nat. Rev. Cancer, 8, 967, 10.1038/nrc2540

Bertout, 2009, HIF2 inhibition promotes p53 pathway activity, tumor cell death, and radiation responses, Proc. Natl. Acad. Sci. USA, 106, 14391, 10.1073/pnas.0907357106

Blagosklonny, 1998, p53 inhibits hypoxia-inducible factor-stimulated transcription, J. Biol. Chem., 273, 11995, 10.1074/jbc.273.20.11995

Bommi-Reddy, 2008, Kinase requirements in human cells: III. Altered kinase requirements in VHL−/− cancer cells detected in a pilot synthetic lethal screen, Proc. Natl. Acad. Sci. USA, 105, 16484, 10.1073/pnas.0806574105

Bosch-Marce, 2007, Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia, Circ. Res., 101, 1310, 10.1161/CIRCRESAHA.107.153346

Bostrom, 2006, Hypoxia converts human macrophages into triglyceride-loaded foam cells, Arterioscler. Thromb. Vasc. Biol., 26, 1871, 10.1161/01.ATV.0000229665.78997.0b

Botusan, 2008, Stabilization of HIF-1α is critical to improve wound healing in diabetic mice, Proc. Natl. Acad. Sci. USA, 105, 19426, 10.1073/pnas.0805230105

Boutin, 2008, Epidermal sensing of oxygen is essential for systemic hypoxic response, Cell, 133, 223, 10.1016/j.cell.2008.02.038

Brugarolas, 2004, Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes, Cancer Cell, 6, 7, 10.1016/j.ccr.2004.06.020

Buchberger, 2010, Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms, Mol. Cell, 40, 238, 10.1016/j.molcel.2010.10.001

Calabrese, 2007, A perivascular niche for brain tumor stem cells, Cancer Cell, 11, 69, 10.1016/j.ccr.2006.11.020

Carbia-Nagashima, 2007, RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1[alpha] during hypoxia, Cell, 131, 309, 10.1016/j.cell.2007.07.044

Carmeliet, 2005, Angiogenesis in life, disease and medicine, Nature, 438, 932, 10.1038/nature04478

Chan, 2009, Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment, Cancer Cell, 15, 527, 10.1016/j.ccr.2009.04.010

Cheng, 2007, SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia, Cell, 131, 584, 10.1016/j.cell.2007.08.045

Covello, 2004, HIFs, hypoxia, and vascular development, Curr. Top. Dev. Biol., 62, 37, 10.1016/S0070-2153(04)62002-3

Cramer, 2003, HIF-1[alpha] is essential for myeloid cell-mediated inflammation, Cell, 112, 645, 10.1016/S0092-8674(03)00154-5

Cummins, 2006, Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity, Proc. Natl. Acad. Sci. USA, 103, 18154, 10.1073/pnas.0602235103

Dang, 2009, Cancer-associated IDH1 mutations produce 2-hydroxyglutarate, Nature, 462, 739, 10.1038/nature08617

Denu, 2003, Linking chromatin function with metabolic networks: Sir2 family of NAD+-dependent deacetylases, Trends Biochem. Sci., 28, 41, 10.1016/S0968-0004(02)00005-1

Dioum, 2008, HIF-2-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery, Invest. Ophthalmol. Vis. Sci., 49, 2714, 10.1167/iovs.07-1469

Dioum, 2009, Regulation of hypoxia-inducible factor 2 signaling by the stress-responsive deacetylase sirtuin 1, Science, 324, 1289, 10.1126/science.1169956

Du, 2008, HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion, Cancer Cell, 13, 206, 10.1016/j.ccr.2008.01.034

Elvert, 2003, Cooperative interaction of hypoxia-inducible factor-2α (HIF-2α) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1), J. Biol. Chem., 278, 7520, 10.1074/jbc.M211298200

Ema, 1997, A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development, Proc. Natl. Acad. Sci. USA, 94, 4273, 10.1073/pnas.94.9.4273

Erler, 2009, Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche, Cancer Cell, 15, 35, 10.1016/j.ccr.2008.11.012

Fandrey, 2004, Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression, Am. J. Physiol. Regul. Integr. Comp. Physiol., 286, R977, 10.1152/ajpregu.00577.2003

Fang, 2009, Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia, Blood, 114, 844, 10.1182/blood-2008-12-195941

Franovic, 2009, Human cancers converge at the HIF-2 oncogenic axis, Proc. Natl. Acad. Sci. USA, 106, 21306, 10.1073/pnas.0906432106

Frede, 2006, Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB, Biochem. J., 396, 517, 10.1042/BJ20051839

Furlow, 2009, Erythrocytosis-associated HIF-2α mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline, J. Biol. Chem., 284, 9050, 10.1074/jbc.M808737200

Gerald, 2004, JunD reduces tumor angiogenesis by protecting cells from oxidative stress, Cell, 118, 781, 10.1016/j.cell.2004.08.025

Gnarra, 1997, Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice, Proc. Natl. Acad. Sci. USA, 94, 9102, 10.1073/pnas.94.17.9102

Gordan, 2007, HIF-2[alpha] promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity, Cancer Cell, 11, 335, 10.1016/j.ccr.2007.02.006

Gordan, 2007, HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation, Cancer Cell, 12, 108, 10.1016/j.ccr.2007.07.006

Gordan, 2008, HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma, Cancer Cell, 14, 435, 10.1016/j.ccr.2008.10.016

Greenberger, 2008, A RNA antagonist of hypoxia-inducible factor-1, EZN-2968, inhibits tumor cell growth, Mol. Cancer Ther., 7, 3598, 10.1158/1535-7163.MCT-08-0510

Gross, 2010, Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations, J. Exp. Med., 207, 339, 10.1084/jem.20092506

Haigis, 2010, Mammalian sirtuins: biological insights and disease relevance, Annu. Rev. Pathol., 5, 253, 10.1146/annurev.pathol.4.110807.092250

Heinl-Green, 2005, The efficacy of a ‘master switch gene’ HIF-1α in a porcine model of chronic myocardial ischaemia, Eur. Heart J., 26, 1327, 10.1093/eurheartj/ehi223

Helton, 2005, Brain-specific knock-out of hypoxia-inducible factor-1{alpha} reduces rather than increases hypoxic-ischemic damage, J. Neurosci., 25, 4099, 10.1523/JNEUROSCI.4555-04.2005

Herr, 2009, The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1{alpha} in macrophages via sphingosine-1-phosphate and transforming growth factor-{beta}, Blood, 114, 2140, 10.1182/blood-2009-01-201889

Hu, 2003, Differential roles of hypoxia-inducible factor 1{alpha} (HIF-1{alpha}) and HIF-2{alpha} in hypoxic gene regulation, Mol. Cell. Biol., 23, 9361, 10.1128/MCB.23.24.9361-9374.2003

Huang, 2002, Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-α ligands, glucocorticoids, and insulin, Diabetes, 51, 276, 10.2337/diabetes.51.2.276

Huang, 2009, Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation, Mol. Cell, 35, 856, 10.1016/j.molcel.2009.09.006

Huss, 2001, Hypoxia inhibits the peroxisome proliferator-activated receptor α/ retinoid X receptor gene regulatory pathway in cardiac myocytes, J. Biol. Chem., 276, 27605, 10.1074/jbc.M100277200

Imtiyaz, 2010, Hypoxia inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation, J. Clin. Invest., 120, 2699, 10.1172/JCI39506

Isaacs, 2002, Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway, J. Biol. Chem., 277, 29936, 10.1074/jbc.M204733200

Jain, 2005, Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy, Science, 307, 58, 10.1126/science.1104819

Jantsch, 2008, Hypoxia and hypoxia-inducible factor-1{alpha} modulate lipopolysaccharide-induced dendritic cell activation and function, J. Immunol., 180, 4697, 10.4049/jimmunol.180.7.4697

Jiang, 2009, Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF, J. Cell. Physiol., 218, 66, 10.1002/jcp.21566

Jungermann, 1988, Metabolic zonation of liver parenchyma, Semin. Liver Dis., 8, 329, 10.1055/s-2008-1040554

Kaelin, 2005, ROS: really involved in oxygen sensing, Cell Metab., 1, 357, 10.1016/j.cmet.2005.05.006

Kaelin, 2008, The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer, Nat. Rev. Cancer, 8, 865, 10.1038/nrc2502

Kaelin, 2008, Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway, Mol. Cell, 30, 393, 10.1016/j.molcel.2008.04.009

Kaidi, 2007, Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia, Nat. Cell Biol., 9, 210, 10.1038/ncb1534

Kajiwara, 2009, A hypoxic inducible factor-1alpha hybrid enhances collateral development and reduces vascular leakage in diabetic rats, J. Gene Med., 11, 390, 10.1002/jgm.1318

Kawanaka, 2008, Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy, J. Med. Invest., 55, 78, 10.2152/jmi.55.78

Keith, 2007, Hypoxia-inducible factors, stem cells, and cancer, Cell, 129, 465, 10.1016/j.cell.2007.04.019

Kelly, 2003, Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1, Circ. Res., 93, 1074, 10.1161/01.RES.0000102937.50486.1B

Kim, 2009, HIF2α cooperates with RAS to promote lung tumorigenesis in mice, J. Clin. Invest., 119, 2160, 10.1172/JCI38443

King, 2006, Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer, Oncogene, 25, 4675, 10.1038/sj.onc.1209594

Klimova, 2008, Mitochondrial complex III regulates hypoxic activation of HIF, Cell Death Differ., 15, 660, 10.1038/sj.cdd.4402307

Lee, 2008, Genetic causes of erythrocytosis and the oxygen-sensing pathway, Blood Rev., 22, 321, 10.1016/j.blre.2008.04.003

Lee, 2009, Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells, Proc. Natl. Acad. Sci. USA, 106, 2353, 10.1073/pnas.0812801106

Lee, 2009, Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization, Proc. Natl. Acad. Sci. USA, 106, 17910, 10.1073/pnas.0909353106

Lee, 2010, Negative regulation of hypoxic responses via induced reptin methylation, Mol. Cell, 39, 71, 10.1016/j.molcel.2010.06.008

Leek, 2002, Relation of hypoxia-inducible factor-2{alpha} (HIF-2{alpha}) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer, Cancer Res., 62, 1326

Lewis, 2006, Distinct role of macrophages in different tumor microenvironments, Cancer Res., 66, 605, 10.1158/0008-5472.CAN-05-4005

Li, 2009, Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells, Cancer Cell, 15, 501, 10.1016/j.ccr.2009.03.018

Lim, 2010, Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1, Mol. Cell, 38, 864, 10.1016/j.molcel.2010.05.023

Liu, 2008, Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells, J. Cell. Physiol., 217, 319, 10.1002/jcp.21503

Luo, 2009, Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1 but not HIF-2, J. Biol. Chem., 285, 3651, 10.1074/jbc.M109.068577

Mace, 2007, Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair, Wound Repair Regen., 15, 636, 10.1111/j.1524-475X.2007.00278.x

Mahon, 2001, FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity, Genes Dev., 15, 2675, 10.1101/gad.924501

Mak, 2010, ERβ impedes prostate cancer EMT by destabilizing HIF-1α and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading, Cancer Cell, 17, 319, 10.1016/j.ccr.2010.02.030

Manalo, 2005, Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1, Blood, 105, 659, 10.1182/blood-2004-07-2958

Maynard, 2007, Dominant-negative HIF-3α4 suppresses VHL-null renal cell carcinoma progression, Cell Cycle, 6, 2810, 10.4161/cc.6.22.4947

Mazumdar, 2010, HIF-2alpha deletion promotes Kras-driven lung tumor development, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1001296107

Mazzone, 2009, Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization, Cell, 136, 839, 10.1016/j.cell.2009.01.020

Moeller, 2005, Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity, Cancer Cell, 8, 99, 10.1016/j.ccr.2005.06.016

Mole, 2009, Genome-wide association of hypoxia-inducible factor (HIF)-1 and HIF-2 DNA binding with expression profiling of hypoxia-inducible transcripts, J. Biol. Chem., 284, 16767, 10.1074/jbc.M901790200

Mottet, 2003, Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β pathway in HepG2 cells, J. Biol. Chem., 278, 31277, 10.1074/jbc.M300763200

Muoio, 2007, Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease, Appl. Physiol. Nutr. Metab., 32, 874, 10.1139/H07-083

Murdoch, 2004, Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues, Blood, 104, 2224, 10.1182/blood-2004-03-1109

Nanduri, 2009, Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities, Proc. Natl. Acad. Sci. USA, 106, 1199, 10.1073/pnas.0811018106

Nizet, 2009, Interdependence of hypoxic and innate immune responses, Nat. Rev. Immunol., 9, 609, 10.1038/nri2607

Patnaik, 2009, EZN-2968, a novel hypoxia-inducible factor-1{alpha} (HIF-1{alpha}) messenger ribonucleic acid (mRNA) antagonist: results of a phase I, pharmacokinetic (PK), dose-escalation study of daily administration in patients (pts) with advanced malignancies, J. Clin. Oncol., 27, 2564, 10.1200/jco.2009.27.15_suppl.2564

Peng, 2006, Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia, J. Physiol., 577, 705, 10.1113/jphysiol.2006.114033

Peyssonnaux, 2005, HIF-1α expression regulates the bactericidal capacity of phagocytes, J. Clin. Invest., 115, 1806, 10.1172/JCI23865

Peyssonnaux, 2007, Cutting edge: essential role of hypoxia inducible factor-1{alpha} in development of lipopolysaccharide-induced sepsis, J. Immunol., 178, 7516, 10.4049/jimmunol.178.12.7516

Picard, 2002, PPARγ and glucose homeostasis, Annu. Rev. Nutr., 22, 167, 10.1146/annurev.nutr.22.010402.102808

Pietras, 2009, HIF-2 maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells, Proc. Natl. Acad. Sci. USA, 106, 16805, 10.1073/pnas.0904606106

Qi, 2010, Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors, Cancer Cell, 18, 23, 10.1016/j.ccr.2010.05.024

Rajagopalan, 2007, Use of a constitutively active hypoxia-inducible factor-1{alpha} transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience, Circulation, 115, 1234, 10.1161/CIRCULATIONAHA.106.607994

Ramirez-Bergeron, 2006, HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature, Dev. Cell, 11, 81, 10.1016/j.devcel.2006.04.018

Rankin, 2009, Hypoxia-inducible factor 2 regulates hepatic lipid metabolism, Mol. Cell. Biol., 29, 4527, 10.1128/MCB.00200-09

Ratan, 2007, Harnessing hypoxic adaptation to prevent, treat, and repair stroke, J. Mol. Med., 85, 1331, 10.1007/s00109-007-0283-1

Raval, 2005, Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma, Mol. Cell. Biol., 25, 5675, 10.1128/MCB.25.13.5675-5686.2005

Ravi, 2000, Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α, Genes Dev., 14, 34, 10.1101/gad.14.1.34

Rey, 2009, Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia, Proc. Natl. Acad. Sci. USA, 106, 20399, 10.1073/pnas.0911921106

Rius, 2008, NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α, Nature, 453, 807, 10.1038/nature06905

Roberts, 2009, Suppression of hypoxia-inducible factor 2{alpha} restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells, Cancer Res., 69, 9056, 10.1158/0008-5472.CAN-09-1770

Sanchez, 2007, Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency, Nat. Struct. Mol. Biol., 14, 420, 10.1038/nsmb1222

Sano, 2007, p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload, Nature, 446, 444, 10.1038/nature05602

Sarkar, 2009, Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice, Proc. Natl. Acad. Sci. USA, 106, 18769, 10.1073/pnas.0910561106

Schmid, 2004, p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1), Biochem. J., 380, 289, 10.1042/bj20031299

Schneider, 2010, Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury, Gastroenterology, 138, 1143, 10.1053/j.gastro.2009.09.057

Semenza, 2007, Evaluation of HIF-1 inhibitors as anticancer agents, Drug Discov. Today, 12, 853, 10.1016/j.drudis.2007.08.006

Sendoel, 2010, HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase, Nature, 465, 577, 10.1038/nature09141

Sengupta, 2010, Regulation of the mTor complex 1 by nutrients, growth factors and stress, Mol. Cell, 40, 310, 10.1016/j.molcel.2010.09.026

Shatrov, 2003, Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1{alpha} (HIF-1{alpha}) accumulation via redox-dependent mechanisms, Blood, 101, 4847, 10.1182/blood-2002-09-2711

Shohet, 2007, Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia, J. Mol. Med., 85, 1309, 10.1007/s00109-007-0279-x

Simon, 2004, Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia, Cell, 117, 851, 10.1016/j.cell.2004.06.010

Simon, 2006, Coming up for air: HIF-1 and mitochondrial oxygen consumption, Cell Metab., 3, 150, 10.1016/j.cmet.2006.02.007

Simonson, 2010, Genetic evidence for high-altitude adaptation in Tibet, Science, 329, 72, 10.1126/science.1189406

Skuli, 2009, Endothelial deletion of hypoxia-inducible factor-2{alpha} (HIF-2{alpha}) alters vascular function and tumor angiogenesis, Blood, 114, 469, 10.1182/blood-2008-12-193581

Spriggs, 2010, Translational regulation of gene expression during conditions of cell stress, Mol. Cell, 40, 228, 10.1016/j.molcel.2010.09.028

Stockmann, 2008, Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis, Nature, 456, 814, 10.1038/nature07445

Sudarshan, 2009, Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1{alpha} stabilization by glucose-dependent generation of reactive oxygen species, Mol. Cell. Biol., 29, 4080, 10.1128/MCB.00483-09

Taguchi, 2008, Identification of hypoxia-inducible factor-1 as a novel target for miR-17-92 microrna cluster, Cancer Res., 68, 5540, 10.1158/0008-5472.CAN-07-6460

Takeda, 2006, Placental but not heart defects are associated with elevated hypoxia-inducible factor {alpha} levels in mice lacking prolyl hydroxylase domain protein 2, Mol. Cell. Biol., 26, 8336, 10.1128/MCB.00425-06

Takeda, 2010, Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis, Genes Dev., 24, 491, 10.1101/gad.1881410

Tang, 2004, Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis, Cancer Cell, 6, 485, 10.1016/j.ccr.2004.09.026

Thieu, 2007, IL-4-stimulated NF-{kappa}B activity is required for Stat6 DNA binding, J. Leukoc. Biol., 82, 370, 10.1189/jlb.1106707

Tong, 2009, The molecular determinants of de novo nucleotide biosynthesis in cancer cells, Curr. Opin. Genet. Dev., 19, 32, 10.1016/j.gde.2009.01.002

Towler, 2007, AMP-activated protein kinase in metabolic control and insulin signaling, Circ. Res., 100, 328, 10.1161/01.RES.0000256090.42690.05

Turcotte, 2008, A molecule targeting vhl-deficient renal cell carcinoma that induces autophagy, Cancer Cell, 14, 90, 10.1016/j.ccr.2008.06.004

van de Sluis, 2009, COMMD1 promotes pVHL and O2-independent proteolysis of HIF-1α via HSP90/70, PLoS ONE, 4, e7332, 10.1371/journal.pone.0007332

van de Sluis, 2010, COMMD1 disrupts HIF-1α/β dimerization and inhibits human tumor cell invasion, J. Clin. Invest., 120, 2119, 10.1172/JCI40583

Vincent, 2000, Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked dna encoding an HIF-1{alpha}/VP16 hybrid transcription factor, Circulation, 102, 2255, 10.1161/01.CIR.102.18.2255

Walmsley, 2006, Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis, Blood, 108, 3176, 10.1182/blood-2006-04-018796

Ward, 2010, The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting [alpha]-ketoglutarate to 2-hydroxyglutarate, Cancer Cell, 17, 225, 10.1016/j.ccr.2010.01.020

Waypa, 2010, Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells, Circ. Res., 106, 526, 10.1161/CIRCRESAHA.109.206334

Webb, 2009, Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing, Cell. Mol. Life Sci., 66, 3539, 10.1007/s00018-009-0147-7

Webb, 2009, MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH), Biochem. J., 420, 327, 10.1042/BJ20081905

Weidemann, 2009, The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice, J. Clin. Invest., 119, 3373

Werno, 2010, Knockout of Hif-1alpha in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses, Carcinogenesis., 10.1093/carcin/bgq088

Whitmer, 1978, Control of fatty acid metabolism in ischemic and hypoxic hearts, J. Biol. Chem., 253, 4305, 10.1016/S0021-9258(17)34720-8

Wouters, 2008, Hypoxia signalling through mTOR and the unfolded protein response in cancer, Nat. Rev. Cancer, 8, 851, 10.1038/nrc2501

Xia, 2009, Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis, Proc. Natl. Acad. Sci. USA, 106, 4260, 10.1073/pnas.0810067106

Yamakawa, 2003, Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors, Circ. Res., 93, 664, 10.1161/01.RES.0000093984.48643.D7

Yamakuchi, 2010, P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis, Proc. Natl. Acad. Sci. USA, 107, 6334, 10.1073/pnas.0911082107

Yang, 2008, Direct regulation of TWIST by HIF-1[alpha] promotes metastasis, Nat. Cell Biol., 10, 295, 10.1038/ncb1691

Yi, 2010, Sequencing of 50 human exomes reveals adaptation to high altitude, Science, 329, 75, 10.1126/science.1190371

Yoshida, 2009, Hypoxia enhances the generation of induced pluripotent stem cells, Cell Stem Cell, 5, 237, 10.1016/j.stem.2009.08.001

Yoshida, 2010, Digoxin inhibits retinal ischemia-induced HIF-1{alpha} expression and ocular neovascularization, FASEB J., 24, 1759, 10.1096/fj.09-145664

Yuan, 2008, Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca(2+) signaling, prolyl hydroxylases, and mTOR, J. Cell. Physiol., 217, 674, 10.1002/jcp.21537

Yun, 2002, Inhibition of PPARgamma2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia, Dev. Cell, 2, 331, 10.1016/S1534-5807(02)00131-4

Zhang, 2008, Digoxin and other cardiac glycosides inhibit HIF-1 synthesis and block tumor growth, Proc. Natl. Acad. Sci. USA, 105, 19579, 10.1073/pnas.0809763105

Zhang, 2009, Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase, Cancer Cell, 16, 413, 10.1016/j.ccr.2009.09.029

Zhang, 2010, The asparaginyl hydroxylase factor inhibiting HIF-1α is an essential regulator of metabolism, Cell Metab., 11, 364, 10.1016/j.cmet.2010.03.001

Zhao, 2009, Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1, Science, 324, 261, 10.1126/science.1170944

Zhao, 2010, Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming, Oncogene, 29, 2962, 10.1038/onc.2010.67

Zhong, 2010, The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1, Cell, 140, 280, 10.1016/j.cell.2009.12.041

Zimmer, 2008, Small-molecule inhibitors of HIF-2a translation link its 5′UTR iron-responsive element to oxygen sensing, Mol. Cell, 32, 838, 10.1016/j.molcel.2008.12.004