Norman AW (2008) From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 88:491S–499S
Zhang R, Naughton DP (2010) Vitamin D in health and disease: current perspectives. Nutr J 9:65
Cappelletti P, Tozzoli R (2010) Laboratory and hypercalcemia. In: Lumachi F, Basso SMM (eds) Hypercalcemia pathophysiology and treatment. Bentham Science, Sharjah, pp 45–61
Rojas-Rivera J, De La Piedra C, Ramos A et al (2010) The expanding spectrum of biological actions of vitamin D. Nephrol Dial Transplant 25:2850–2865
Hewison M, Zehnder D, Chakraverty R et al (2004) Vitamin D and barrier function: a novel role for extra-renal 1a-hydroxylase. Mol Cell Endocrinol 215:31–38
Bises G, Kallay E, Weiland T et al (2004) 25-Hydroxyvitamin D3-1alpha-hydroxylase expression in normal and malignant human colon. J Histochem Cytochem 52:985–989
Adorini L, Penna G, Giarratana N et al (2004) Dendritic cells as key targets for immunomodulation by vitamin D receptor ligands. J Steroid Biochem Mol Biol 89–90:437–441
Zehnder D, Bland R, Chana RS et al (2002) Synthesis of 1, 25-dihydroxyvitamin D3 by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol 13:621–629
Eyles DW, Smith S, Kinobe R et al (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29:21–30
Segersten U, Holm PK, Bjorklund P et al (2005) 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1-hydroxylated vitamin D analogue. Breast Cancer Res 7:980–986
Townsend K, Evans KN, Campbell MJ et al (2005) Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment. J Steroid Biochem Mol Biol 97:103–119
Segersten U, Correa P, Hewison M et al (2002) 25-Hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands. J Clin Endocrinol Metab 87:2967–2972
Evans KN, Bulmer JN, Kilby MD et al (2004) Vitamin D and placental–decidual function. J Soc Gynecol Investig 11:263–271
Ma JF, Nonn L, Campbell MJ et al (2004) Mechanisms of decreased vitamin D 1alpha-hydroxylase activity in prostate cancer cells. Mol Cell Endocrinol 221:67–74
Bikle DD, Chang S, Crumrine D et al (2004) 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol 122:984–992
Griffin MD, Xing N, Kumar R (2003) Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 23:117–145
Norman AW, Mizwicki MT, Okamura WH (2003) Ligand structure–function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment). Recent Results Cancer Res 164:55–82
Holick MF (2006) Resurrection of vitamin D deficiency and rickets. J Clin Invest 116:2062–2072
DeLuca HF (2004) Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80:1689–1696
Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281
Cooke NE, Haddad JG (1989) Vitamin D binding protein (Gc-globulin). Endocr Rev 10:294–307
Dusso AS, Negrea L, Gunawardhana S et al (1991) On the mechanisms for the selective action of vitamin D analogs. Endocrinology 128:1687–1692
Takemoto F, Shinki T, Yokoyama K et al (2003) Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats. Kidney Int 64:414–420
Yamane T, Takeuchi K, Yamamoto Y et al (2002) Legumain from bovine kidney: its purification, molecular cloning, immunohistochemical localization and degradation of annexin II and vitamin D-binding protein. Biochim Biophys Acta 1596:108–120
Adams JS, Chen H, Chun RF et al (2003) Novel regulators of vitamin D action and metabolism: lessons learned at the Los Angeles zoo. J Cell Biochem 88:308–314
Nykjaer A, Dragun D, Walther D et al (1999) An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 96:507–515
Liu W, Yu WR, Carling T et al (1998) Regulation of gp330/megalin expression by vitamins A and D. Eur J Clin Investig 28:100–107
Brandi L (2008) 1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol—an active vitamin D analog. Clinical studies on prophylaxis and treatment of secondary hyperparathyroidism in uremic patients on chronic dialysis. Dan Med Bull 55:186–210
Brenza HL, Kimmel-Jehan C, Jehan F et al (1998) Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Proc Natl Acad Sci USA 95:1387–1391
Tsujikawa H, Kurotaki Y, Fujimori T et al (2003) Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17:2393–2403
Dong X, Lutz W, Schroeder TM et al (2005) Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter. Proc Natl Acad Sci USA 102:16007–16012
Adorini L, Penna G (2008) Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4:404–412
Norman AW, Mizwicki MT, Norman DPG (2004) Steroid hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 3:27–41
Pinette KV, Yee YK, Amegadzie BY et al (2003) Vitamin D receptor as a drug discovery target. Min Rev Med Chem 3:193–204
Brown AJ, Dusso A, Slatopolsky E (1999) Vitamin D. Am J Physiol Renal Physiol 277:F157–F175
Sutton ALM, MacDonald PN (2003) Vitamin D: more than a “bone-a-fide” hormone. Mol Endocrinol 17:777–791
Strugnell SA, Deluca HF (1997) The vitamin D receptor—structure and transcriptional activation. Proc Soc Exp Biol Med 215:223–228
Kliewer SA, Umesono K, Mangelsdorf DJ et al (1992) Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 355:446–449
Cheskis B, Freedman LP (1994) Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol Cell Biol 14:3329–3338
Dusso AS, Brown AJ (2009) Vitamin D: molecular biology and gene regulation. In: Singh AJ, Williams GH (eds) Textbook of nephro-endocrinology. Elsevier, San Diego, pp 69–93
Nagpal S, Na S, Rathnachalam R (2005) Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 26:662–687
Oñate SA, Tsai SY, Tsai MJ et al (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354–1357
Chen HW, Lin RJ, Schiltz RL et al (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569–580
Rachez C, Suldan Z, Ward J et al (1998) A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev 12:1787–1800
Chiba N, Suldan Z, Freedman LP et al (2000) Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme. J Biol Chem 275:10719–10722
Carvallo L, Henríquez B, Paredes R et al (2008) 1alpha, 25-Dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha, 25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. J Cell Physiol 214:740–749
Baudino TA, Kraichely DM, Jefcoat SC Jr et al (1998) Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. J Biol Chem 273:16434–16441
Zhang C, Dowd DR, Staal A et al (2003) Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem 278:35325–35336
Dunlop TW, Väisänen S, Frank C et al (2004) The genes of the coactivator TIF2 and the corepressor SMRT are primary 1alpha, 25(OH)2D3 targets. J Steroid Biochem Mol Biol 89–90:257–260
Adorini L, Penna G (2009) Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol 70:345–352
Cutolo M (2009) Vitamin D and autoimmune rheumatic diseases. Rheumatology 48:210–212
van Etten E, Mathieu C (2005) Immunoregulation by 1, 25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 97:93–101
Liu PT, Stenger S, Li H et al (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770–1773
Wang TT, Nestel FP, Bourdeau V et al (2004) Cutting edge: 1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173:2909–2912
Schauber J, Dorschner RA, Coda AB et al (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117:803–811
Sigmundsdottir H, Pan J, Debes GF et al (2007) DCs metabolize sunlight-induced vitamin D3 to ‘program’ T cell attraction to the epidermal chemokine CCL27. Nat Immunol 8:285–293
Chen S, Sims GP, Chen XX et al (2007) Modulatory effects of 1, 25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 179:1634–1647
Mattner F, Smiroldo S, Galbiati F et al (2000) Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1, 25-dihydroxyvitamin D(3). Eur J Immunol 30:498–508
Cippitelli M, Santoni A (1998) Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Eur J Immunol 28:3017–3030
Penna G, Amuchastegui S, Cossetti C et al (2006) Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J Immunol 177:8504–8511
Penna G, Amuchastegui S, Giarratana N et al (2007) 1, 25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J Immunol 178:145–153
Adorini L, Giarratana N, Penna G (2004) Pharmacological induction of tolerogenic dendritic cells and regulatory T cells. Semin Immunol 16:127–134
Penna G, Adorini L (2000) 1 alpha, 25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164:2405–2411
Penna G, Roncari A, Amuchastegui S et al (2005) Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4 + Foxp3+ regulatory T cells by 1, 25-dihydroxyvitamin D3. Blood 106:3490–3497
Hewison M, Freeman L, Hughes SV et al (2003) Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol 170:5382–5390
Adorini L (2005) Intervention in autoimmunity: the potential of vitamin D receptor agonists. Cell Immunol 233:115–124
Griffin MD, Dong X, Kumar R (2007) Vitamin D receptor-mediated suppression of RelB in antigen presenting cells: a paradigm for ligand-augmented negative transcriptional regulation. Arch Biochem Biophys 460:218–226
Liu YJ (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 23:275–306
Lemire JM, Archer DC, Beck L et al (1995) Immunosuppressive actions of 1, 25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 125:1704S–1708S
D’Ambrosio D, Cippitelli M, Cocciolo MG et al (1998) Inhibition of IL-12 production by 1, 25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 101:252–262
Boonstra A, Barrat FJ, Crain C et al (2001) 1alpha, 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 167:4974–4980
Mahon BD, Wittke A, Weaver V et al (2003) The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 89:922–932
Steinman L (2007) A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 13:139–145
Gregori S, Giarratana N, Smiroldo S et al (2002) A 1alpha, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 51:1367–1374
Gregori S, Casorati M, Amuchastegui S et al (2001) Regulatory T cells induced by 1 alpha, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167:1945–1953
Curiel TJ, Coukos G, Zou L et al (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10:942–949
Adams JS, Hewison M (2010) Update in vitamin D. J Clin Endocrinol Metab 95:471–478
Antico A (2008) Autoimmune gastritis. It J Lab Med 4:125–133
De Block CE, De Leeuw IH, Van Gaal LF (2008) Autoimmune gastritis in type 1 diabetes: a clinically oriented review. J Clin Endocrinol Metab 93:363–371
Holick MF (2006) High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81:353–373
Kairisto V, Poola A (1995) Software for illustrative presentation of basic clinical characteristics of laboratory tests—GraphROC for Windows. Scand J Clin Lab Invest 222:43–60
Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080–1086