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Sự kích hoạt của nhân không gian ngoài trong vùng dưới đồi góp phần vào sự kích thích thần kinh - nội tiết ở chuột bị suy tim
Tóm tắt
Suy tim (HF) là một bệnh tim mạch nghiêm trọng và đặc trưng bởi hoạt động giao cảm được tăng cường. Trong bài báo này, chúng tôi xem xét các nghiên cứu hạn chế về chủ đề này, đặc biệt nhấn mạnh vào vai trò của nhân không gian ngoài (PVN) trong sự kích thích thần kinh - nội tiết ở HF. PVN là một nhân thần kinh nội tiết quan trọng và là một đầu ra tự chủ chính, được xem là vị trí trung tâm quan trọng cho việc tích hợp hoạt động của dây thần kinh giao cảm. Các bằng chứng tích lũy cho thấy có nhiều quá trình thần kinh - nội tiết liên quan đến sinh lý bệnh của HF, chẳng hạn như hệ thống renin-angiotensin (RAS), các cytokine proinflammatory (PICs), các chất dẫn truyền thần kinh và các gốc tự do oxy (ROS). Các nghiên cứu gần đây về điều hòa thần kinh - nội tiết chỉ ra rằng thụ thể angiotensin II loại 1 (AT1-R) là sản phẩm quan trọng do yếu tố nhân tế bào vị diện-kappa B (NF-κB) trung gian, được tăng cường cùng với các PICs và angiotensin II (ANG II) trong PVN của chuột HF. Những phát hiện này cho thấy NF-κB làm trung gian cho sự giao thoa giữa RAS và PICs trong PVN ở HF. Các nghiên cứu tiếp theo chỉ ra rằng sự tương tác giữa AT1-R và NF-κB trong PVN góp phần vào stress oxy hóa và sự kích thích giao cảm bằng cách điều chỉnh các chất dẫn truyền thần kinh trong suy tim, và superoxide kích hoạt NF-κB trong PVN và góp phần vào sự kích thích thần kinh - nội tiết. Tóm lại, sự kích thích thần kinh - nội tiết trong HF dựa trên sự tương tác của RAS, PICs, ROS, NF-κB và các chất dẫn truyền thần kinh trong PVN; và NF-κB được kích hoạt trong PVN điều chỉnh các chất dẫn truyền thần kinh và góp phần vào sự kích thích giao cảm ở chuột bị suy tim.
Từ khóa
#suy tim #hoạt động giao cảm #nhân không gian ngoài #phản ứng thần kinh - nội tiết #stress oxy hóaTài liệu tham khảo
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