Hypospadias: a transgenerational effect of diethylstilbestrol?

Human Reproduction - Tập 21 Số 3 - Trang 666-669 - 2006
Marijn M. Brouwers1, Wouter F.J. Feitz, L.A.J. Roelofs, Lambertus A. Kiemeney, R.P.E. de Gier, Nel Roeleveld
1Department of Epidemiology and Biostatistics (133), Radboud University Nijmegen Medical Centre, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. [email protected]

Tóm tắt

Từ khóa


Tài liệu tham khảo

Blatt J , Van Le L, Weiner T and Sailer S (2003) Ovarian carcinoma in an adolescent with transgenerational exposure to diethylstilbestrol. J Pediatr Hematol Oncol25,635–636.

Fisch H , Golden RJ, Libersen GL, Hyun GS, Madsen P, New MI and Hensle TW (2001) Maternal age as a risk factor for hypospadias. J Urol165,934–936.

Fredell L , Iselius L, Collins A, Hansson E, Holmner S, Lundquist L, Lackgren G, Pedersen J, Stenberg A, Westbacke G et al (2002) Complex segregation analysis of hypospadias. Hum Genet111,231–234.

Fredell L , Kockum I, Hansson E, Holmner S, Lundquist L, Lackgren G, Pedersen J, Stenberg A, Westbacke G and Nordenskjold A (2002) Heredity of hypospadias and the significance of low birth weight. J Urol167,1423–1427.

Giusti RM , Iwamoto K and Hatch EE (1995) Diethylstilbestrol revisited: a review of the long-term health effects. Ann Intern Med122,778–788.

Hernandez-Diaz S (2002) Iatrogenic legacy from diethylstilbestrol exposure. Lancet359,1081–1082.

Hussain N , Chaghtai A, Herndon CD, Herson VC, Rosenkrantz TS and McKenna PH (2002) Hypospadias and early gestation growth restriction in infants. Pediatrics109,473–478.

Klip H , Verloop J, van Gool JD, Koster ME, Burger CW and van Leeuwen FE (2002) Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study. Lancet359,1102–1107.

Manson JM and Carr MC (2003) Molecular epidemiology of hypospadias: review of genetic and environmental risk factors. Birth Defects Res A, Clini Mol Teratol67,825–836.

Newbold RR , Hanson RB, Jefferson WN, Bullock BC, Haseman J and McLachlan JA (1998) Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis19,1655–1663.

Newbold RR , Hanson RB, Jefferson WN, Bullock BC, Haseman J and McLachlan JA (2000) Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis21,1355–1363.

North K and Golding J (2000) A maternal vegetarian diet in pregnancy is associated with hypospadias The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Br J Urol Int85,107–113.

Palmer JR , Wise LA, Robboy SJ, Titus-Ernstoff L, Moller KL, Herbst AL, Troisi R and Hoover RN (2005) Hypospadias in sons of women exposed to diethylstilbestrol in utero. Epidemiology16,583–586.

Pierik FH , Burdorf A, Nijman JM, de Muinck Keizer-Schrama SM, Juttmann RE and Weber RF (2002) A high hypospadias rate in The Netherlands. Hum Reprod17,1112–1115.

Pierik FH , Burdorf A, Deddens JA, Juttmann RE and Weber RF (2004) Maternal and paternal risk factors for cryptorchidism and hypospadias: a case–control study in newborn boys. Environ Health Perspect112, 1570–1576.

Pons JC , Papiernik E, Billon A, Hessabi M and Duyne M (2005) Hypospadias in sons of women exposed tot diethylstilbestrol in utero. Prenat Diagn25,418–419.

Silver RI , Rodriguez R, Chang TS and Gearhart JP (1999) In vitro fertilization is associated with an increased risk of hypospadias. J Urol161,1954–1957.

Sorber M , Feitz WF and de Vries JD (1997) Short- and mid-term outcome of different types of one-stage hypospadias corrections. Eur Urol32,475–479.

Weidner IS , Moller H, Jensen TK and Skakkebaek NE (1999) Risk factors for cryptorchidism and hypospadias. J Urol161,1606–1609.

Wennerholm UB , Bergh C, Hamberger L, Lundin K, Nilsson L, Wikland M and Kallen B (2000) Incidence of congenital malformations in children born after ICSI. Hum Reprod15,944–948.