Hypoparathyroidism after the treatment of laryngopharyngeal carcinoma
Tóm tắt
Thirty patients with squamous cell carcinoma of the laryngopharynx were treated with surgery (total laryngectomy and hemithyroidectomy) and radiotherapy. Group 1 (n = 7) patients had surgery only; Group 2 (n = 7) had radiotherapy followed by salvage surgery while Group 3 (n = 16) had surgery followed by radiotherapy.
Parathyroid hormone and calcium levels were measured pre- and post-operatively and pdstradiotherapy. In Group 1 no patients were hypoparathyroid. In Group 2, 29 per cent of patients preoperatively and 57 per cent post-operatively, were hypoparathyroid. In Group 3, no patients were hypoparathyroid pre-operatively, while 25 per cent were hypoparathyroid post-operatively and postradiotherapy. Parathyroid honnone and calcium levels were averaged and compared within and between each group. There was no significant difference within each group, when comparing levels postoperatively and post-radiotherapy from those of pre-operatively. There was no significant difference in levels between each of Groups 1, 2 or 3 (
Từ khóa
Tài liệu tham khảo
Isaacson, 1977, Hypoparathyroidism secondary to surgery for carcinoma of the pharynx and larynx, Transatlantic American Academy of Ophthalmology and Otolaryngology, 84, 584
Isaacson, 1980, Hypocalcaemia in surgery for carcinoma of the pharynx and larynx, Otolaryngologic Clinics of North America, 13, 181, 10.1016/S0030-6665(20)32405-1
Ledger, 1994, Hypocalcaemia and hypoparathyroidism, Current Therapy in Endocrinology and Metabolism, 5, 508
Bellamy, 1995, Unrecognized hypocalcaemia 36 years after thyroidectomy, Journal of the Royal Society of Medicine, 88, 690, 10.1177/014107689508801210
Buchanan, 1975, Hypoparathyroidism following pharyngolaryngooesophagectomy, Clinical Oncology, 1, 89
Gregor, 1997, Operative Otorhinolaryngology, 365
Laehman, 1994, A post-thryoidectomy convulsion: an unusual presentation of chronic hypoparathyroidism, West Virginia Medical Journal, 90, 420
Sasaki, 1993, Otolaryngology – Head and Neck Surgery, 1925
Stell, 1993, Stell and Maran's Head and Neck Surgery, 153
Van Middlesworth, 1993, Otolaryngology – Head and Neck Surgery, 2408