Hypogymnia physodes – A lichen with interesting medicinal potential and ecological properties

Ari, 2014, Genotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells, Environ. Toxicol., 29, 804, 10.1002/tox.21809 Bennett, 1996, Element concentrations in the lichen Hypogymnia physodes (L.) Nyl. after 3 years of transplanting along Lake Michigan, Environ. Exp. Bot., 36, 255, 10.1016/0098-8472(96)01022-2 Białońska, 2005, Chemistry of the lichen Hypogymnia physodes transplanted to an industrial region, J. Chem. Ecol., 31, 2975, 10.1007/s10886-005-8408-x Bystrek, 1997 Bustinza, 1952, Antibacterial substances from lichens, Econ. Bot., 6, 402, 10.1007/BF02984888 Cragg, 2009, Impact of natural products on developing new anti-cancer agents, Chem. Rev., 109, 3012, 10.1021/cr900019j Cansaran-Duman, 2011, Study on accumulation ability of two lichen species Hypogymnia physodes and Usnea hirta at iron-steel factory site, Turkey, J. Environ. Biol., 32, 839 Caviglia, 2001, Oxidative stress and usnic acid content in Parmelia caperata and Parmelia soredians (lichens), Il Farm., 56, 379, 10.1016/S0014-827X(01)01090-4 Culberson, 1979 Deduke, 2012, Effect of environmental change on secondary metabolite production in lichen–forming fungi, 197 Emsen, 2015, In vitro antitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells, Pharm. Biol., 24, 1 Emsen, 2016, Evaluation of antioxidant and cytotoxic effects of olivetoric and physodic acid in cultured human amnion fibroblasts, Hum. Exp. Toxicol. Adv. Elix, 2008, Biochemistry and secondary metabolites, 105 Fałtynowicz, 2012 Gollapudi, 1994, Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa, J. Nat. Prod., 57, 934, 10.1021/np50109a009 Halama, 2004, Antifungal activity of lichen extracts and lichenic acids, BioControl, 49, 95, 10.1023/B:BICO.0000009378.31023.ba Hauck, 2008, Metal homeostasis in Hypogymnia physodes is controlled by lichen substances, Environ. Pollut., 153, 304, 10.1016/j.envpol.2007.08.023 Hauck, 2013, Lichen substance concentrations in the lichen Hypogymnia physodes are correlated with heavy metal concentrations in the substratum, Environ. Exper. Bot., 85, 58, 10.1016/j.envexpbot.2012.08.011 Hauck, 2007, Lichen substances affect metal adsorption in Hypogymnia physodes, J. Chem. Ecol., 33, 219, 10.1007/s10886-006-9225-6 Huneck, 1999, The significance of lichens and their metabolites, Naturwissenschaften, 86, 559, 10.1007/s001140050676 Huneck, 1996 Ingólfsdóttir, 2002, Usnic acid, Phytochemistry, 61, 729, 10.1016/S0031-9422(02)00383-7 Kosanić, 2011, Antioxidant properties of some lichen species, J. Food Sci. Technol., 48, 584, 10.1007/s13197-010-0174-2 Kosanić, 2013, Investigation of selected serbian lichens for antioxidant, antimicrobial and anticancer properties, JAPS, 23, 1628 Latkowska, 2015, Secondary metabolites of the lichens Hypogymnia physodes (L.) Nyl. And their presence in spruce (Picea abies (L.) H. Karst.) bark, Phytochemistry, 118, 116, 10.1016/j.phytochem.2015.08.016 Lawrey, 1999, Destruction of lichen chemical defenses by a fungal pathogen, Am. J. Bot., 86, 184, 10.2307/2656935 Legaz, 2011, Bioproduction of depsidones for pharmaceutical purposes, 487 Lippo, 1995, The use of moss, lichen and pine bark in the nationwide monitoring of atmospheric heavy metal deposition in Finaland, Water Air Soil Pollut., 85, 2241, 10.1007/BF01186167 Matwiejuk, 2008, Porosty i ich właściwości lecznicze, Kosmos. Probl. Nauk Biol., 57, 85 McDonald, 2013, Twenty-five cultures of lichenizing fungi available for experimental studies on symbiotic systems, Symbiosis, 59, 165, 10.1007/s13199-013-0228-0 Mitrović, 2011, Antioxidant, antimicrobial and antiproliferative activities of five lichen species, Int. J. Mol. Sci., 12, 5428, 10.3390/ijms12085428 Mitrovic, 2015, Contribution to the knowledge of the chemical composition and biological activity of the lichens Cladonia foliacea Huds. (Wild.) and Hypogymnia physodes (L.), Oxid. Commun, 38, 2016 Molnár, 2010, Current results on biological activities of lichen secondary metabolites: a review, Z. Naturforsch. C, 65, 157, 10.1515/znc-2010-3-401 Molnár, 2011, Depsides and depsidones in populations of the lichen Hypogymnia physodes and its genetic diversity, Ann. Bot. Fenn., 48, 473, 10.5735/085.048.0605 Müller, 2001, Pharmaceutically relevant metabolites from lichens, Appl. Microbiol. Biotechnol., 56, 9, 10.1007/s002530100684 Neamati, 1997, Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching, J. Med. Chem., 40, 942, 10.1021/jm960759e Osawa, 1991, Inhibitory effect of lichen constituents on mutagenicity induced by heterocyclic amines, Environ. Mol. Mutagen, 18, 35, 10.1002/em.2850180107 Pavlović, 2013, Effect of four lichen acids isolated from Hypogymnia physodes on viability of rat thymocytes, Food Chem. Toxicol., 51, 160, 10.1016/j.fct.2012.04.043 Pham-Huy, 2008, Free radicals, antioxidants in disease and health, Int. J. Biomed. Sci., 4, 89, 10.59566/IJBS.2008.4089 Poličnik, 2004, Monitoring of short-term heavy metal deposition by accumulation in epiphytic lichens (Hypogymnia physodes (L.) Nyl.), J. Atmos. Chem., 49, 223, 10.1007/s10874-004-1227-6 Pöykkö, 2010, Host use of a specialist lichen–feeder: dealing with lichen secondary metabolites, Oecologia, 164, 423, 10.1007/s00442-010-1682-5 Pöykkö, 2005, Removal of lichen secondary metabolites affects food choice and survival of lichenivorous moth larvae, Ecology, 86, 2623, 10.1890/04-1632 Proksa, 1994, Metabolites of Pseudevernia furfuracea (L.) Zopf. and their inhibition potential of proteolytic enzymes, Pharmazie, 49, 282 Purvis, 1992 Ranković, 2015, Lichens as a potential source of bioactive secondary metabolites, 1 Ranković, 2008, The antimicrobial activity of substances derived from the lichens Physcia aipola, Umbilicaria polyphylla, Parmelia caperata and Hypogymnia physodes, World J. Microbiol. Biotechnol., 24, 1239, 10.1007/s11274-007-9580-7 Ranković, 2014, Chemical composition of Hypogymnia physodes lichen and biological activities of some its major metabolites, Med. Chem. Res., 23, 408, 10.1007/s00044-013-0644-y Shibamoto, 1984, Mutagenicity of lichen constituents, Environ. Mutagen., 6, 757, 10.1002/em.2860060512 Shukla, 2010, Lichens as a potential natural source of bioactive compounds: a review, Phytochem. Rev., 9, 303, 10.1007/s11101-010-9189-6 Solhaug, 2009, Possible functional roles of cortical depsides and medullary depsidones in the foliose lichen Hypogymnia physodes, Flora, 204, 40, 10.1016/j.flora.2007.12.002 Song, 2014, Plant-derived natural products as leads to anti-cancer drugs, J. Med. Plant Herb. Ther. Res, 2, 6 Stojanović, 2011, Volatile constituents of selected Parmeliaceae lichens, J. Serb. Chem. Soc., 76, 987, 10.2298/JSC101004087S Stojanović, 2010, Reducing power and radical scavenging activity of four Parmeliaceae species, Cent. Eur. J. Biol., 5, 808 Studzińska-Sroka, 2016, Cytotoxic activity of physodic acid and acetone extract from Hypogymnia physodes against breast cancer cell lines, Pharm. Biol., 6, 1 Thune, 1980, Photosensitivity and allergy to aromatic lichen acids, compositae oleoresins and other plant substances, Contact Derm., 6, 64, 10.1111/j.1600-0536.1980.tb03907.x Tobolewski, 1972 Türk, 2006, Antimicrobial activity of extracts of chemical races of the lichen Pseudevernia furfuracea and their physodic acid, chloroatranorin, atranorin and olivetoric acid constituents, Z. Naturfosch. [C], 61, 499, 10.1515/znc-2006-7-806 Türkez, 2012, Effects of lichenic extracts (Hypogymnia physodes, Ramalina polymorpha and Usnea florida) on human blood cells: cytogenetic and biochemical study, Iran. J. Pharm. Res., 11, 889 Wirth, 1995 Yilmaz, 2005, The antimicrobial activity of extracts of the lichen Hypogymnia tubulosa and its 3-hydroxyphysodic acid constituent, Z. Naturforsch. C, 60, 35, 10.1515/znc-2005-1-207