Hypoalgesic responses resulting from paired or separate exposures to naloxone and a heat Stressor: Evidence from the tail-flick radiant heat test
Tóm tắt
Rats given unpaired exposures to naloxone and the heated floor of a hot-plate apparatus acquired hypoalgesia, as evidenced by long latencies to paw-lick and tail-flick. Acquisition of hypoalgesia was found to be potentiated when preexposure to the heat Stressor was paired with naloxone. The hypoalgesic responses detected with the tail-flick radiant heat test were reversed by naloxone and were not acquired by morphine-experienced rats, suggesting mediation by endogenous opioid mechanisms. The hypoalgesic responses can be modulated by cholecystokinin because the long tail-flick latencies were abolished by CCK-8. However, there was no evidence for a potentiation of these hypoalgesic responses by proglumide. There was also no evidence that naloxone had interacted with the heat stimulus of the tail-flick test employed to induce hypoalgesia. The present results are discussed in terms of their implications for using the tail-flick and hot-plate tests in studies investigating stress-induced hypoalgesia and morphine hypoalgesic tolerance.
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