Hypervalent Iodine(III) Sulfonate Mediated Synthesis of Quinoxalines in Liquid PEG‐400

Journal of the Chinese Chemical Society - Tập 56 Số 4 - Trang 683-687 - 2009
Pei‐Ying Lin1, Rei‐Sheu Hou2, Huey‐Min Wang2, Iou‐Jiun Kang3, Ling‐Ching Chen1
1Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
2Chung Hwa University of Medical Technology, Tainan 717, Taiwan, R.O.C.
3Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, R.O.C.

Tóm tắt

AbstractPEG‐400[poly(ethylene glycol‐400)] is used as a “green” recyclable solvent in the one‐pot synthesis of quinoxalines by reaction with aryl ketones, hypervalent Iodine(III) Sulfonate, and o‐phenylenediamines. Significant rate enhancements and improved yields have been observed.

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